Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Maximillian Hafer"'
Publikováno v:
Platelets, Vol 32, Iss 6, Pp 770-778 (2021)
Thrombopoietin (TPO) and its receptor, MPL, are the primary regulators of platelet production and critical for hematopoietic stem cell (HSC) maintenance. Since TPO was first cloned in 1994, the physiological and pathological roles of TPO and MPL have
Externí odkaz:
https://doaj.org/article/8a3d80fe6cdf48ee8e383d79b524fbb5
Autor:
Stephan Wilmes, Polly-Anne Jeffrey, Jonathan Martinez-Fabregas, Maximillian Hafer, Paul K Fyfe, Elizabeth Pohler, Silvia Gaggero, Martín López-García, Grant Lythe, Charles Taylor, Thomas Guerrier, David Launay, Suman Mitra, Jacob Piehler, Carmen Molina-París, Ignacio Moraga
Publikováno v:
eLife, Vol 10 (2021)
Cytokines elicit pleiotropic and non-redundant activities despite strong overlap in their usage of receptors, JAKs and STATs molecules. We use IL-6 and IL-27 to ask how two cytokines activating the same signaling pathway have different biological rol
Externí odkaz:
https://doaj.org/article/036f2f9b6d674d24920c5291fa65c2f9
Autor:
Jonathan Martinez-Fabregas, Stephan Wilmes, Luopin Wang, Maximillian Hafer, Elizabeth Pohler, Juliane Lokau, Christoph Garbers, Adeline Cozzani, Paul K Fyfe, Jacob Piehler, Majid Kazemian, Suman Mitra, Ignacio Moraga
Publikováno v:
eLife, Vol 8 (2019)
Cytokines activate signaling via assembly of cell surface receptors, but it is unclear whether modulation of cytokine-receptor binding parameters can modify biological outcomes. We have engineered IL-6 variants with different affinities to gp130 to i
Externí odkaz:
https://doaj.org/article/1b051ad15afd4701b89407a5956a40df
Autor:
Alexandra Tsirigotaki, Ann Dansercoer, Koen H.G. Verschueren, Iva Marković, Christoph Pollmann, Maximillian Hafer, Jan Felix, Catherine Birck, Wouter Van Putte, Dominiek Catteeuw, Jan Tavernier, J. Fernando Bazan, Jacob Piehler, Savvas N. Savvides, Kenneth Verstraete
Publikováno v:
Nature Structural & Molecular Biology. 30:551-563
The adipokine Leptin activates its type I cytokine receptor (LEP-R) in the hypothalamus to regulate body weight and exerts additional pleiotropic functions in immunity, fertility, and cancer. However, the structure and mechanism of Leptin-mediated LE
Autor:
Steven C, Wilson, Nathanael A, Caveney, Michelle, Yen, Christoph, Pollmann, Xinyu, Xiang, Kevin M, Jude, Maximillian, Hafer, Naotaka, Tsutsumi, Jacob, Piehler, K Christopher, Garcia
Publikováno v:
Nature. 609(7927)
The IL-17 family of cytokines and receptors have central roles in host defence against infection and development of inflammatory diseases
Autor:
Elizabeth Pohler, Ignacio Moraga, Suman Mitra, Martín López-García, Jacob Piehler, Grant Lythe, Stephan Wilmes, Silvia Gaggero, Charles Taylor, Polly-Anne Jeffrey, Jonathan Martinez-Fabregas, Carmen Molina-París, Maximillian Hafer, T. Guerrier, David Launay, Paul K. Fyfe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a345388a0ce6d98b032f01ba82ca9a3
https://doi.org/10.7554/elife.66014.sa2
https://doi.org/10.7554/elife.66014.sa2
Autor:
Silvia Gaggero, David Launay, Jacob Piehler, Polly-Anne Jeffrey, Stephan Wilmes, Grant Lythe, Ignacio Moraga, Jonathan Martinez-Fabregas, Charles Taylor, Suman Mitra, Martín López-García, Elizabeth Pohler, Maximillian Hafer, T. Guerrier, Carmen Molina-París, Paul K. Fyfe
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
Cytokines elicit pleiotropic and non-redundant activities despite strong overlap in their usage of receptors, JAKs and STATs molecules. We use IL-6 and IL-27 to ask how two cytokines activating the same signaling pathway have different biological rol
Autor:
Maximillian Hafer, T. Guerrier, Paul K. Fyfe, David Launay, Carmen Molina-París, Polly-Anne Jeffrey, Stephan Wilmes, Elizabeth Pohler, Grant Lythe, Martín López-García, Jonathan Martinez-Fabregas, Mitra Suman, Jacob Piehler, Ignacio Moraga, Silvia Gaggero
Cytokines elicit pleiotropic and non-redundant activities despite strong overlap in their usage of receptors, JAKs and STATs molecules. We use IL-6 and IL-27 to ask how two cytokines activating the same signaling pathway have different biological rol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f5c1c8cfd65bc7f0733b6275d7f5a52
https://doi.org/10.1101/2021.01.08.425379
https://doi.org/10.1101/2021.01.08.425379
Autor:
Ilpo Vattulainen, Julie A. Tucker, Stephan Wilmes, Ian S. Hitchcock, Tess A. Stanly, Joni Vuorio, Katiuska Pulgar Prieto, Sara Löchte, K. Christopher Garcia, Stevan R. Hubbard, Vivek Sharma, Jacob Piehler, Hauke Winkelmann, Chetan Poojari, Christian Richter, Maximillian Hafer, Rainer Kurre, Ignacio Moraga
Publikováno v:
Science
Activated by interaction Cytokines trigger immune responses when they bind to their cognate receptors. Class I cytokine receptors rely on the associated Janus kinase 2 (JAK2) to initiate signal transduction. There has been debate over whether activat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38943a502828c3013c7d23033a37568c
https://europepmc.org/articles/PMC8117407/
https://europepmc.org/articles/PMC8117407/
Autor:
Christoph Garbers, Luopin Wang, Jonathan Martinez-Fabregas, Juliane Lokau, Paul K. Fyfe, Elizabeth Pohler, Jacob Piehler, Adeline Cozzani, Majid Kazemian, Stephan Wilmes, Suman Mitra, Maximillian Hafer, Ignacio Moraga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25e703e84b1190a6ef3b07cb5d396272
https://doi.org/10.7554/elife.49314.sa2
https://doi.org/10.7554/elife.49314.sa2