Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Maxine Silvestrov"'
Autor:
Moritz Schütte, Thomas Risch, Nilofar Abdavi-Azar, Karsten Boehnke, Dirk Schumacher, Marlen Keil, Reha Yildiriman, Christine Jandrasits, Tatiana Borodina, Vyacheslav Amstislavskiy, Catherine L. Worth, Caroline Schweiger, Sandra Liebs, Martin Lange, Hans- Jörg Warnatz, Lee M. Butcher, James E. Barrett, Marc Sultan, Christoph Wierling, Nicole Golob-Schwarzl, Sigurd Lax, Stefan Uranitsch, Michael Becker, Yvonne Welte, Joseph Lewis Regan, Maxine Silvestrov, Inge Kehler, Alberto Fusi, Thomas Kessler, Ralf Herwig, Ulf Landegren, Dirk Wienke, Mats Nilsson, Juan A. Velasco, Pilar Garin-Chesa, Christoph Reinhard, Stephan Beck, Reinhold Schäfer, Christian R. A. Regenbrecht, David Henderson, Bodo Lange, Johannes Haybaeck, Ulrich Keilholz, Jens Hoffmann, Hans Lehrach, Marie-Laure Yaspo
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-19 (2017)
The heterogeneity of colorectal cancer has important clinical and therapeutic implications. Here the authors analysed the responses of a large biobank of organoids and xenografts derived from colorectal patients to a panel of clinically relevant ther
Externí odkaz:
https://doaj.org/article/00f477ba693042c6918f1164e120c8e4
Heterogeneous pathway activation and drug response modelled in colorectal-tumor-derived 3D cultures.
Autor:
Dirk Schumacher, Geoffroy Andrieux, Karsten Boehnke, Marlen Keil, Alessandra Silvestri, Maxine Silvestrov, Ulrich Keilholz, Johannes Haybaeck, Gerrit Erdmann, Christoph Sachse, Markus Templin, Jens Hoffmann, Melanie Boerries, Reinhold Schäfer, Christian R A Regenbrecht
Publikováno v:
PLoS Genetics, Vol 15, Iss 3, p e1008076 (2019)
Organoid cultures derived from colorectal cancer (CRC) samples are increasingly used as preclinical models for studying tumor biology and the effects of targeted therapies under conditions capturing in vitro the genetic make-up of heterogeneous and e
Externí odkaz:
https://doaj.org/article/4a7ae2e6be5340cd9102d8eb799ab595
Autor:
Reinhold Schäfer, G. Erdmann, Christian R A Regenbrecht, Geoffroy Andrieux, Christoph Sachse, Johannes Haybaeck, Markus F. Templin, Melanie Boerries, Alessandra Silvestri, Jens Hoffmann, Marlen Keil, Ulrich Keilholz, Maxine Silvestrov, Karsten Boehnke, Dirk Schumacher
Publikováno v:
PLoS Genetics, Vol 15, Iss 3, p e1008076 (2019)
PLoS Genetics
PLoS Genetics
Organoid cultures derived from colorectal cancer (CRC) samples are increasingly used as preclinical models for studying tumor biology and the effects of targeted therapies under conditions capturing in vitro the genetic make-up of heterogeneous and e
Autor:
Maxine Silvestrov, Jens Hoffmann, Christoph Reinhard, Christian R. A. Regenbrecht, Dirk Schumacher, Reinhold Schäfer, Alessandra Silvestri, Karsten Boehnke
Publikováno v:
Mechanisms of Molecular Carcinogenesis – Volume 2 ISBN: 9783319536606
For decades of molecular cancer research, immortal cancer cell lines have served as an easily accessible source for basic cancer biology research and preclinical testing of anticancer drugs. However, numerous studies have suggested that these cell li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6eeff65d3eb7da6c1002ffb7915e38aa
https://doi.org/10.1007/978-3-319-53661-3_14
https://doi.org/10.1007/978-3-319-53661-3_14
Autor:
Catherine L. Worth, Vyacheslav Amstislavskiy, Yvonne Welte, Lee M. Butcher, Tatiana Borodina, Jens Hoffmann, Christoph Wierling, Christian R. A. Regenbrecht, Sandra Liebs, Caroline Schweiger, Moritz Schütte, Juan A. Velasco, Martin Lange, David Henderson, Marc Sultan, Johannes Haybaeck, Michael Becker, Maxine Silvestrov, Christoph Reinhard, Christine Jandrasits, Karsten Boehnke, Nicole Golob-Schwarzl, Sigurd Lax, Mats Nilsson, Marie-Laure Yaspo, Thomas Kessler, Reha Yildiriman, Ulrich Keilholz, Hans-Jörg Warnatz, Pilar Garin-Chesa, Stefan Uranitsch, Bodo Lange, Dirk Wienke, Nilofar Abdavi-Azar, Dirk Schumacher, Ralf Herwig, James E. Barrett, Stephan Beck, Inge Kehler, Thomas Risch, Alberto Fusi, Hans Lehrach, Ulf Landegren, Marlen Keil, Reinhold Schäfer, Joseph L. Regan
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-19 (2017)
Nature Communications
Schutte, M, Risch, T, Abdavi-Azar, N, Boehnke, K, Schumacher, D, Keil, M, Yildiriman, R, Jandrasits, C, Borodina, T, Amstislavskiy, V, Worth, C L, Schweiger, C, Liebs, S, Lange, M, Warnatz, H J, Butcher, L M, Barrett, J E, Sultan, M, Wierling, C, Golob-Schwarzl, N, Lax, S, Uranitsch, S, Becker, M, Welte, Y, Regan, J L, Silvestrov, M, Kehler, I, Fusi, A, Kessler, T, Herwig, R, Landegren, U, Wienke, D, Nilsson, M, Velasco, J A, Garin-Chesa, P, Reinhard, C, Beck, S, Schäfer, R, Regenbrecht, C R A, Henderson, D, Lange, B, Haybaeck, J, Keilholz, U, Hoffmann, J, Lehrach, H & Yaspo, M-L 2017, ' Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors ', Nature Communications, vol. 8, 14262, pp. 1-19 . https://doi.org/10.1038/ncomms14262
Nature Communications
Schutte, M, Risch, T, Abdavi-Azar, N, Boehnke, K, Schumacher, D, Keil, M, Yildiriman, R, Jandrasits, C, Borodina, T, Amstislavskiy, V, Worth, C L, Schweiger, C, Liebs, S, Lange, M, Warnatz, H J, Butcher, L M, Barrett, J E, Sultan, M, Wierling, C, Golob-Schwarzl, N, Lax, S, Uranitsch, S, Becker, M, Welte, Y, Regan, J L, Silvestrov, M, Kehler, I, Fusi, A, Kessler, T, Herwig, R, Landegren, U, Wienke, D, Nilsson, M, Velasco, J A, Garin-Chesa, P, Reinhard, C, Beck, S, Schäfer, R, Regenbrecht, C R A, Henderson, D, Lange, B, Haybaeck, J, Keilholz, U, Hoffmann, J, Lehrach, H & Yaspo, M-L 2017, ' Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors ', Nature Communications, vol. 8, 14262, pp. 1-19 . https://doi.org/10.1038/ncomms14262
Colorectal carcinoma represents a heterogeneous entity, with only a fraction of the tumours responding to available therapies, requiring a better molecular understanding of the disease in precision oncology. To address this challenge, the OncoTrack c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42d73ec2fac88333758e141522ab23ec
https://doi.org/10.17169/refubium-24207
https://doi.org/10.17169/refubium-24207
Autor:
Carsten Denkert, Guido Gambara, Alessandra Silvestri, Philipp Jurmeister, Christian R. A. Regenbrecht, Olga Gorea, Jens-Uwe Blohmer, Ulrich Keilholz, V Kiver, C Schweiger, Maxine Silvestrov
Publikováno v:
Cancer Research. 78:5013-5013
Targeted treatment for breast cancer subsets currently relies on the occurrence of estrogen, progesterone and Her2/neu receptors. For triple negative breast cancer (TNBC) there is no identified targeted therapy. The mutational landscape for breast ca
Autor:
Marlen Keil, Reinhold Schaefer, Christian R. A. Regenbrecht, Dirk Schumacher, Iduna Fichtner, Jens Hoffman, Alessandra Silvestri, Maxine Silvestrov, Karsten Boehnke
Publikováno v:
Cancer Research. 76:2412-2412
Precision medicine approaches seeking to predict individual susceptibility to single or combinatorial drugs for advanced and/or metastasized solid cancers heavily depend on biological model systems that maintain key morphological, phenotypic and geno