Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Maximiliano Rapanelli"'
Autor:
Maximiliano Rapanelli, Wei Wang, Edward Hurley, Maria Laura Feltri, Christopher Pittenger, Luciana Romina Frick, Zhen Yan
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Loss-of-function mutations of the gene Cul3 have been identified as a risk factor for autism-spectrum disorder (ASD), but the pathogenic mechanisms are not well understood. Conditional Cul3 ablation in cholinergic neurons of mice (ChatCRECul
Externí odkaz:
https://doaj.org/article/2544a3d343e7490ba58fc589a13a3a0f
Autor:
Kantiya Jindachomthong, Chengran Yang, Yuegao Huang, Daniel Coman, Maximiliano Rapanelli, Fahmeed Hyder, Joseph Dougherty, Luciana Frick, Christopher Pittenger
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
IntroductionAn inactivating mutation in the histidine decarboxylase gene (Hdc) has been identified as a rare but high-penetrance genetic cause of Tourette syndrome (TS). TS is a neurodevelopmental syndrome characterized by recurrent motor and vocal t
Externí odkaz:
https://doaj.org/article/b60bdfca7d2f472aac3c5f04aa3ce3f5
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e14713 (2011)
Circuit modification associated with learning and memory involves multiple events, including the addition and remotion of newborn cells trough adulthood. Adult neurogenesis and gliogenesis were mainly described in models of voluntary exercise, enrich
Externí odkaz:
https://doaj.org/article/01c1006f596d45c3b5c9b8c4183a12eb
Publikováno v:
PLoS ONE, Vol 5, Iss 1, p e8656 (2010)
The plasticity in the medial Prefrontal Cortex (mPFC) of rodents or lateral prefrontal cortex in non human primates (lPFC), plays a key role neural circuits involved in learning and memory. Several genes, like brain-derived neurotrophic factor (BDNF)
Externí odkaz:
https://doaj.org/article/7fcd20555ab74ac6aea57f48c9031033
Autor:
Maximiliano Rapanelli, Jamal B. Williams, Kaijie Ma, Fengwei Yang, Ping Zhong, Rajvi Patel, Manasa Kumar, Luye Qin, Benjamin Rein, Zi-Jun Wang, Bibi Kassim, Behnam Javidfar, Lizette Couto, Schahram Akbarian, Zhen Yan
Publikováno v:
Molecular Psychiatry. 27:3355-3366
Large-scale genetic studies have revealed that the most prominent genes disrupted in autism are chromatin regulators mediating histone methylation/demethylation, suggesting the central role of epigenetic dysfunction in this disorder. Here, we show th
Autor:
Susan E. Swedo, Kantiya Jindachomthong, Luciana Romina Frick, Christopher Pittenger, Paul Grant, Kyle Williams, James F. Leckman, Maximiliano Rapanelli
Publikováno v:
Brain, Behavior, and Immunity. 69:304-311
Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcus, or PANDAS, is a syndrome of acute childhood onset of obsessive-compulsive disorder and other neuropsychiatric symptoms in the aftermath of an infection with Group A beta-he
Autor:
Christopher Pittenger, Nobuaki Tamamaki, Kantiya Jindachomthong, Stephanie M. Groman, Luciana Romina Frick, Maximiliano Rapanelli, Meiyu Xu, Jane R. Taylor, Chiyoko Tanahira
Publikováno v:
Biological Psychiatry. 82:194-203
Background Interneuronal pathology is implicated in many neuropsychiatric disorders, including autism spectrum disorder (ASD) and Tourette syndrome (TS). Interneurons of the striatum, including the parvalbumin-expressing fast-spiking interneurons (FS
Publikováno v:
Trends in Neurosciences. 40:397-407
The brain includes multiple types of interconnected excitatory and inhibitory neurons that together allow us to move, think, feel, and interact with the environment. Inhibitory interneurons (INs) comprise a small, heterogeneous fraction, but they exe
Autor:
Xue Wang, Kaijie Ma, Zhen Yan, Wei Wang, Maximiliano Rapanelli, Luye Qin, Jun Qu, Ping Zhong, Luciana Romina Frick, Zi-Jun Wang, Tao Tan
Publikováno v:
Molecular psychiatry. 26(5)
Cullin 3 (Cul3) gene, which encodes a core component of the E3 ubiquitin ligase complex that mediates proteasomal degradation, has been identified as a true high-risk factor for autism. Here, by combining behavioral, electrophysiological, and proteom
Autor:
Maximiliano Rapanelli, Rivka C. Schwarcz, Christopher Pittenger, Kyla D. Horn, Vladimir Pogorelov, Luciana Romina Frick, Angus C. Nairn
Publikováno v:
Journal of Biological Chemistry. 291:21042-21052
The basal ganglia have a central role in motor patterning, habits, motivated behaviors, and cognition as well as in numerous neuropsychiatric disorders. Receptors for histamine, especially the H3 receptor (H3R), are highly expressed in the striatum,