Egg-laying and locomotory screens with C. elegans yield a nematode-selective small molecule stimulator of neurotransmitter release

Autor: Sean Harrington, Jessica J. Knox, Andrew R. Burns, Ken-Loon Choo, Aaron Au, Megan Kitner, Cecile Haeberli, Jacob Pyche, Cassandra D’Amata, Yong-Hyun Kim, Jonathan R. Volpatti, Maximillano Guiliani, Jamie Snider, Victoria Wong, Bruna M. Palmeira, Elizabeth M. Redman, Aditya S. Vaidya, John S. Gilleard, Igor Stagljar, Sean R. Cutler, Daniel Kulke, James J. Dowling, Christopher M. Yip, Jennifer Keiser, Inga Zasada, Mark Lautens, Peter J. Roy

Publikováno v: Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)

A C. elegans-based screening approach identifies nementin as a nematode-selective nematicide that can be used synergistically with acetylcholinesterase inhibitors

Externí odkaz: https://doaj.org/article/b2ae40e60cd44727b137593ac69b190f

Egg-laying and locomotory screens with C. elegans yield a nematode-selective small molecule stimulator of neurotransmitter release.

Autor: Harrington, Sean^1,2 (AUTHOR), Knox, Jessica J.^2,3 (AUTHOR), Burns, Andrew R.^2,3 (AUTHOR), Choo, Ken-Loon⁴ (AUTHOR), Au, Aaron^2,5 (AUTHOR), Kitner, Megan⁶ (AUTHOR), Haeberli, Cecile^7,8 (AUTHOR), Pyche, Jacob^1,2 (AUTHOR), D'Amata, Cassandra² (AUTHOR), Kim, Yong-Hyun⁴ (AUTHOR), Volpatti, Jonathan R.^9,10 (AUTHOR), Guiliani, Maximillano^2,5 (AUTHOR), Snider, Jamie² (AUTHOR), Wong, Victoria² (AUTHOR), Palmeira, Bruna M.¹¹ (AUTHOR), Redman, Elizabeth M.¹¹ (AUTHOR), Vaidya, Aditya S.^12,13 (AUTHOR), Gilleard, John S.¹¹ (AUTHOR), Stagljar, Igor^2,3,14,15,16 (AUTHOR), Cutler, Sean R.^12,13 (AUTHOR)

Publikováno v: Communications Biology. 8/24/2022, Vol. 5 Issue 1, p1-14. 14p.