Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Maxine Allen"'
Autor:
Laurel D. Edmunds, Silvia Gluderer, Pavel V. Ovseiko, Roel Kamerling, Jacqueline Ton, Laura Vis, Mario Jenni, Gregory Tutton, Helen Lawton-Smith, Márta Völgyiné Nadabán, Máté Rab, Jon Rees, John Anson, Alexander D. Rushforth, Maxine Allen, Alastair M. Buchan, Montserrat Vendrell, Alex Casta, Gábor Mehes, Pancras C. W. Hogendoorn, Ernst Hafen, A. Bassim Hassan
Publikováno v:
Health Research Policy and Systems, Vol 17, Iss 1, Pp 1-15 (2019)
Abstract Background While the European Union is striving to become the ‘Innovation Union’, there remains a lack of quantifiable indicators to compare and benchmark regional innovation clusters. To address this issue, a HealthTIES (Healthcare, Tec
Externí odkaz:
https://doaj.org/article/3546e1820ffd45febfc5fd55d1cd9125
Autor:
Josine L Min, George Nicholson, Ingileif Halgrimsdottir, Kristian Almstrup, Andreas Petri, Amy Barrett, Mary Travers, Nigel W Rayner, Reedik Mägi, Fredrik H Pettersson, John Broxholme, Matt J Neville, Quin F Wills, Jane Cheeseman, GIANT Consortium, MolPAGE Consortium, Maxine Allen, Chris C Holmes, Tim D Spector, Jan Fleckner, Mark I McCarthy, Fredrik Karpe, Cecilia M Lindgren, Krina T Zondervan
Publikováno v:
PLoS Genetics, Vol 8, Iss 2, p e1002505 (2012)
Metabolic Syndrome (MetS) is highly prevalent and has considerable public health impact, but its underlying genetic factors remain elusive. To identify gene networks involved in MetS, we conducted whole-genome expression and genotype profiling on abd
Externí odkaz:
https://doaj.org/article/48c00fdd38354c18b5237e49bea1cf97
Autor:
George Nicholson, Mattias Rantalainen, Jia V Li, Anthony D Maher, Daniel Malmodin, Kourosh R Ahmadi, Johan H Faber, Amy Barrett, Josine L Min, N William Rayner, Henrik Toft, Maria Krestyaninova, Juris Viksna, Sudeshna Guha Neogi, Marc-Emmanuel Dumas, Ugis Sarkans, MolPAGE Consortium, Peter Donnelly, Thomas Illig, Jerzy Adamski, Karsten Suhre, Maxine Allen, Krina T Zondervan, Tim D Spector, Jeremy K Nicholson, John C Lindon, Dorrit Baunsgaard, Elaine Holmes, Mark I McCarthy, Chris C Holmes
Publikováno v:
PLoS Genetics, Vol 7, Iss 9, p e1002270 (2011)
We have performed a metabolite quantitative trait locus (mQTL) study of the (1)H nuclear magnetic resonance spectroscopy ((1)H NMR) metabolome in humans, building on recent targeted knowledge of genetic drivers of metabolic regulation. Urine and plas
Externí odkaz:
https://doaj.org/article/1c14554088b5407e99f8d8f2207e1483
Autor:
Mattias Rantalainen, Blanca M Herrera, George Nicholson, Rory Bowden, Quin F Wills, Josine L Min, Matt J Neville, Amy Barrett, Maxine Allen, Nigel W Rayner, Jan Fleckner, Mark I McCarthy, Krina T Zondervan, Fredrik Karpe, Chris C Holmes, Cecilia M Lindgren
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27338 (2011)
To understand how miRNAs contribute to the molecular phenotype of adipose tissues and related traits, we performed global miRNA expression profiling in subcutaneous abdominal and gluteal adipose tissue of 70 human subjects and characterised which miR
Externí odkaz:
https://doaj.org/article/d2cb4510af2f40deb759996a4e17e510
Autor:
N W Rayner, Christopher Holmes, Josine L. Min, Mark I. McCarthy, George Nicholson, Blanca M. Herrera, Krina T. Zondervan, Mattias Rantalainen, Amy Barrett, Matt J. Neville, Maxine Allen, Quin F. Wills, Rory Bowden, Jan Fleckner, Cecilia M. Lindgren, Fredrik Karpe
Publikováno v:
PLoS ONE
PLoS ONE, Vol 6, Iss 11, p e27338 (2011)
PLoS ONE, Vol 6, Iss 11, p e27338 (2011)
To understand how miRNAs contribute to the molecular phenotype of adipose tissues and related traits, we performed global miRNA expression profiling in subcutaneous abdominal and gluteal adipose tissue of 70 human subjects and characterised which miR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::693eeab04082d011891e8f2f12f12bd3
https://doi.org/10.1371/journal.pone.0027338
https://doi.org/10.1371/journal.pone.0027338
Autor:
Alisoun H. Carey, Maxine Allen
Publikováno v:
Drug Discovery Today: TARGETS. 3:183-190
Drug target selection and validation is the goal of commercial genetic research. Human studies are beginning to deliver on their early promise of identifying complex disease susceptibility genes as the first step in validating potential new targets.
Autor:
Peter Kovacs, Angela Döring, Frank Geller, Lenka Foretova, Dana Mates, Paul M. Ridker, Francesco Mauri, Mark J. Caulfield, Nora Franceschini, Neonilia Szeszenia-Dabrowska, Toshiko Tanaka, Pagona Lagiou, Jennifer E. Huffman, Paul Scheet, Gudmar Thorleifsson, Jacqueline M. Vink, Nicole Vogelzangs, Ida Surakka, Jeffrey R. Gulcher, Ulrich John, Veikko Salomaa, Eco J. C. de Geus, Hakon Hakonarson, Anne Barton, Luigi Barzan, H.-Erich Wichmann, Anneli Pouta, Peter Vollenweider, Kristina Kjærheim, Jed E. Rose, Ruth J. F. Loos, Susanne Lucae, Danielle Posthuma, Henning Tiemeier, Fangyi Gu, Mark I. McCarthy, Unnur Styrkarsdottir, James McKay, Talin Haritunians, Martin Preisig, Olle Melander, Xavier Castellsagué, William H. Matthai, Piera Angelica Merlini, Daniel I. Chasman, Michael Stumvoll, Ozren Polasek, Nilesh J. Samani, Søren Besenbacher, Jane Worthington, Daniel F. Gudbjartsson, Alistair S. Hall, Antonio Agudo, Keith Matthews, Gonçalo R. Abecasis, Jaana Laitinen, Norbert Dahmen, Robert W. Mahley, Mari Nelis, Inga Prokopenko, Anke Tönjes, Iris H Gudjonsdottir, Joshua W. Knowles, Jing Hua Zhao, Jouke-Jan Hottenga, Vincent Mooser, Jack Satsangi, Cristina Canova, Stephen P. Fortmann, Hreinn Stefansson, Manuela Uda, T. Brueckl, Mary Susan Burnett, Michael Boehnke, Veronique Vitart, Philip J. Barter, Ruth McPherson, Benjamin F. Voight, Patrick F. Sullivan, Pier Mannuccio Mannucci, Michael Wittig, Kari Stefansson, Lowell F. Satler, Eric Boerwinkle, Benjamin J. Wright, Ben A. Oostra, John Strauss, Stefania Bandinelli, S. Horstmann, Jonathan Marchini, Simone Benhamou, Stephen E. Epstein, Rajesh Rawal, Vladimir Janout, Miles Parkes, Liming Qu, Yuri Milaneschi, Peter Almgren, Kaisu Keskitalo, Matti Isohanni, Dan Rujescu, John P. A. Ioannidis, Peter Rudnai, Stefan Walter, Diego Ardissino, John B. Vincent, Leif Groop, Kent D. Taylor, Christopher J. O'Donnell, Christopher W. Knouff, David I. Conway, Thomas Quertermous, Joseph M. Lindsay, Stephen M. Schwartz, Tariq Ahmed, Jolanta Lissowska, Evan L. Thacker, Igor Rudan, Sreekumar G. Pillai, Janet Audrain-McGovern, Daniel Levy, S. Kathiresan, Timothy M. Frayling, Brenda W.J.H. Penninx, Shen Huei-Yi, Johannes H. Smit, Gonneke Willemsen, Henry Völzke, John R. B. Perry, Federica Tozzi, Roberto Elosua, Devin Absher, G B Walters, Augusto D. Pichard, Stephen J. Chanock, Katja K.H. Aben, Anna-Liisa Hartikainen, Maria Krestyaninova, Ivana Holcatova, Tim D. Spector, Ming D. Li, Xiangjun Xiao, Barbara McKnight, Hans J. Grabe, Martin den Heijer, Caroline Hayward, Unnur Thorsteinsdottir, Douglas F. Levinson, Claes Ladenvall, Robert L. Wilensky, Danyu Lin, Nicole Soranzo, Lefkos T. Middleton, Jason S. Liu, Wade H. Berrettini, Laura M. Thornton, Muredach P. Reilly, Jack M. Guralnik, Ron Waksman, Per Bakke, Alan F. Wright, Andre Franke, Thorgeir E. Thorgeirsson, Barbara Nitz, Anthony J. Balmforth, Jaspal S. Kooner, Gavin Lucas, Esther H. Lips, Helena Furberg, Albert Hofman, Patrick Sulem, Astrid Petersmann, Ivana Kolcic, Jaakko Tuomilehto, Lorenzo Richiardi, Pablo V. Gejman, Claire J. Steves, Thorarinn Tyrfingsson, Yurii S. Aulchenko, Brendan M. Everett, Ariana Znaor, Maxine Allen, Thorunn Rafnar, Mark Lathrop, Reedik Mägi, Kenneth M. Kent, M. Perola, Nicholas J. Wareham, Daniel J. Rader, John R. Thompson, Sarah R. Preis, Peter Kraft, Caryn Lerman, Hogni Oskarsson, Alan R. Sanders, Alexander Teumer, Xin Yuan, Cornelia M. van Duijn, Samuli Ripatti, André G. Uitterlinden, Carl A. Anderson, Martin Farrall, Kay-Tee Khaw, Joachim Heinrich, Heather M. Stringham, Bruce M. Psaty, Jaakko Kaprio, Valgerdur Steinthorsdottir, Steve Eyre, James F. Wilson, David J. Hunter, Johannes Kettunen, Wendy Thomson, Antero Kesäniemi, Karen L. Mohlke, Christian Gieger, Tatiana V. Macfarlane, Jubao Duan, Anne Farmer, Clyde Francks, Joshua C. Bis, Harry Campbell, Pierandrea Muglia, Andres Metspalu, Dawn M. Waterworth, Ramachandran S. Vasan, Hermine H. Maes, David Zaridze, Luisa Bernardinelli, Vladimir Bencko, Massimo Mangino, Lambertus A. Kiemeney, Solveig Gretarsdottir, Tõnu Esko, Anne U. Jackson, Claire M. Healy, Scott M. Grundy, David St Clair, Curt D. Furberg, Mingyao Li, Peter McGuffin, Christopher G. Mathew, David Altshuler, Dorret I. Boomsma, Susan Campbell, Jianxin Shi, Najaf Amin, James L. Kennedy, Ana M. Valdes, Anna F. Dominiczak, Themistocles L. Assimes, Susan E. Hankinson, Inês Barroso, Marjo-Riitta Järvelin, Guillaume Paré, Joe Devaney, Antonio Terracciano, David Schlessinger, Paul Brennan, Shih-Jen Hwang, Luigi Ferrucci, Ray Lowry, Jennifer Dackor, Eleonora Fabianova, Lina Zgaga, Emelia J. Benjamin, Fabio Busonero, Sarah H. Wild, Patricia B. Munroe, John C. Chambers, Carlos Iribarren, Marcus Ising, Yunjung Kim, Richard O. Day, Amund Gulsvik, Gérard Waeber, Claudia Lamina, Arne Schäfer
Publikováno v:
Translational Psychiatry, 3:e308. Nature Publishing Group
Scopus-Elsevier
Thorgeirsson, T E, Gudbjartsson, D F, Sulem, P, Besenbacher, S, Styrkarsdottir, U, Thorleifsson, G, Walters, G B, Furberg, H, Sullivan, P F, Marchini, J, McCarthy, M I, Steinthorsdottir, V, Thorsteinsdottir, U, Stefansson, K & TAG Consortium 2013, ' A common biological basis of obesity and nicotine addiction ', Translational Psychiatry, vol. 3, pp. e308 . https://doi.org/10.1038/tp.2013.81
Translational Psychiatry, 3
Transl. Psychiatry 3:e308 (2013)
Translational Psychiatry; Vol 3
Thorgeirsson, T E, Gudbjartsson, D F, Sulem, P, Besenbacher, S, Styrkarsdottir, U, Thorleifsson, G, Walters, G B, Furberg, H, Sullivan, P F, Marchini, J, McCarthy, M I, Steinthorsdottir, V, Thorsteinsdottir, U, Stefansson, K & Posthuma, D 2013, ' A common biological basis of obesity and nicotine addiction ', Translational Psychiatry, vol. 3, e308, pp. e308 . https://doi.org/10.1038/tp.2013.81
Translational Psychiatry
Scopus-Elsevier
Thorgeirsson, T E, Gudbjartsson, D F, Sulem, P, Besenbacher, S, Styrkarsdottir, U, Thorleifsson, G, Walters, G B, Furberg, H, Sullivan, P F, Marchini, J, McCarthy, M I, Steinthorsdottir, V, Thorsteinsdottir, U, Stefansson, K & TAG Consortium 2013, ' A common biological basis of obesity and nicotine addiction ', Translational Psychiatry, vol. 3, pp. e308 . https://doi.org/10.1038/tp.2013.81
Translational Psychiatry, 3
Transl. Psychiatry 3:e308 (2013)
Translational Psychiatry; Vol 3
Thorgeirsson, T E, Gudbjartsson, D F, Sulem, P, Besenbacher, S, Styrkarsdottir, U, Thorleifsson, G, Walters, G B, Furberg, H, Sullivan, P F, Marchini, J, McCarthy, M I, Steinthorsdottir, V, Thorsteinsdottir, U, Stefansson, K & Posthuma, D 2013, ' A common biological basis of obesity and nicotine addiction ', Translational Psychiatry, vol. 3, e308, pp. e308 . https://doi.org/10.1038/tp.2013.81
Translational Psychiatry
Contains fulltext : 128630.pdf (Publisher’s version ) (Open Access) Smoking influences body weight such that smokers weigh less than non-smokers and smoking cessation often leads to weight increase. The relationship between body weight and smoking
Autor:
Matt J. Neville, Quin F. Wills, Ingileif Halgrimsdottir, Jane Cheeseman, Christopher Holmes, Mary E. Travers, Reedik Mägi, Fredrik Pettersson, John Broxholme, Tim D. Spector, Cecilia M. Lindgren, Josine L. Min, Kristian Almstrup, Fredrik Karpe, Andreas Petri, Mark I. McCarthy, Krina T. Zondervan, Amy Barrett, Maxine Allen, George Nicholson, N W Rayner, Jan Fleckner
Publikováno v:
PLoS Genet. 8:e1002505 (2012)
PLoS Genetics
PLoS Genetics, Vol 8, Iss 2, p e1002505 (2012)
PLoS Genetics
PLoS Genetics, Vol 8, Iss 2, p e1002505 (2012)
Metabolic Syndrome (MetS) is highly prevalent and has considerable public health impact, but its underlying genetic factors remain elusive. To identify gene networks involved in MetS, we conducted whole-genome expression and genotype profiling on abd
Autor:
Matti Isohanni, Andrew C. Heath, Thomas Mueller, Mark I. McCarthy, Jose I. Mayordomo, Nilesh J. Samani, Hogni Oskarsson, Shen Huei-Yi, Gonneke Willemsen, Katja K.H. Aben, Leena Peltonen, Steinn Jonsson, Maria Krestyaninova, Jouke-Jan Hottenga, Kari Stefansson, Hreinn Stefansson, Markus Perola, Maria D. Garcia-Prats, Michael Stumvoll, Najaf Amin, Inga Prokopenko, Nicole Vogelzangs, Ida Surakka, Frank Geller, Massimo Mangino, Veikko Salomaa, Nicholas G. Martin, Ana M. Valdes, Jacqueline M. Vink, Iris H Gudjonsdottir, Patrick Sulem, Asger Dirksen, Albert Hofman, Lambertus A. Kiemeney, Pamela A. F. Madden, Thorarinn Tyrfingsson, Norbert Dahmen, Anke Tönjes, Christian Gieger, Jaana Laitinen, Alistair S. Hall, Meinhard Haltmayer, Reedik Mägi, Tim D. Spector, Maxine Allen, H-Erich Wichmann, Martin den Heijer, Jaakko Kaprio, Marjo-Riitta Järvelin, Stefan Walter, Peter Kovacs, Claire J. Steves, Rajesh Rawal, Berta Saez, Unnur Thorsteinsdottir, Brenda W.J.H. Penninx, Victoria Lezcano, Yurii S. Aulchenko, Johannes Kettunen, Anna-Liisa Hartikainen, Dorret I. Boomsma, Daniel F. Gudbjartsson, Andre M. van Rij, Kaisu Keskitalo, Thorunn Rafnar, Cornelia M. van Duijn, Samuli Ripatti, Wilbur A. Franklin, Andres Metspalu, Holly J. Wolf, Jesper Holst Pedersen, André G. Uitterlinden, Haseem Ashraf, Gregory T. Jones, Nicole Soranzo, Barbara Nitz, Thorgeir E. Thorgeirsson, Ben A. Oostra, John R. Thompson, Mari Nelis, Jeffrey R. Gulcher, Dan Rujescu, Angela Döring, Jes S. Lindholt, Henning Tiemeier, Ina Giegling, Grant W. Montgomery, Anneli Pouta, Benjamin Dieplinger, Solveig Gretarsdottir, Michele L. Pergadia, Stefan E Matthiasson, Veronica De Diego, Tõnu Esko
Publikováno v:
Thorgeirsson, T E, Gudbjartsson, D F, Surakka, I, Vink, J M, Amin, N, Geller, F, Sulem, P, Rafnar, T, Esko, T, Walter, S, Gieger, C, Rawal, R, Mangino, M, Prokopenko, I, Magi, R, Keskitalo, K, Gudjonsdottir, I H, Gretarsdottir, S, Stefansson, H, Thompson, J R, Aulchenko, Y S, Nelis, M, Aben, K K, Heijer, M, Dirksen, A, Ashraf, H, Soranzo, N, Valdes, A M, Steves, C, Uitterlinden, A G, Hofman, A, Tonjes, A, Kovacs, P, Hottenga, J J, Willemsen, G, Vogelzangs, N, Doring, A, Dahmen, N, Nitz, B, Pergadia, M L, Saez, B, De Diego, V, Lezcano, V, Garcia-Prats, M D, Ripatti, S, Perola, M, Kettunen, J, Hartikainen, A L, Pouta, A, Laitinen, J, Isohanni, M, Huei-Yi, S, Allen, M, Krestyaninova, M, Hall, A S, Jones, G T, van Rij, A M, Mueller, T, Dieplinger, B, Haltmayer, M, Jonsson, S, Matthiasson, S E, Oskarsson, H, Tyrfingsson, T, Kiemeney, L A, Mayordomo, J I, Lindholt, J S, Pedersen, J H, Franklin, W A, de Wolf, H, Montgomery, GW, Heath, A C, Martin, N G, Madden, P A F, Giegling, I, Rujescu, D, Jarvelin, M R, Salomaa, V, Stumvoll, M, Spector, T D, Wichmann, H E, Metspalu, A, Samani, N J, Penninx, B W J H, Oostra, B A, Boomsma, D I, Tiemeier, H, van Duijn, C M, Kaprio, J, Gulcher, J R, McCarthy, M I, Peltonen, L, Thorsteinsdottir, U & Stefansson, K 2010, ' Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior ', Nature Genetics, vol. 42, no. 5, pp. 448-453 . https://doi.org/10.1038/ng.573
Nature Genetics, 42(5), 448-453. Nature Publishing Group
Thorgeirsson, T E, Gudbjartsson, D F, Surakka, I, Vink, J M, Amin, N, Geller, F, Sulem, P, Rafnar, T, Esko, T, Walter, S, Gieger, C, Rawal, R, Mangino, M, Prokopenko, I, Mägi, R, Keskitalo, K, Gudjonsdottir, I H, Gretarsdottir, S, Stefansson, H, Thompson, J R, Aulchenko, Y S, Nelis, M, Aben, K K, den Heijer, M, Dirksen, A, Ashraf, H, Soranzo, N, Valdes, A M, Steves, C, Uitterlinden, A G, Hofman, A, Tönjes, A, Kovacs, P, Hottenga, J J, Willemsen, G, Vogelzangs, N, Döring, A, Dahmen, N, Nitz, B, Pergadia, M L, Saez, B, De Diego, V, Lezcano, V, Garcia-Prats, M D, Ripatti, S, Perola, M, Kettunen, J, Hartikainen, A-L, Pouta, A, Lindholt, J S & ENGAGE Consortium 2010, ' Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior ', Nature Genetics, vol. 42, no. 5, pp. 448-53 . https://doi.org/10.1038/ng.573
Nature Genetics; Vol 42
Nature Genetics, 42(5), 448-U135. Nature Publishing Group
Nature Genetics, 42, 5, pp. 448-53
Nature Genetics
Nature Genetics, 42, 448-53
Nature Genetics, 42(5), 448
Nature Genetics, 42(5), 448-453. Nature Publishing Group
Thorgeirsson, T E, Gudbjartsson, D F, Surakka, I, Vink, J M, Amin, N, Geller, F, Sulem, P, Rafnar, T, Esko, T, Walter, S, Gieger, C, Rawal, R, Mangino, M, Prokopenko, I, Mägi, R, Keskitalo, K, Gudjonsdottir, I H, Gretarsdottir, S, Stefansson, H, Thompson, J R, Aulchenko, Y S, Nelis, M, Aben, K K, den Heijer, M, Dirksen, A, Ashraf, H, Soranzo, N, Valdes, A M, Steves, C, Uitterlinden, A G, Hofman, A, Tönjes, A, Kovacs, P, Hottenga, J J, Willemsen, G, Vogelzangs, N, Döring, A, Dahmen, N, Nitz, B, Pergadia, M L, Saez, B, De Diego, V, Lezcano, V, Garcia-Prats, M D, Ripatti, S, Perola, M, Kettunen, J, Hartikainen, A-L, Pouta, A, Lindholt, J S & ENGAGE Consortium 2010, ' Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior ', Nature Genetics, vol. 42, no. 5, pp. 448-53 . https://doi.org/10.1038/ng.573
Nature Genetics; Vol 42
Nature Genetics, 42(5), 448-U135. Nature Publishing Group
Nature Genetics, 42, 5, pp. 448-53
Nature Genetics
Nature Genetics, 42, 448-53
Nature Genetics, 42(5), 448
Contains fulltext : 89305.pdf (Publisher’s version ) (Closed access) Smoking is a common risk factor for many diseases. We conducted genome-wide association meta-analyses for the number of cigarettes smoked per day (CPD) in smokers (n = 31,266) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b690f9ac3202429b59597d691f2678a4
https://research.vu.nl/en/publications/cae67b61-8a02-457b-81de-b25c4e9a2f90
https://research.vu.nl/en/publications/cae67b61-8a02-457b-81de-b25c4e9a2f90
Autor:
Emiko Noguchi, Jon Tinsley, Mark Edwards, Stephan K. Weiland, Nicholas J. Dickens, Chris P. Ponting, John Broxholme, Crystal Baker, Peter J. Barnes, Luzheng Xue, Gonçalo R. Abecasis, Miriam F. Moffatt, Alisoun H. Carey, William O.C.M. Cookson, Elizabeth C. Townsend, Ian M. Adcock, E. Yvonne Jones, Youming Zhang, G. Mark Lathrop, Rosie Nicholls, Claire Dimon, Erika von Mutius, Maxine Allen, Richard Holt, Michael Kabesch, Helene Jones, Sumit Bhattacharyya, Andrea Heinzmann, Nicholas Lench, David Carr
Publikováno v:
NATURE GENETICS. 35(3)
Asthma is a common disease in children and young adults. Four separate reports have linked asthma and related phenotypes to an ill-defined interval between 2q14 and 2q32 (refs. 1-4), and two mouse genome screens have linked bronchial hyper-responsive