New melanocortin-like peptide of E. coli can suppress inflammation via the mammalian melanocortin-1 receptor (MC1R): possible endocrine-like function for microbes of the gut

Autor: Gary J. Schwartz, Kanta Ochani, Anthony S. Liotta, Jesse Roth, Shervin Rabizadeh, Haichao Wang, Mahendar Ochani, Joanne Gutierrez, Christian Maaser, Mark Donowitz, Syed F. Mehdi, Derek LeRoith, Aviva Rabin, Maxine A. Lesniak, Christopher J. Czura, Joseph Shiloach, Mark Westlake, Markus Böhm, Kevin J. Tracey, Ann Danoff, Aida Zarfeshani, Klaus Kannengiesser, Xiaoling Qiang, Suparna Sanyal, Huan Yang, Xueliang Ge

Publikováno v: npj Biofilms and Microbiomes, Vol 3, Iss 1, Pp 1-11 (2017)

E. coli releases a 33 amino acid peptide melanocortin-like peptide of E. coli (MECO-1) that is identical to the C-terminus of the E. coli elongation factor-G (EF-G) and has interesting similarities to two prominent mammalian melanocortin hormones, al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1d4dcb4896f7e1cccbfdc33aa9ce8b8
http://link.springer.com/article/10.1038/s41522-017-0039-9

Insulin and Growth Hormone: Interactions with Specific Receptors on the Cell Surface

Autor: Jesse Roth, Maxine A. Lesniak

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f0e889e6e9a16dac925f17cf5c43e25c
https://doi.org/10.1159/000392949

Insulin and insulin-like growth factor I action in the chick embryo: From biology to molecular endocrinology

Autor: Maxine A. Lesniak, Matias Girbau, J Alemany, Jose Serrano, Louis Scavo, Flora de Pablo

Publikováno v: Journal of Experimental Zoology. 256:187-191

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ace7658bfabe8f87b35288fd722adf65
https://doi.org/10.1002/jez.1402560440

Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia

Autor: Ryo Suzuki, Yoshiharu Tsubamoto, Salvatore Sciacchitano, Yasuo Akanuma, Hisahiko Sekihara, Shinichi Aizawa, Yasuo Terauchi, Ryozo Nagai, Shinobu Satoh, Simeon I. Taylor, Toshimasa Yamauchi, Naoto Kubota, Kajuro Komeda, Ryosuke Nakano, Kazuhiro Eto, Maxine A. Lesniak, Kazuyuki Tobe, Takashi Kadowaki, Satoshi Kimura, Hiroshi Miki

Publikováno v: Diabetes (N.Y.N.Y.) 49 (2000): 1880–1889.
info:cnr-pdr/source/autori:Kubota N., Tobe K., Terauchi Y., Eto K., Yamauchi T., Suzuki R., Tsubamoto Y., Komeda K., Nakano R., Miki H., Satoh S., Sekihara H., Sciacchitano S., Lesniak M., Aizawa S., Nagai R., Kimura S., Akanuma Y., Taylor S.I., Kadowaki T./titolo:Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia./doi:/rivista:Diabetes (N.Y.N.Y.)/anno:2000/pagina_da:1880/pagina_a:1889/intervallo_pagine:1880–1889/volume:49

To investigate the role of insulin receptor substrate (IRS)-2 in vivo, we generated IRS-2-deficient mice by gene targeting. Although homozygous IRS-2-deficient mice (IRS-2-/- mice) had a body weight similar to wild-type mice, they progressively devel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::707f9c20dabbafdf5b4314c980233c59
http://www.cnr.it/prodotto/i/4386

Variant sequences of insulin receptor substrate-1 in patients with noninsulin-dependent diabetes mellitus

Autor: Yoshifumi Suzuki, R. Lauro, R D'Alfonso, Simeon I. Taylor, Giorgio Sesti, Maxine A. Lesniak, A Bertoli, Yumi Imai, Domenico Accili, A Fusco

Publikováno v: Scopus-Elsevier

The pathophysiology of noninsulin-dependent diabetes mellitus (NIDDM) is characterized by insulin resistance and insulin deficiency. To search for genetic defects causing NIDDM, we have screened for mutations in the gene encoding insulin receptor sub

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14b4c8772788eb55e59a0a9ceebd2748
http://hdl.handle.net/2108/50685