Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Maxwell R. Mumbach"'
Autor:
Jan-Renier Moonen, James Chappell, Minyi Shi, Tsutomu Shinohara, Dan Li, Maxwell R. Mumbach, Fan Zhang, Ramesh V. Nair, Joseph Nasser, Daniel H. Mai, Shalina Taylor, Lingli Wang, Ross J. Metzger, Howard Y. Chang, Jesse M. Engreitz, Michael P. Snyder, Marlene Rabinovitch
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Here the authors studied pulmonary arterial endothelial cells (PAEC) under laminar shear stress and show that this physiologic condition markedly changes chromatin accessibility at regulatory regions, when compared to cells grown in a static state. T
Externí odkaz:
https://doaj.org/article/dd0de669b721470b8265ca8d188386af
Autor:
Elena López-Isac, Marialbert Acosta-Herrera, Martin Kerick, Shervin Assassi, Ansuman T. Satpathy, Jeffrey Granja, Maxwell R. Mumbach, Lorenzo Beretta, Carmen P. Simeón, Patricia Carreira, Norberto Ortego-Centeno, Ivan Castellvi, Lara Bossini-Castillo, F. David Carmona, Gisela Orozco, Nicolas Hunzelmann, Jörg H. W. Distler, Andre Franke, Claudio Lunardi, Gianluca Moroncini, Armando Gabrielli, Jeska de Vries-Bouwstra, Cisca Wijmenga, Bobby P. C. Koeleman, Annika Nordin, Leonid Padyukov, Anna-Maria Hoffmann-Vold, Benedicte Lie, European Scleroderma Group, Susanna Proudman, Wendy Stevens, Mandana Nikpour, Australian Scleroderma Interest Group (ASIG), Timothy Vyse, Ariane L. Herrick, Jane Worthington, Christopher P. Denton, Yannick Allanore, Matthew A. Brown, Timothy R. D. J. Radstake, Carmen Fonseca, Howard Y. Chang, Maureen D. Mayes, Javier Martin
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Systemic sclerosis (SSc) is a heterogeneous chronic autoimmune disease that affects the connective tissue. Here, López-Isac et al. identify 13 new risk loci for SSc as well as loci specific for limited cutaneous and diffuse SSc and, defining credibl
Externí odkaz:
https://doaj.org/article/2c83b5b19dd94142a96da7824aa29e78
Autor:
Schraga Schwartz, Maxwell R. Mumbach, Marko Jovanovic, Tim Wang, Karolina Maciag, G. Guy Bushkin, Philipp Mertins, Dmitry Ter-Ovanesyan, Naomi Habib, Davide Cacchiarelli, Neville E. Sanjana, Elizaveta Freinkman, Michael E. Pacold, Rahul Satija, Tarjei S. Mikkelsen, Nir Hacohen, Feng Zhang, Steven A. Carr, Eric S. Lander, Aviv Regev
Publikováno v:
Cell Reports, Vol 8, Iss 1, Pp 284-296 (2014)
N6-methyladenosine (m6A) is a common modification of mRNA with potential roles in fine-tuning the RNA life cycle. Here, we identify a dense network of proteins interacting with METTL3, a component of the methyltransferase complex, and show that three
Externí odkaz:
https://doaj.org/article/9efb69ac280f4b9e8e40a095f2951637
Autor:
M. Ryan Corces, S. Tansu Bagdatli, Stephen B. Montgomery, Maxwell R. Mumbach, Anna Shcherbina, Bryan H. Louie, Kathleen S. Montine, Soumya Kundu, Shadi Shams, Michael J. Gloudemans, Howard Y. Chang, Anshul Kundaje, Tiffany Eulalio, Jeffrey M. Granja, Laure Fresard, Boxiang Liu, William J. Greenleaf, Thomas J. Montine
Publikováno v:
Nature genetics
Genome-wide association studies (GWAS) of neurological diseases have identified thousands of variants associated with disease phenotypes. However, the majority of these variants do not alter coding sequences, making it difficult to assign their funct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf0965d48f1f996f90a7db28fba25b78
https://doi.org/10.1038/s41588-020-00721-x
https://doi.org/10.1038/s41588-020-00721-x
Autor:
Rabab Nasrallah, Dafni A. Glinos, Adrian Liston, Lindsey Placek, Howard Y. Chang, Enrico Lugli, Sarah K. Whiteside, Teresa Lozano, Toshitsugu Fujita, Lina Kozhaya, Francis M. Grant, Rahul Roychoudhuri, Mikail Dogan, Maxwell R. Mumbach, Jie Yang, Charlotte J. Imianowski, Suman Mitra, Gosia Trynka, Derya Unutmaz, Hodaka Fujii, Panagiota Vardaka, Paula Kuo, Lara Bossini-Castillo, Firas Sadiyah, Carly E. Whyte, Adeline Cozzani, Simon Andrews
Publikováno v:
Nature. 583:447-452
Genetic variations underlying susceptibility to complex autoimmune and allergic diseases are concentrated within noncoding regulatory elements termed enhancers1. The functions of a large majority of disease-associated enhancers are unknown, in part o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::985aaa5ed38002ce4d7c1c653f380fea
https://doi.org/10.1038/s41586-020-2296-7
https://doi.org/10.1038/s41586-020-2296-7
Autor:
Karen L. Smith, Jörn Coers, Alexis M. Schneider, Raktima Raychowdhury, Schraga Schwartz, Karolina Maciag, Nir Hacohen, Maxwell R. Mumbach
Publikováno v:
Journal of leukocyte biology. 112(2)
Macrophages use an array of innate immune sensors to detect intracellular pathogens and to tailor effective antimicrobial responses. In addition, extrinsic activation with the cytokine IFN-γ is often required as well to tip the scales of the host-pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3ae0a03a884935e3dbf812b511f4f85
https://pubmed.ncbi.nlm.nih.gov/34826345
https://pubmed.ncbi.nlm.nih.gov/34826345
Autor:
Mark Y. Jeng, Ansuman T. Satpathy, Howard Y. Chang, Maxwell R. Mumbach, Anne Lynn S. Chang, Jeffrey M. Granja
Publikováno v:
Journal of Investigative Dermatology. 139:605-614
The vast majority of polymorphisms for human dermatologic diseases fall in noncoding DNA regions, leading to difficulty interpreting their functional significance. Recent work using chromosome conformation capture technology in combination with chrom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d10720614ea9624894c9e34c4c3d3c2
https://doi.org/10.1016/j.jid.2018.09.011
https://doi.org/10.1016/j.jid.2018.09.011
Autor:
Aditi Limaye, Cameron O. Schmitz, Howard Y. Chang, Maxwell R. Mumbach, Ryan A. Flynn, Jin Wei, Yuki Yasumoto, Julia A. Belk, Yanyan Qi, Jan E. Carette, Kevin R. Parker, Tamas L. Horvath, Mia Madel Alfajaro, Carolyn R. Bertozzi, Craig B. Wilen, Ansuman T. Satpathy
Publikováno v:
Cell
bioRxiv
article-version (status) pre
article-version (number) 1
bioRxiv
article-version (status) pre
article-version (number) 1
SARS-CoV-2 is the cause of a pandemic with growing global mortality. Using comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS), we identified 309 host proteins that bind the SARS-CoV-2 RNA during active infection. Int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7efe2ca542dcf7c25a14cbd2d3a8f8c4
https://pubmed.ncbi.nlm.nih.gov/33743211
https://pubmed.ncbi.nlm.nih.gov/33743211
Autor:
Jesse M. Engreitz, Lingli Wang, Dan Li, Shalina Taylor, Tsutomu Shinohara, James Chappell, Howard Y. Chang, Marlene Rabinovitch, Minyi Shi, Joseph Nasser, Daniel H. Mai, Fan Zhang, Ross J. Metzger, Jan-Renier A. J. Moonen, Michael Snyder, Maxwell R. Mumbach
Physiologic laminar shear stress (LSS) induces an endothelial gene expression profile that is vasculo-protective. In this report, we delineate how LSS mediates changes in the epigenetic landscape to promote this beneficial response. We show that unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbf064ebf1b7744ea8f44948606b40aa
https://doi.org/10.1101/2020.07.10.195768
https://doi.org/10.1101/2020.07.10.195768
Autor:
Jan-Renier Moonen, James Chappell, Minyi Shi, Tsutomu Shinohara, Dan Li, Maxwell R. Mumbach, Fan Zhang, Ramesh V. Nair, Joseph Nasser, Daniel H. Mai, Shalina Taylor, Lingli Wang, Ross J. Metzger, Howard Y. Chang, Jesse M. Engreitz, Michael P. Snyder, Marlene Rabinovitch
Publikováno v:
Nature communications. 13(1)
Physiologic laminar shear stress (LSS) induces an endothelial gene expression profile that is vasculo-protective. In this report, we delineate how LSS mediates changes in the epigenetic landscape to promote this beneficial response. We show that unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f761e41267e01dec5012e3ffdb5b95ac
https://pubmed.ncbi.nlm.nih.gov/35999210
https://pubmed.ncbi.nlm.nih.gov/35999210