Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Maxwell P. Gold"'
Autor:
David R. Ghasemi, Konstantin Okonechnikov, Anne Rademacher, Stephan Tirier, Kendra K. Maass, Hanna Schumacher, Piyush Joshi, Maxwell P. Gold, Julia Sundheimer, Britta Statz, Ahmet S. Rifaioglu, Katharina Bauer, Sabrina Schumacher, Michele Bortolomeazzi, Felice Giangaspero, Kati J. Ernst, Steven C. Clifford, Julio Saez-Rodriguez, David T. W. Jones, Daisuke Kawauchi, Ernest Fraenkel, Jan-Philipp Mallm, Karsten Rippe, Andrey Korshunov, Stefan M. Pfister, Kristian W. Pajtler
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Medulloblastomas with extensive nodularity are cerebellar tumors characterized by two distinct compartments and variable disease progression. The mechanisms governing the balance between proliferation and differentiation in MBEN remain poorl
Externí odkaz:
https://doaj.org/article/73c7a67e39074505ad2f97eb63756762
Autor:
Maxwell P. Gold, Winnie Ong, Andrew M. Masteller, David R. Ghasemi, Julie Anne Galindo, Noel R. Park, Nhan C. Huynh, Aneesh Donde, Veronika Pister, Raul A. Saurez, Maria C. Vladoiu, Grace H. Hwang, Tanja Eisemann, Laura K. Donovan, Adam D. Walker, Joseph Benetatos, Christelle Dufour, Livia Garzia, Rosalind A. Segal, Robert J. Wechsler-Reya, Jill P. Mesirov, Andrey Korshunov, Kristian W. Pajtler, Scott L. Pomeroy, Olivier Ayrault, Shawn M. Davidson, Jennifer A. Cotter, Michael D. Taylor, Ernest Fraenkel
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Many genes that drive normal cellular development also contribute to oncogenesis. Medulloblastoma (MB) tumors likely arise from neuronal progenitors in the cerebellum, and we hypothesized that the heterogeneity observed in MBs with sonic hed
Externí odkaz:
https://doaj.org/article/7e7b389f322c4aed99ee994b5589418d
Autor:
David R. Ghasemi, Konstantin Okonechnikov, Anne Rademacher, Stephan Tirier, Kendra K. Maass, Hanna Schumacher, Piyush Joshi, Maxwell P. Gold, Julia Sundheimer, Britta Statz, Ahmet S. Rifaioglu, Katharina Bauer, Sabrina Schumacher, Michele Bortolomeazzi, Felice Giangaspero, Kati J. Ernst, Steven C. Clifford, Julio Saez-Rodriguez, David T. W. Jones, Daisuke Kawauchi, Ernest Fraenkel, Jan-Philipp Mallm, Karsten Rippe, Andrey Korshunov, Stefan M. Pfister, Kristian W. Pajtler
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/47da4125f4844105ae9c15e274201e59
Autor:
Addison Gearhart, Sunakshi Bassi, Rahul H. Rathod, Rebecca S. Beroukhim, Stuart Lipsitz, Maxwell P. Gold, David M. Harrild, Audrey Dionne, Sunil J. Ghelani
Publikováno v:
Journal of Cardiovascular Magnetic Resonance, Vol 26, Iss 2, Pp 101060- (2024)
Background: Individuals with a Fontan circulation encompass a heterogeneous group with adverse outcomes linked to ventricular dilation, dysfunction, and dyssynchrony. The purpose of this study was to assess if unsupervised machine learning cluster an
Externí odkaz:
https://doaj.org/article/59249554e8554ed3b57ca3aa9cbb6e61
Autor:
Ryan G. Lim, Osama Al-Dalahmah, Jie Wu, Maxwell P. Gold, Jack C. Reidling, Guomei Tang, Miriam Adam, David K. Dansu, Hye-Jin Park, Patrizia Casaccia, Ricardo Miramontes, Andrea M. Reyes-Ortiz, Alice Lau, Richard A. Hickman, Fatima Khan, Fahad Paryani, Alice Tang, Kenneth Ofori, Emily Miyoshi, Neethu Michael, Nicolette McClure, Xena E. Flowers, Jean Paul Vonsattel, Shawn Davidson, Vilas Menon, Vivek Swarup, Ernest Fraenkel, James E. Goldman, Leslie M. Thompson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-23 (2022)
Here the authors evaluate single cell gene expression from mouse and human Huntington’s disease brains, finding incomplete oligodendrocyte maturation and pathways involved. Treating mice with thiamine/biotin ameliorates molecular pathology.
Externí odkaz:
https://doaj.org/article/3ad164ee693049358f658929a36c0698
Autor:
Charlene Smith-Geater, Sarah J. Hernandez, Ryan G. Lim, Miriam Adam, Jie Wu, Jennifer T. Stocksdale, Brook T. Wassie, Maxwell Philip Gold, Keona Q. Wang, Ricardo Miramontes, Lexi Kopan, Iliana Orellana, Shona Joy, Paul J. Kemp, Nicholas D. Allen, Ernest Fraenkel, Leslie M. Thompson
Publikováno v:
Stem Cell Reports, Vol 14, Iss 3, Pp 406-419 (2020)
Summary: Aberrant neuronal development and the persistence of mitotic cellular populations have been implicated in a multitude of neurological disorders, including Huntington's disease (HD). However, the mechanism underlying this potential pathology
Externí odkaz:
https://doaj.org/article/ec7c074fe8934cefbe2687c75ff40f03
Autor:
Addison Gearhart, Sunakshi Bassi, Rahul H. Rathod, Rebecca S. Beroukhim, Stuart Lipsitz, Maxwell P. Gold, David M. Harrild, Audrey Dionne, Sunil J. Ghelani
BackgroundVentricular dyssynchrony and its relationship to clinical outcomes is not well characterized in patients following Fontan palliation.MethodsSingle-center retrospective analysis of cardiac magnetic resonance (CMR) imaging of patients with a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c06eb26d310113d079c7b6d095451843
https://doi.org/10.1101/2023.02.27.23286545
https://doi.org/10.1101/2023.02.27.23286545
Autor:
Maxwell P. Gold, Winnie Ong, Andrew M. Masteller, Julie Anne Galindo, Noel R. Park, Raul A. Saurez, Maria C. Vladoiu, Laura K. Donovan, Adam D. Walker, Joseph Benetatos, Livia Garzia, Robert J. Wechsler-Reya, Jill P. Mesirov, Andrey Korshunov, Scott L. Pomeroy, Shawn M. Davidson, Jennifer A. Cotter, Michael D. Taylor, Ernest Fraenkel
Medulloblastoma (MB) is one of the most common malignant pediatric brain tumors. The sonic hedgehog (SHH) subtype accounts for 30% of MB cases and likely arises from mutations in granule cell precursors (GCPs), neuronal progenitors of the cerebellar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18bb0b4276e53da5f5ccaca99a689543
https://doi.org/10.1101/2022.09.02.506110
https://doi.org/10.1101/2022.09.02.506110
Autor:
Ryan G. Lim, Osama Al-Dalahmah, Jie Wu, Maxwell P. Gold, Jack C. Reidling, Guomei Tang, Miriam Adam, David Dansu, Hye-Jin Park, Patricia Casaccia, Ricardo Miramontes, Andrea M. Reyes-Ortiz, Alice Lau, Fatima Khan, Fahad Paryani, Alice Tang, Kenneth Ofori, Emily Miyoshi, Neethu Michael, Nicolette Geller, Xena E. Flowers, Jean Paul Vonsattel, Shawn Davidson, Vilas Menon, Vivek Swarup, Ernest Fraenkel, James E. Goldman, Leslie M. Thompson
The complexity of affected brain regions and cell types is a challenge for Huntington’s disease (HD) treatment. Here we used single nucleus RNA sequencing (snRNAseq) to investigate mechanism of pathology in the cortex and striatum from R6/2 mice at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0ebad05ce331099cbb5dee8839f881a
https://doi.org/10.1101/2022.06.27.497613
https://doi.org/10.1101/2022.06.27.497613
Autor:
Ryan G. Lim, Osama Al-Dalahmah, Jie Wu, Maxwell P. Gold, Jack C. Reidling, Guomei Tang, Miriam Adam, David K. Dansu, Hye-Jin Park, Patrizia Casaccia, Ricardo Miramontes, Andrea M. Reyes-Ortiz, Alice Lau, Richard A. Hickman, Fatima Khan, Fahad Paryani, Alice Tang, Kenneth Ofori, Emily Miyoshi, Neethu Michael, Nicolette McClure, Xena E. Flowers, Jean Paul Vonsattel, Shawn Davidson, Vilas Menon, Vivek Swarup, Ernest Fraenkel, James E. Goldman, Leslie M. Thompson
Publikováno v:
Nature communications, vol 13, iss 1
The complexity of affected brain regions and cell types is a challenge for Huntington’s disease (HD) treatment. Here we use single nucleus RNA sequencing to investigate molecular pathology in the cortex and striatum from R6/2 mice and human HD post