Super-enhancer hijacking drives ectopic expression of hedgehog pathway ligands in meningiomas

Autor: Mark W. Youngblood, Zeynep Erson-Omay, Chang Li, Hinda Najem, Süleyman Coșkun, Evgeniya Tyrtova, Julio D. Montejo, Danielle F. Miyagishima, Tanyeri Barak, Sayoko Nishimura, Akdes Serin Harmancı, Victoria E. Clark, Daniel Duran, Anita Huttner, Timuçin Avşar, Yasar Bayri, Johannes Schramm, Julien Boetto, Matthieu Peyre, Maximilien Riche, Roland Goldbrunner, Nduka Amankulor, Angeliki Louvi, Kaya Bilgüvar, M. Necmettin Pamir, Koray Özduman, Türker Kilic, James R. Knight, Matthias Simon, Craig Horbinski, Michel Kalamarides, Marco Timmer, Amy B. Heimberger, Ketu Mishra-Gorur, Jennifer Moliterno, Katsuhito Yasuno, Murat Günel

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)

Abstract Hedgehog signaling mediates embryologic development of the central nervous system and other tissues and is frequently hijacked by neoplasia to facilitate uncontrolled cellular proliferation. Meningiomas, the most common primary brain tumor,

Externí odkaz: https://doaj.org/article/32c53254d0434114aadc0376769d30b2

Severity, timeline, and management of complications after stereotactic brain biopsy

Autor: Bertrand Mathon, Franck Bielle, Chung-Hi Do, Ahmed Idbaih, Vincent Degos, Eimad Shotar, Mehdi Touat, Karima Mokhtari, R. Pasqualotto, Aymeric Amelot, Alexandre Carpentier, Marc Pineton de Chambrun, Mamadou Deme, Lydia Chougar, Alexandre Le Joncour, Pauline Marijon, Alice Jacquens, Maximilien Riche

Publikováno v: Journal of Neurosurgery. 136:867-876

OBJECTIVE The literature shows discrepancies in stereotactic brain biopsy complication rates, severities, and outcomes. Little is known about the timeline of postbiopsy complications. This study aimed to analyze 1) complications following brain biops

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b4a468a37d0f447452edf42b23044c8
https://doi.org/10.3171/2021.3.jns21134

Efficacy of a Second Brain Biopsy for Intracranial Lesions after Initial Negativity

Autor: Mohamed Chabaane, Maximilien Riche, Alexandre Carpentier, Karima Mokhtari, Franck Bielle, Bertrand Mathon, Aymeric Amelot, Mehdi Touat

Publikováno v: Journal of Clinical Neurology (Seoul, Korea)
Journal of Clinical Neurology
Journal of Clinical Neurology, 2020, 16 (4), pp.659. ⟨10.3988/jcn.2020.16.4.659⟩
Journal of Clinical Neurology, Korean Neurological Association, 2020, 16 (4), pp.659. ⟨10.3988/jcn.2020.16.4.659⟩

International audience; Background and purpose: The rationale for performing a second brain biopsy after initial negativity is not well evaluated in the literature. This study was designed to 1) assess the efficacy of a second brain biopsy when the f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bf4be9fb32ac53be998dab0d7e564b1
http://europepmc.org/articles/PMC7542000

Pilot Study of Repeated Blood-Brain Barrier Disruption in Patients with Mild Alzheimer's Disease with an Implantable Ultrasound Device

Autor: Bruno Dubois, Alexandre Carpentier, Dawn Matthews, Stéphane Epelbaum, Benoît Delatour, Ninon Burgos, Lisa Belin, Marcel Levy, Mathieu Santin, Maximilien Riche, Michael Canney, Cyril Martin, M.-O. Habert, Marion Houot, Aicha Bah, Carole Desseaux, Guillaume Bouchoux, Karine Martin, Sébastian Ströer

Publikováno v: Alzheimer's Research and Therapy
Alzheimer's Research and Therapy, 2022, 14 (40), ⟨10.1186/s13195-022-00981-1⟩

Background Temporary disruption of the blood-brain barrier (BBB) using pulsed ultrasound leads to the clearance of both amyloid and tau from the brain, increased neurogenesis, and mitigation of cognitive decline in pre-clinical models of Alzheimer’

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e43b983d6fd7c6e0b2ef898d00e4d437
https://hal.inria.fr/hal-03484130

Antimicrobial prophylaxis in noninstrumented spine surgery: a prospective study to determine efficacy and drawbacks

Autor: Alexandre Carpentier, Maximilien Riche, Aymeric Amelot, Anne-Marie Korinek, Bertrand Mathon, Vincent Degos, S. Latreille

Publikováno v: Journal of neurosurgery. Spine.

OBJECTIVE The authors sought to evaluate the roles of perioperative antibiotic prophylaxis in noninstrumented spine surgery (NISS), both in postoperative infections and the impact on the selection of resistant bacteria. To the authors’ knowledge, o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb28e2a99d176b80ac1be9810d7e1a27
https://pubmed.ncbi.nlm.nih.gov/34243156