Identification of Quinazolinone Analogs Targeting CDK5 Kinase Activity and Glioblastoma Cell Proliferation

Autor: Marion Peyressatre, Dominique Patomo Arama, Arthur Laure, Juan A. González-Vera, Morgan Pellerano, Nicolas Masurier, Vincent Lisowski, May C. Morris

Publikováno v: Frontiers in Chemistry, Vol 8 (2020)

CDK5/p25 kinase plays a major role in neuronal functions, and is hyperactivated in several human cancers including glioblastoma and neurodegenerative pathologies such as Alzheimer's and Parkinson's. CDK5 therefore constitutes an attractive pharmacolo

Externí odkaz: https://doaj.org/article/914420937d754a1d94fae9a9b77bb833

Author response for 'CDK6 is activated by the atypical cyclin I to promote E2F ‐mediated gene expression and cancer cell proliferation'

Autor: null Eva Quandt, null Núria Masip, null Sara Hernández‐Ortega, null Abril Sánchez‐Botet, null Laura Gasa, null Ainhoa Fernández‐Elorduy, null Sara Plutta, null Joan Marc Martínez‐Láinez, null Samuel Bru, null Pau M. Munoz‐Torres, null Martin Floor, null Jordi Villà‐Freixa, null May C. Morris, null August Vidal, null Alberto Villanueva, null Josep Clotet, null Mariana P.C. Ribeiro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::081541c2905d50af9b472ff7e0059db7
https://doi.org/10.1002/1878-0261.13438/v2/response1

Fluorescent Peptide Biosensor for Probing CDK6 Kinase Activity in Lung Cancer Cell Extracts

Autor: Mathieu Galibert, Christophe Blanquart, Morgan Pellerano, Karine Puget, Magali Jullian, Sebastien Diot, Jessica Soamalala, May C. Morris

Publikováno v: ChemBioChem
ChemBioChem, Wiley-VCH Verlag, 2020, Online ahead of print. ⟨10.1002/cbic.202000677⟩
ChemBioChem, 2020, Online ahead of print. ⟨10.1002/cbic.202000677⟩

International audience; CDK6 kinase regulates cell cycle progression in G1, together with CDK4, but has cell-, tissue- and developmentally-distinct functions associated with transcription, angiogenesis and metabolism. Although CDK6 constitutes an att

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0af4ae050efbed28bb6babbeb9dbd686
https://doi.org/10.1002/cbic.202000677

When mentoring matters: a French mentoring program for women in science

Autor: Julie Batut, Marina Kvaskoff, May C. Morris

Publikováno v: Nature Biotechnology
Nature Biotechnology, Nature Publishing Group, 2021, 39 (6), pp.776-779. ⟨10.1038/s41587-021-00951-2⟩
Nature Biotechnology, 2021, 39 (6), pp.776-779. ⟨10.1038/s41587-021-00951-2⟩

International audience; An innovative program addresses the need for support, encouragement and guidance on the part of women scientists in the early years of their career, during their PhD.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d58432303381ee3470dcf7eb34a5089
https://hal.archives-ouvertes.fr/hal-03413801

Nanobiosensor Reports on CDK1 Kinase Activity in Tumor Xenografts in Mice

Autor: Alberto Bianco, May C. Morris, Cécilia Ménard-Moyon, Véronique Josserand, Sebastien Diot, Bhimareddy Dinesh, Morgan Pellerano, Mélanie Guidetti, Julien Vollaire, Carmen Tîlmaciu

Probing the dynamics and quantifying the activities of intracellular protein kinases that coordinate cell growth and division and constitute biomarkers and pharmacological targets in hyperproliferative and pathological disorders remain a challenging

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::520e56bdbb8820502802cad0ca55ed1d
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