Výsledky vyhledávání - "Maximiliano R, Ferrero"

Akademický článek

Propranolol blocks osteosarcoma cell cycle progression, inhibits angiogenesis and slows xenograft growth in combination with cisplatin-based chemotherapy

Autor: Luisina M. Solernó, Natasha T. Sobol, María F. Gottardo, Carla S. Capobianco, Maximiliano R. Ferrero, Liliana Vásquez, Daniel F. Alonso, Juan Garona

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-18 (2022)

Abstract Osteosarcoma is still associated with limited response to standard-of-care therapy and alarmingly elevated mortality rates, especially in low- and middle-income countries. Despite multiple efforts to repurpose β-blocker propranolol in oncol

Externí odkaz: https://doaj.org/article/76e6670f3c4042928bf7821dcad04983

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Akademický článek

Hallmarks of the relationship between host and Trypanosoma cruzi sulfated glycoconjugates along the course of Chagas disease

Autor: Luciana L. Soprano, Maximiliano R. Ferrero, Thomas Jacobs, Alicia S. Couto, Vilma G. Duschak

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)

American Trypanosomiasis or Chagas disease (ChD), a major problem that is still endemic in large areas of Latin America, is caused by Trypanosoma cruzi. This agent holds a major antigen, cruzipain (Cz). Its C-terminal domain (C-T) is retained in the

Externí odkaz: https://doaj.org/article/7945b6a85ad246b4828a622f5e75c47d

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Akademický článek

Cruzipain Sulfotopes-Specific Antibodies Generate Cardiac Tissue Abnormalities and Favor Trypanosoma cruzi Infection in the BALB/c Mice Model of Experimental Chagas Disease

Autor: Luciana L. Soprano, Maximiliano R. Ferrero, Malena Landoni, Gabriela A. García, Mónica I. Esteva, Alicia S. Couto, Vilma G. Duschak

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 11 (2022)

Trypanosoma cruzi cruzipain (Cz) bears a C-terminal domain (C-T) that contains sulfated epitopes “sulfotopes” (GlcNAc6S) on its unique N-glycosylation site. The effects of in vivo exposure to GlcNAc6S on heart tissue ultrastructure, immune respon

Externí odkaz: https://doaj.org/article/45739db653b84dc99a59139195ffe308

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Propranolol blocks osteosarcoma cell cycle progression, inhibits angiogenesis and slows xenograft growth in combination with cisplatin-based chemotherapy

Autor: Luisina M, Solernó, Natasha T, Sobol, María F, Gottardo, Carla S, Capobianco, Maximiliano R, Ferrero, Liliana, Vásquez, Daniel F, Alonso, Juan, Garona

Publikováno v: Scientific reports. 12(1)

Osteosarcoma is still associated with limited response to standard-of-care therapy and alarmingly elevated mortality rates, especially in low- and middle-income countries. Despite multiple efforts to repurpose β-blocker propranolol in oncology, its

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::460571a05e95643173577b2b456f9f01
https://pubmed.ncbi.nlm.nih.gov/36075937

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An anionic synthetic sugar containing 6-SO3 -NAcGlc mimics the sulfated cruzipain epitope that plays a central role in immune recognition

Autor: Alicia S, Couto, Luciana L, Soprano, Malena, Landoni, Marilyne, Pourcelot, Diana M, Acosta, Laurent, Bultel, Juliana, Parente, Maximiliano R, Ferrero, Maximilien, Barbier, Christophe, Dussouy, Mónica I, Esteva, José, Kovensky, Vilma G, Duschak

Publikováno v: FEBS Journal
FEBS Journal, Wiley, 2012, 279 ((19)), pp.3665-79. ⟨10.1111/j.1742-4658.2012.08728.x⟩
CIC Digital (CICBA)
Comisión de Investigaciones Científicas de la Provincia de Buenos Aires
instacron:CICBA

International audience; Cruzipain (Cz), the major cysteine proteinase of Trypanosoma cruzi, is a glycoprotein that contains sulfated high-mannose-type oligosaccharides. We have previously determined that these sulfate groups are targets of specific i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::e0d97e0bf0e4fccfef0daa33153b17bb
https://hal.archives-ouvertes.fr/hal-00767633

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