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of 2
pro vyhledávání: '"Maxine L. Wang"'
Autor:
Alina Guna, Katharine R. Page, Joseph M. Replogle, Theodore K. Esantsi, Maxine L. Wang, Jonathan S. Weissman, Rebecca M. Voorhees
Publikováno v:
BMC Genomics, Vol 24, Iss 1, Pp 1-13 (2023)
Abstract Mapping genetic interactions is essential for determining gene function and defining novel biological pathways. We report a simple to use CRISPR interference (CRISPRi) based platform, compatible with Fluorescence Activated Cell Sorting (FACS
Externí odkaz:
https://doaj.org/article/595c5032f9dd4a8ca48b4d5775c55fa0
Autor:
Alina Guna, Taylor A. Stevens, Alison J. Inglis, Joseph M. Replogle, Theodore K. Esantsi, Gayathri Muthukumar, Kelly C. L. Shaffer, Maxine L. Wang, Angela N. Pogson, Jeff J. Jones, Brett Lomenick, Tsui-Fen Chou, Jonathan S. Weissman, Rebecca M. Voorhees
Publikováno v:
Science (New York, N.Y.). 378(6617)
In the mitochondrial outer membrane, tail-anchored (TA) proteins play critical roles in cytoplasmic-mitochondrial communication. Using genome-wide CRISPRi screens, we identify factors involved in mitochondrial TA biogenesis in human cells. We show th