Fragment merging strategies with known pyrimidine scaffolds targeting dihydrofolate reductase from Mycobacterium tuberculosis

Autor: Tim Kirkman, Suk Fun Tan, Sair Maximo Chavez Pacheco, Alexander Hammer, Manuela Tosin, Anthony Coyne, Marcio Dias

Publikováno v: ChemMedChem.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::07205df6190cd3bd116440792cbded7f
https://doi.org/10.1002/cmdc.202300240

Using a Fragment-Based Approach to Identify Alternative Chemical Scaffolds Targeting Dihydrofolate Reductase from Mycobacterium tuberculosis

Autor: Petros A. Tyrakis, Marcio Vinicius Bertacine Dias, J.A. Ribeiro, Maurício L. Sforça, Silvana A. Rocco, Tom L. Blundell, Anthony G. Coyne, Roberto Parise-Filho, Gabriel S. de Oliveira, Sair Maximo Chavez-Pacheco, Timothy Kirkman, Chris Abell, Alexander Hammer, Jamal El Bakali, G.A. Libreros-Zuniga

Publikováno v: Web of Science
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Made available in DSpace on 2020-12-10T20:10:10Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-08-14 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Bill & Melinda Gates Foundation Conselho Nacional de Desenvolvimento Cient�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adefd9fb33513d13efa66f3cced5b24e
https://doi.org/10.1021/acsinfecdis.0c00263

Using a fragment-based approach to identify novel chemical scaffolds targeting the dihydrofolate reductase (DHFR) from Mycobacterium tuberculosis

Autor: Timothy Kirkman, Chris Abell, Sair Maximo Chavez-Pacheco, Tom L. Blundell, Silvana A. Rocco, Anthony G. Coyne, Petros A. Tyrakis, J.A. Ribeiro, Gerardo Andrés Libreros Zúñiga, Maurício L. Sforça, Alexander Hammer, Roberto Parise-Filho, Jamal El Bakali, Marcio Vinicius Bertacine Dias, Gabriel S. de Oliveira

Dihydrofolate reductase (DHFR), a key enzyme involved in folate metabolism, is a widely explored target in the treatment of cancer, immune diseases, bacteria and protozoa infections. Although several antifolates have proved successful in the treatmen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ff6acff8ed14e9e2e3b04f257bba2f2
https://doi.org/10.1101/2020.03.30.016204

Cloning, expression, purification and biophysical analysis of two putative halogenases from the glycopeptide A47,934 gene cluster of Streptomyces toyocaensis

Autor: Tabata P. Cardoso, Priscila dos Santos Bury, Sair Maximo Chavez-Pacheco, Larissa Antelo de Sá, Marcio Vinicius Bertacine Dias

Publikováno v: Web of Science
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Made available in DSpace on 2018-11-26T17:31:24Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-04-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Gly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f56e0a137923c4ed2cff414686b71c2
https://doi.org/10.1016/j.pep.2017.01.001

Work in Progress: Design and implementation of a didactic module with manual interface, PLC interface and PC serial interface for teaching process control techniques

Autor: Jose Guillermo Maximo Chavez, Lucia Carolina Eliana Cuellar Diaz

Publikováno v: 2019 IEEE World Conference on Engineering Education (EDUNINE).

This paper presents the design and implementation of a didactic module for teaching process control techniques for electronics engineering students. The module is designed to teach the students how to control the flow and level of a process using dif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::182b7a595aaf22f79c285b755a56a58e
https://doi.org/10.1109/edunine.2019.8875832