Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Maximillian A. Rogers"'
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
Externí odkaz:
https://doaj.org/article/43199e78c0524a5bb67351e54ce74486
Autor:
Maximillian A. Rogers, Samantha K. Atkins, Kang H. Zheng, Sasha A. Singh, Sarvesh Chelvanambi, Tan H. Pham, Shiori Kuraoka, Erik S. G. Stroes, Masanori Aikawa, Elena Aikawa
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Lipoprotein(a) (Lp[a]) blood levels >50 mg/dL is a major cardiovascular disease risk factor in humans. Lp(a) associates with increased cardiovascular calcification, a critical pathology with no clinically available drug therapies. The mechanisms thro
Externí odkaz:
https://doaj.org/article/a63d7c1e04bd4154820fe79dd6cd8b0f
Autor:
Shinji Goto, Maximillian A. Rogers, Mark C. Blaser, Hideyuki Higashi, Lang H. Lee, Florian Schlotter, Simon C. Body, Masanori Aikawa, Sasha A. Singh, Elena Aikawa
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 6 (2019)
Aortic valvular interstitial cells (VICs) isolated from patients undergoing valve replacement are commonly used as in vitro models of calcific aortic valve disease (CAVD). Standardization of VIC calcification, however, has not been implemented, which
Externí odkaz:
https://doaj.org/article/8d0ebe2ba483434c829b424833e89d23
Autor:
Yoshio Yamauchi, Maximillian A. Rogers
Publikováno v:
Frontiers in Endocrinology, Vol 9 (2018)
Cholesterol is a vital lipid molecule for mammalian cells, regulating fluidity of biological membranes, and serving as an essential constituent of lipid rafts. Mammalian cells acquire cholesterol from extracellular lipoproteins and from de novo synth
Externí odkaz:
https://doaj.org/article/e9dbbef0796d4d4ea63975dcc845d536
Autor:
Farwah Iqbal, Florian Schlotter, Dakota Becker-Greene, Adrien Lupieri, Claudia Goettsch, Joshua D Hutcheson, Maximillian A Rogers, Shinsuke Itoh, Arda Halu, Lang Ho Lee, Mark C Blaser, Andrew K Mlynarchik, Sumihiko Hagita, Shiori Kuraoka, Hao Yu Chen, James C Engert, Livia S A Passos, Prabhash K Jha, Eric A Osborn, Farouc A Jaffer, Simon C Body, Simon C Robson, George Thanassoulis, Masanori Aikawa, Sasha A Singh, Abhijeet R Sonawane, Elena Aikawa
Publikováno v:
European Heart Journal. 44:885-898
AimsCalcific aortic valve disease (CAVD) is the most common valve disease, which consists of a chronic interplay of inflammation, fibrosis, and calcification. In this study, sortilin (SORT1) was identified as a novel key player in the pathophysiology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17619affe70613293bf816312001402b
https://doi.org/10.1093/eurheartj/ehac818
https://doi.org/10.1093/eurheartj/ehac818
Autor:
Shunsuke Katsuki, Prabhash K. Jha, Adrien Lupieri, Toshiaki Nakano, Livia S.A. Passos, Maximillian A. Rogers, Dakota Becker-Greene, Thanh-Dat Le, Julius L. Decano, Lang Ho Lee, Gabriel C. Guimaraes, Ilyes Abdelhamid, Arda Halu, Alessandro Muscoloni, Carlo V. Cannistraci, Hideyuki Higashi, Hengmin Zhang, Amélie Vromman, Peter Libby, C. Keith Ozaki, Amitabh Sharma, Sasha A. Singh, Elena Aikawa, Masanori Aikawa
Publikováno v:
Circulation research. 131(11)
Background: Activated macrophages contribute to the pathogenesis of vascular disease. Vein graft failure is a major clinical problem with limited therapeutic options. PCSK9 (proprotein convertase subtilisin/kexin 9) increases low-density lipoprotein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1cce54f1f5552a4816c5ad29b1b44d5
https://pubmed.ncbi.nlm.nih.gov/36263780
https://pubmed.ncbi.nlm.nih.gov/36263780
Autor:
Maximillian A. Rogers, Catherine C. Y. Chang, Robert A. Maue, Elaina M. Melton, Andrew A. Peden, William S. Garver, Junghoon Lee, Peter Schroen, Mitchell Huang, Ta-Yuan Chang
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Significance Niemann-Pick type C disease (NPCD) is an incurable genetic neurological disorder. Cells with NPC mutations fail to export cholesterol from endosomal organelle to multiple other organelles. ACAT1 is an enzyme that converts cholesterol to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a817a781ec7473dfbd6a89ca2b7e952a
https://doi.org/10.1073/pnas.2201646119
https://doi.org/10.1073/pnas.2201646119
Autor:
Elena Aikawa, Maximillian A. Rogers
Publikováno v:
Eur Heart J
The morbidity and mortality rates of calcific aortic valve disease (CAVD) remain high while treatment options are limited. Here, we evaluated the role and therapeutic value of dual-specificity phosphatase 26 (DUSP26) in CAVD.Microarray profiling of h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85ba94b51ade3a3b83354c44e5f99c7e
https://doi.org/10.1093/eurheartj/ehab381
https://doi.org/10.1093/eurheartj/ehab381
Autor:
Shriram Nallamshetty, Jorge Plutzky, Jiaohua Chen, Masanori Aikawa, Peter Libby, Shinji Goto, Elena Aikawa, Jochen D. Muehlschlegel, Maximillian A. Rogers, Tan Pham
Publikováno v:
Arterioscler Thromb Vasc Biol
Objective: Retinoic acid (RA) is a ligand for nuclear receptors that modulate gene transcription and cell differentiation. Whether RA controls ectopic calcification in humans is unknown. We tested the hypothesis that RA regulates osteogenic different
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d30453a27b2b5d21a955827217314999
https://doi.org/10.1161/atvbaha.119.313366
https://doi.org/10.1161/atvbaha.119.313366
Autor:
Takehito Okui, Masaya Iwashita, Maximillian A Rogers, Shiori Kuraoka, Arda Halu, Yoshikazu Sawada, Masanori Aikawa, Sasha A Singh, Elena Aikawa
Publikováno v:
Circulation. 144
Background: Cardiovascular calcification is a critical pathology associated with increased cardiovascular risk, but there are no FDA-approved anti-calcification therapies. Through an unbiased screening approach, we previously identified carnitine O-o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d5a6b5b3d8dbc063d235ba525d8e376
https://doi.org/10.1161/circ.144.suppl_1.12316
https://doi.org/10.1161/circ.144.suppl_1.12316