Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Maxwell I. Zimmerman"'
Autor:
Matthew A. Cruz, Thomas E. Frederick, Upasana L. Mallimadugula, Sukrit Singh, Neha Vithani, Maxwell I. Zimmerman, Justin R. Porter, Katelyn E. Moeder, Gaya K. Amarasinghe, Gregory R. Bowman
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Many viral proteins are thought to be unlikely candidates for drug discovery as they lack obvious drug binding sites. Here, the authors use computational approaches followed by experimental validation to identify a cryptic pocket within the Ebola vir
Externí odkaz:
https://doaj.org/article/b1138d9e9bae403da917984ac9c6ee9b
Autor:
Michael D. Ward, Maxwell I. Zimmerman, Artur Meller, Moses Chung, S. J. Swamidass, Gregory R. Bowman
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Comparing and contrasting structural ensembles of different protein variants helps connect specific structural features to a protein’s biochemical properties. Here, the authors propose DiffNets, a self-supervised, deep learning method that streamli
Externí odkaz:
https://doaj.org/article/13c6be6650f24dc28b6a7660d1256cac
Autor:
Jasmine Cubuk, Jhullian J. Alston, J. Jeremías Incicco, Sukrit Singh, Melissa D. Stuchell-Brereton, Michael D. Ward, Maxwell I. Zimmerman, Neha Vithani, Daniel Griffith, Jason A. Wagoner, Gregory R. Bowman, Kathleen B. Hall, Andrea Soranno, Alex S. Holehouse
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
SARS-CoV-2 nucleocapsid (N) protein is responsible for viral genome packaging. Here the authors employ single-molecule spectroscopy with all-atom simulations to provide the molecular details of N protein and show that it undergoes phase separation wi
Externí odkaz:
https://doaj.org/article/dd6a306bbe1846f28cbf4f152c659197
Autor:
Wenjie Wang, Woo-Jin Shin, Bojie Zhang, Younho Choi, Ji-Seung Yoo, Maxwell I. Zimmerman, Thomas E. Frederick, Gregory R. Bowman, Michael L. Gross, Daisy W. Leung, Jae U. Jung, Gaya K. Amarasinghe
Publikováno v:
Cell Reports, Vol 30, Iss 1, Pp 153-163.e5 (2020)
Summary: Severe fever with thrombocytopenia syndrome virus (SFTSV) is a tick-borne virus with 12%–30% case mortality rates and is related to the Heartland virus (HRTV) identified in the United States. Together, SFTSV and HRTV are emerging segmented
Externí odkaz:
https://doaj.org/article/7cbd66fb560d401da468d805028c6853
Autor:
Maxwell I. Zimmerman, Kathryn M. Hart, Carrie A. Sibbald, Thomas E. Frederick, John R. Jimah, Catherine R. Knoverek, Niraj H. Tolia, Gregory R. Bowman
Publikováno v:
ACS Central Science, Vol 3, Iss 12, Pp 1311-1321 (2017)
Externí odkaz:
https://doaj.org/article/74ea6caeaaeb48979b0f3c73141052a4
Autor:
Melissa D. Stuchell-Brereton, Maxwell I. Zimmerman, Justin J. Miller, Upasana L. Mallimadugula, J. Jeremías Incicco, Debjit Roy, Louis G. Smith, Jasmine Cubuk, Berevan Baban, Gregory T. DeKoster, Carl Frieden, Gregory R. Bowman, Andrea Soranno
Publikováno v:
Proceedings of the National Academy of Sciences. 120
The ε4-allele variant of apolipoprotein E (ApoE4) is the strongest genetic risk factor for Alzheimer’s disease, although it only differs from its neutral counterpart ApoE3 by a single amino acid substitution. While ApoE4 influences the formation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::982d41c6d061a85d64b3f74b0017d55a
https://doi.org/10.1073/pnas.2215371120
https://doi.org/10.1073/pnas.2215371120
Autor:
Kevin O. Tamadonfar, Gisela Di Venanzio, Jerome S. Pinkner, Karen W. Dodson, Vasilios Kalas, Maxwell I. Zimmerman, Jesus Bazan Villicana, Gregory R. Bowman, Mario F. Feldman, Scott J. Hultgren
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Multidrug-resistant Acinetobacter baumannii infections are an urgent clinical problem and can cause difficult-to-treat nosocomial infections. During such infections, like catheter-associated urinary tract infections (CAUTI), A. baumannii rely on adhe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af4b803630bfc85dac2e68688f455d74
https://doi.org/10.1073/pnas.2212694120
https://doi.org/10.1073/pnas.2212694120
Autor:
Yingye Fang, Thomas P. Burris, Antonina I. Frolova, P. I. Imoukhuede, Sarah K. England, Michael D. Ward, Thomas Koelblen, Gregory R. Bowman, Maxwell I. Zimmerman, Justin R. Porter, Manasi Malik, Michelle Roh
Publikováno v:
ACS Pharmacology & Translational Science. 4:1543-1555
The hormone oxytocin is commonly administered during childbirth to initiate and strengthen uterine contractions and prevent postpartum hemorrhage. However, patients have wide variation in the oxytocin dose required for a clinical response. To begin t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b2abf014234762401fa66e4042c4328
https://doi.org/10.1021/acsptsci.1c00095
https://doi.org/10.1021/acsptsci.1c00095
Autor:
Sukrit Singh, Catherine E. Kuhn, Aoife M. Harbison, Vincent A. Voelz, John D. Chodera, Justin R. Porter, Neha Vithani, Joseph E. Coffland, Rafal P. Wiewiora, Artur Meller, Carl A Fogarty, Maxwell I. Zimmerman, Jonathan H. Borowsky, Gregory R. Bowman, Michael D. Ward, Matthew F. D. Hurley, Elisa Fadda, Upasana L. Mallimadugula
Publikováno v:
Nature Chemistry. 13:651-659
SARS-CoV-2 has intricate mechanisms for initiating infection, immune evasion/suppression and replication that depend on the structure and dynamics of its constituent proteins. Many protein structures have been solved, but far less is known about thei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::616c72101f8be9aa1b5000974b96797a
https://doi.org/10.1038/s41557-021-00707-0
https://doi.org/10.1038/s41557-021-00707-0
Autor:
Melissa D. Stuchell-Brereton, Maxwell I. Zimmerman, Justin J. Miller, Upasana L. Mallimadugula, J. Jeremias Incicco, Debjit Roy, Louis G. Smith, Berevan Baban, Gregory T. DeKoster, Carl Frieden, Gregory R. Bowman, Andrea Soranno
The ε4-allele variant of Apolipoprotein E (ApoE4) is the strongest genetic risk factor for Alzheimer’s disease, though it only differs from its neutral counterpart ApoE3 by a single amino acid substitution. While ApoE4 influences the formation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7150579344a81feb2ed19d91697f30c4
https://doi.org/10.1101/2022.02.02.478828
https://doi.org/10.1101/2022.02.02.478828
