Repurposed drugs block toxin-driven platelet clearance by the hepatic Ashwell-Morell receptor to clear Staphylococcus aureus bacteremia

Autor: Yohei Kohno, Josh Sun, George Sakoulas, Victor Nizet, Bernice Aguilar, Ingrid Cornax, Jamey D. Marth, May M. T. Kyaw, Nina M. Haste, Taisuke Kanaji, Yosuke Morodomi, Joshua Olson, Satoshi Uchiyama, Sachiko Kanaji, Warren E. Rose, Nao Ando

Publikováno v: Science Translational Medicine. 13

Staphylococcus aureus (SA) bloodstream infections cause high morbidity and mortality (20 to 30%) despite modern supportive care. In a human bacteremia cohort, we found that development of thrombocytopenia was correlated to increased mortality and inc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c289416f8910de8714cb7f5bc3e0b2b7
https://doi.org/10.1126/scitranslmed.abd6737

Repurposed drugs block toxin-driven platelet clearance by the hepatic Ashwell-Morell receptor to clear

Autor: Josh, Sun, Satoshi, Uchiyama, Joshua, Olson, Yosuke, Morodomi, Ingrid, Cornax, Nao, Ando, Yohei, Kohno, May M T, Kyaw, Bernice, Aguilar, Nina M, Haste, Sachiko, Kanaji, Taisuke, Kanaji, Warren E, Rose, George, Sakoulas, Jamey D, Marth, Victor, Nizet

Publikováno v: Sci Transl Med

Staphylococcus aureus (SA) bloodstream infections cause high morbidity and mortality (20–30%) despite modern supportive care. In a human bacteremia cohort, development of thrombocytopenia was correlated to increased mortality and increased α-toxin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e8783ceaf003ec6914ee7a151d6a7b0e
https://pubmed.ncbi.nlm.nih.gov/33762439

Parameter estimates for trends and patterns of excess mortality among persons on ART in high-income european settings

Autor: TRICKEY, A., VAN SIGHEM, A., STOVER, J., ABGRALL, S., GRABAR, S., BONNET, Fabrice, BERENGUER, J., WYEN, C., CASABONA, J., D'ARMINIO MONFORTE, A., CAVASSINI, M., DEL AMO, J., ZANGERLE, R., GILL, M. J., OBEL, N., STERNE, J. A. C., MAY, M. T.

Publikováno v: AIDS. Official journal of the international AIDS Society
AIDS. Official journal of the international AIDS Society, Wolters Kluwer Health, 2019, 33 (Suppl 3), pp.S271-S281

International audience; INTRODUCTION: HIV cohort data from high-income European countries were compared to the UNAIDS Spectrum modelling parameters for these same countries to validate mortality rates and excess mortality estimates for people living

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::c1b95f9bddb22b7debf3da3a119d2836
https://hal.archives-ouvertes.fr/hal-03162415/document

Long-term trends in CD4 cell counts, CD8 cell counts, and the CD4: CD8 ratio: ART Cohort Collaboration (ART-CC) Study

Autor: HUGHES, R. A., MAY, M. T., TILLING, K., TAYLOR, N., WITTKOP, Linda, REISS, P., GILL, J., SCHOMMERS, P., COSTAGLIOLA, D., GUEST, J. L., LIMA, V. D., MONFORTE, A. D., SMITH, C., CAVASSINI, M., SAAG, M., STERLING, T. R., STERNE, J. A. C.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______9631::cb716e3c4b7d482806a99bd3d8c04dfc
http://hdl.handle.net/20.500.12278/14049

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.