Výsledky vyhledávání - "Maximilian Meixner"

Dynamic Docking of Macrocycles in Bound and Unbound Protein Structures with DynaDock

Autor: Maximilian Meixner, Martin Zachmann, Sebastian Metzler, Jonathan Scheerer, Martin Zacharias, Iris Antes

Publikováno v: Journal of Chemical Information and Modeling. 62:3426-3441

Macrocycles are interesting molecules with unique features due to their conformationally constrained yet flexible ring structure. This characteristic poses a difficult challenge for computational modeling studies since they rely on accurate structura

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f19c5e6452c119c23918cfb83c41ac3e
https://doi.org/10.1021/acs.jcim.2c00436

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Acyldepsipeptide Probes Facilitate Specific Detection of Caseinolytic Protease P Independent of Its Oligomeric and Activity State

Autor: Heike Brötz-Oesterhelt, Barbara Eyermann, Iris Antes, Stephan A. Sieber, Maximilian Meixner

Publikováno v: Chembiochem

Caseinolytic protease P (ClpP) is a tetradecameric peptidase that assembles with chaperones such as ClpX to gain proteolytic activity. Acyldepsipeptides (ADEPs) are small‐molecule mimics of ClpX that bind into hydrophobic pockets on the apical site

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f2ac44287a720b5cf7b0feeee001387
http://europepmc.org/articles/PMC7003903

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A modular approach to the bisbenzylisoquinoline alkaloids tetrandrine and isotetrandrine

Autor: Ramona Schütz, Iris Antes, Maximilian Meixner, Franz Bracher

Publikováno v: Organic & Biomolecular Chemistry. 18:3047-3068

An efficient racemic total synthesis of the bisbenzylisoquinoline alkaloids tetrandrine and isotetrandrine in four different routes is reported herein. Key steps of the synthesis include N-acyl Pictet-Spengler condensations to access the tetrahydrois

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c00b78f9eaeb291cf05ab490301affe
https://doi.org/10.1039/d0ob00078g

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Turning the Actin Nucleating Compound Miuraenamide into Nucleation Inhibitors

Autor: Uli Kazmaier, Lisa Karmann, Lushuang Yu, Stefan Zahler, Ling Zhuo, Shuaijun Wang, Iris Antes, Angelika M. Vollmar, Maximilian Meixner

Publikováno v: ACS Omega
ACS Omega, Vol 6, Iss 34, Pp 22165-22172 (2021)

Natural compounds that either increase or decrease polymerization of actin into filaments have become indispensable tools for cell biology. However, to date, it was not possible to use them as therapeutics due to their overall cytotoxicity and their

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f66f3f0bd0e1f6356d3198727705dc36
https://mediatum.ub.tum.de/doc/1650353/document.pdf