Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Maxinne, Watchon"'
Autor:
Maxinne Watchon, Amanda L. Wright, Holly I. Ahel, Katherine J. Robinson, Stuart K. Plenderleith, Andrea Kuriakose, Kristy C. Yuan, Angela S. Laird
Publikováno v:
Molecular Brain, Vol 17, Iss 1, Pp 1-15 (2024)
Abstract Machado-Joseph disease (MJD), also known as spinocerebellar ataxia type 3, is a fatal neurodegenerative disease that causes loss of balance and motor co-ordination, eventually leading to paralysis. It is caused by the autosomal dominant inhe
Externí odkaz:
https://doaj.org/article/6f50372d2c4746069222f52115dcf314
Autor:
Maxinne Watchon, Luan Luu, Katherine J. Robinson, Kristy C. Yuan, Alana De Luca, Hannah J. Suddull, Madelaine C. Tym, Gilles J. Guillemin, Nicholas J. Cole, Garth A. Nicholson, Roger S. Chung, Albert Lee, Angela S. Laird
Publikováno v:
Molecular Brain, Vol 14, Iss 1, Pp 1-16 (2021)
Abstract Machado-Joseph disease (MJD, also known as spinocerebellar ataxia type 3) is a fatal neurodegenerative disease that impairs control and coordination of movement. Here we tested whether treatment with the histone deacetylase inhibitor sodium
Externí odkaz:
https://doaj.org/article/c4c31cfe9850482096f4f4f803675be2
Publikováno v:
Cells, Vol 12, Iss 6, p 893 (2023)
Background: Spinocerebellar ataxia 3 (SCA3, also known as Machado Joseph disease) is a fatal neurodegenerative disease caused by the expansion of the trinucleotide repeat region within the ATXN3/MJD gene. The presence of this genetic expansion result
Externí odkaz:
https://doaj.org/article/2075cc6e9aed4df8bef93e84a7808f11
Autor:
Katherine J. Robinson, Madelaine C. Tym, Alison Hogan, Maxinne Watchon, Kristy C. Yuan, Stuart K. Plenderleith, Emily K. Don, Angela S. Laird
Publikováno v:
Disease Models & Mechanisms, Vol 14, Iss 10 (2021)
Spinocerebellar ataxia 3 (SCA3, also known as Machado–Joseph disease) is a neurodegenerative disease caused by inheritance of a CAG repeat expansion within the ATXN3 gene, resulting in polyglutamine (polyQ) repeat expansion within the ataxin-3 prot
Externí odkaz:
https://doaj.org/article/58a28b3fec1546bcae968ee506d3ac17
Autor:
Flora Cheng, Alana De Luca, Alison L. Hogan, Stephanie L. Rayner, Jennilee M. Davidson, Maxinne Watchon, Claire H. Stevens, Sonia Sanz Muñoz, Lezanne Ooi, Justin J. Yerbury, Emily K. Don, Jennifer A. Fifita, Maria D. Villalva, Hannah Suddull, Tyler R. Chapman, Thomas J. Hedl, Adam K. Walker, Shu Yang, Marco Morsch, Bingyang Shi, Ian P. Blair, Angela S. Laird, Roger S. Chung, Albert Lee
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
The past decade has seen a rapid acceleration in the discovery of new genetic causes of ALS, with more than 20 putative ALS-causing genes now cited. These genes encode proteins that cover a diverse range of molecular functions, including free radical
Externí odkaz:
https://doaj.org/article/6d9d5478214e4a43b5c90d1b2ff9a16b
Autor:
Pradeep Manuneedhi Cholan, Alvin Han, Brad R Woodie, Maxinne Watchon, Angela RM Kurz, Angela S Laird, Warwick J Britton, Lihua Ye, Zachary C Holmes, Jessica R McCann, Lawrence A David, John F Rawls, Stefan H Oehlers
Publikováno v:
Gut Microbes, Vol 12, Iss 1 (2020)
Short-chain fatty acids (SCFAs) are produced by microbial fermentation of dietary fiber in the gut. Butyrate is a particularly important SCFA with anti-inflammatory properties and is generally present at lower levels in inflammatory diseases associat
Externí odkaz:
https://doaj.org/article/2175f10d9d4f41ef94e9d5809bbe0133
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
The spinocerebellar ataxias (SCAs) are a heterogeneous group of neurodegenerative diseases that share convergent disease features. A common symptom of these diseases is development of ataxia, involving impaired balance and motor coordination, usually
Externí odkaz:
https://doaj.org/article/3974b180fecd40d7a5bdfbd737b2a832
Publikováno v:
Cells, Vol 10, Iss 10, p 2592 (2021)
Spinocerebellar ataxia type 3 (SCA3) is a hereditary ataxia caused by inheritance of a mutated form of the human ATXN3 gene containing an expanded CAG repeat region, encoding a human ataxin-3 protein with a long polyglutamine (polyQ) repeat region. P
Externí odkaz:
https://doaj.org/article/be38f70e022342efa83d89988eed3193
Autor:
Jamie R. Acosta, Maxinne Watchon, Kristy C. Yuan, Jennifer A. Fifita, Adam J. Svahn, Emily K. Don, Claire G. Winnick, Ian P. Blair, Garth A. Nicholson, Nicholas J. Cole, Claire Goldsbury, Angela S. Laird
Publikováno v:
Biology Open, Vol 7, Iss 10 (2018)
We describe a protocol for culturing neurons from transgenic zebrafish embryos to investigate the subcellular distribution and protein aggregation status of neurodegenerative disease-causing proteins. The utility of the protocol was demonstrated on c
Externí odkaz:
https://doaj.org/article/0f9782bd2e3e47418a35208188f6cfb8
Autor:
Mahkameh Abeditashi, Katherine J. Robinson, Jacob Helm, Thorsten Schmidt, Olaf Riess, Jonasz J. Weber, Zinah Wassouf, Stefan Hauser, Ludger Schöls, Jana Schmidt, Maxinne Watchon, Angela S. Laird, Priscila Pereira Sena, Jeannette Hübener-Schmid
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America 118(47), e2025810118 (2021). doi:10.1073/pnas.2025810118
Aberrant O-GlcNAcylation, a protein posttranslational modification defined by the O-linked attachment of the monosaccharide N-acetylglucosamine (O-GlcNAc), has been implicated in neurodegenerative diseases. However, although many neuronal proteins ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::850e1e42f506abfc7e7a1e2276b8f487
https://doi.org/10.1073/pnas.2025810118
https://doi.org/10.1073/pnas.2025810118