Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Maximiliano Vásquez"'
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTWith the growing significance of antibodies as a therapeutic class, identifying developability risks early during development is of paramount importance. Several high-throughput in vitro assays and in silico approaches have been proposed to d
Externí odkaz:
https://doaj.org/article/a8802dab5885417d8e02ba81e604f042
Publikováno v:
Antibodies, Vol 12, Iss 3, p 54 (2023)
Therapeutic antibodies represent the most significant modality in biologics, with around 150 approved drugs on the market. In addition to specific target binding mediated by the variable fragments (Fvs) of the heavy and light chains, antibodies posse
Externí odkaz:
https://doaj.org/article/88e7dc5c418f4819ba70208472531bf6
Autor:
Leon F. Willis, Amit Kumar, Tushar Jain, Isabelle Caffry, Yingda Xu, Sheena E. Radford, Nikil Kapur, Maximiliano Vásquez, David J. Brockwell
Publikováno v:
Engineering Reports, Vol 2, Iss 5, Pp n/a-n/a (2020)
Abstract The development of therapeutic monoclonal antibodies (mAbs) can be hindered by their tendency to aggregate throughout their lifetime, which can illicit immunogenic responses and render mAb manufacturing unfeasible. Consequently, there is a n
Externí odkaz:
https://doaj.org/article/0794a7674f0f47228bea193cef914dcc
Autor:
Michael E Brown, Daniel Bedinger, Asparouh Lilov, Palaniswami Rathanaswami, Maximiliano Vásquez, Stéphanie Durand, Ian Wallace-Moyer, Lihui Zhong, Juergen H Nett, Irina Burnina, Isabelle Caffry, Heather Lynaugh, Melanie Sinclair, Tingwan Sun, John Bukowski, Yingda Xu, Yasmina Noubia Abdiche
Publikováno v:
PLoS ONE, Vol 15, Iss 3, p e0229206 (2020)
Here we describe an industry-wide collaboration aimed at assessing the binding properties of a comprehensive panel of monoclonal antibodies (mAbs) against programmed cell death protein 1 (PD-1), an important checkpoint protein in cancer immunotherapy
Externí odkaz:
https://doaj.org/article/fc8fd2aadbea4beb830fe69ba9587bcc
Autor:
Pete Schmidt, Kristin Narayan, Yong Li, Chengzi I. Kaku, Michael E. Brown, Elizabeth Champney, James C. Geoghegan, Maximiliano Vásquez, Eric M. Krauland, Thomas Yockachonis, Shuangyi Bai, Bronwyn M. Gunn, Anthony Cammarata, Christopher M. Rubino, Paul Ambrose, Laura M. Walker
Publikováno v:
Science Translational Medicine. 15
Multiple studies of vaccinated and convalescent cohorts have demonstrated that serum neutralizing antibody (nAb) titers correlate with protection against coronavirus disease 2019 (COVID-19). However, the induction of multiple layers of immunity after
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b87a929ceba729ff3942f02dbc8a1fb
https://doi.org/10.1126/scitranslmed.adg2783
https://doi.org/10.1126/scitranslmed.adg2783
Autor:
Pete Schmidt, Kristin Narayan, Yong Li, Chengzi I. Kaku, Michael E. Brown, Elizabeth Champney, James C. Geoghegan, Maximiliano Vásquez, Eric M. Krauland, Thomas Yockachonis, Shuangyi Bai, Bronwyn M. Gunn, Anthony Cammarata, Christopher M. Rubino, Laura M. Walker
Publikováno v:
medRxiv
Multiple studies of vaccinated and convalescent cohorts have demonstrated that serum neutralizing antibody (nAb) titers correlate with protection against COVID-19. However, the induction of multiple layers of immunity following SARS-CoV-2 exposure ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14b11b2c4bdea6c95499b1a7f867d120
https://europepmc.org/articles/PMC9603828/
https://europepmc.org/articles/PMC9603828/
Autor:
Alida Isidora Díaz Encinas, Carlos Meza Arquiñigo, Eduardo Maximiliano Vásquez Monge, Richard David Berrospi Rosales
Publikováno v:
Investigaciones Sociales. 22:177-193
Al analizar la evolución del desarrollo y los cambios sociales en la población de los distritos de San Mateo de Otao y Callahuanca, Huarochirí 2017, encontramos una serie de transformaciones, principalmente en la agricultura, originalmente de sust
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03b0eda1e05605101c9b533191f3b0ef
https://doi.org/10.15381/is.v22i41.16786
https://doi.org/10.15381/is.v22i41.16786
Autor:
Tushar Jain, Todd Boland, Yingda Xu, Arvind Sivasubramanian, Xiaojun Lu, Kyle A. Barlow, R. Paul Nobrega, Maximiliano Vásquez, Heather Lynaugh
Publikováno v:
mAbs
Contemporary in vivo and in vitro discovery platform technologies greatly increase the odds of identifying high-affinity monoclonal antibodies (mAbs) towards essentially any desired biologically relevant epitope. Lagging discovery throughput is the a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf250fda5734ee78c100d8d69cc76bd9
https://doi.org/10.1080/19420862.2018.1548233
https://doi.org/10.1080/19420862.2018.1548233
Autor:
Isabelle Caffry, Nikil Kapur, Tushar Jain, Yingda Xu, Sheena E. Radford, Maximiliano Vásquez, Leon F. Willis, David J. Brockwell, Amit Kumar
Publikováno v:
Engineering Reports, Vol 2, Iss 5, Pp n/a-n/a (2020)
Engineering Reports
Engineering Reports
The development of therapeutic monoclonal antibodies (mAbs) can be hindered by their tendency to aggregate throughout their lifetime, which can illicit immunogenic responses and render mAb manufacturing unfeasible. Consequently, there is a need to id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8c12edc59a2cc61a90f154ae89a6d2e
https://doi.org/10.1002/eng2.12147
https://doi.org/10.1002/eng2.12147
Autor:
Irina Burnina, Yasmina Noubia Abdiche, Juergen Hermann Nett, Michael Brown, Melanie Sinclair, Yingda Xu, Asparouh Lilov, Isabelle Caffry, Ian Wallace-Moyer, Maximiliano Vásquez, Tingwan Sun, Lihui Zhong, Heather Lynaugh, Palaniswami Rathanaswami, John Bukowski, Stéphanie Durand, Daniel Bedinger
Publikováno v:
PLoS ONE, Vol 15, Iss 3, p e0229206 (2020)
PLoS ONE
PLoS ONE
Here we describe an industry-wide collaboration aimed at assessing the binding properties of a comprehensive panel of monoclonal antibodies (mAbs) against programmed cell death protein 1 (PD-1), an important checkpoint protein in cancer immunotherapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aaf63a42deea692e0f0393ebf753939
https://doaj.org/article/fc8fd2aadbea4beb830fe69ba9587bcc
https://doaj.org/article/fc8fd2aadbea4beb830fe69ba9587bcc