Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Maximilian Kullmann"'
Autor:
Matthias Beat Wittwer, Dieudonné Tshitenge Tshitenge, Pierre-Luc Boudreault, Annie Doucet, Maximilian Kullmann, Joachim Mittendorf, Émilie Blaise, Florian Kölling, Alexander Hillisch, Christian Comeau, Marie-Pierre Collin, Lea Seep, Eric Marsault, Andreas H. Göller, Antoine Le Roux, Marilena Giarrusso, Thomas Neubauer
Publikováno v:
Journal of Medicinal Chemistry. 63:6774-6783
We herein report the first thorough analysis of the structure-permeability relationship of semipeptidic macrocycles. In total, 47 macrocycles were synthesized using a hybrid solid-phase/solution strategy, and then their passive and cellular permeabil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0233d450b6d70f6daea1d2fd2c80ac76
https://doi.org/10.1021/acs.jmedchem.0c00013
https://doi.org/10.1021/acs.jmedchem.0c00013
Autor:
Jörg Hüser, Philip Boehme, Peter Sandner, Peter Kolkhof, Thomas Mondritzki, Sarah M.L. Steinbach, Erwin Bischoff, Daniel Schock-Kusch, Julia Vogel, Jessica Hoffmann, Wilfried Dinh, Maximilian Kullmann, Hubert Truebel
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 90:7-12
Quantitative assessment of renal function by measurement of glomerular filtration rate (GFR) is an important part of safety and efficacy evaluation in preclinical drug development. Existing methods are often time consuming, imprecise and associated w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::140cd424aa8e8fffff7aa3d6bcddd8e8
https://doi.org/10.1016/j.vascn.2017.10.009
https://doi.org/10.1016/j.vascn.2017.10.009
Autor:
Malte Hellwig, Ralf A. Hilger, Ulrich Jaehde, Maximilian Kullmann, Ganna V. Kalayda, Sabine Metzger, Sandra Kotz
Publikováno v:
Journal of Inorganic Biochemistry. 153:247-252
Intracellular binding of cisplatin to non-DNA partners, such as proteins, has received increasing attention as an additional mode of action and as mechanism of resistance. We investigated two cisplatin-interacting isoforms of protein disulfide isomer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::639669f756ea0bbc99deb9db26f33fd4
https://doi.org/10.1016/j.jinorgbio.2015.08.028
https://doi.org/10.1016/j.jinorgbio.2015.08.028
Autor:
Sandra Kotz, Maximilian Kullmann, Ganna V. Kalayda, Nadine Dyballa-Rukes, Ulrich Jaehde, Sabine Metzger
Publikováno v:
ELECTROPHORESIS. 39
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ad7fdc3c030d3e6d7f4d4e90ae95229
https://doi.org/10.1002/elps.201870092
https://doi.org/10.1002/elps.201870092
Autor:
Ganna V. Kalayda, Sandra Kotz, Barbara Crone, Ulrich Jaehde, Maximilian Kullmann, Sabine Metzger
Publikováno v:
ELECTROPHORESIS. 36:2811-2819
Cisplatin is one of the most widely used anticancer agents, but a major problem for successful chemotherapy is the development of drug resistance of tumor cells against cisplatin. Resistance to cisplatin is a multifactorial problem. A method to detec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d177fe93c31aee8cf199029f878cf5d
https://doi.org/10.1002/elps.201500188
https://doi.org/10.1002/elps.201500188
Publikováno v:
ELECTROPHORESIS. 36:509-517
Pt-based anticancer drugs, such as cisplatin, are known to undergo several (bio-)chemical transformation steps after administration. Hydrolysis and adduct formation with small nucleophiles and larger proteins are their most relevant reactions on the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ee9a671617d41283a7095a603c86493
https://doi.org/10.1002/elps.201400467
https://doi.org/10.1002/elps.201400467
Autor:
Malte Hellwig, Sabine Metzger, Sandra Kotz, Ulrich Jaehde, Maximilian Kullmann, Ganna V. Kalayda
Publikováno v:
Int. Journal of Clinical Pharmacology and Therapeutics. 53:1038-1040
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b35b9b917217f9ee164223ad09d5204e
https://doi.org/10.5414/cpxces14ea02
https://doi.org/10.5414/cpxces14ea02
Autor:
Ganna V. Kalayda, Ulrich Jaehde, Sabine Metzger, Nadine Dyballa-Rukes, Sandra Kotz, Maximilian Kullmann
Publikováno v:
Electrophoresis. 39(12)
Intracellular binding of cisplatin to proteins has been associated with acquired resistance to chemotherapy. In our previous study we established an analytical method for the identification of intracellular cisplatin-binding proteins. The method used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a52d91b5565a1e4e4f1590941226819a
https://pubmed.ncbi.nlm.nih.gov/29676816
https://pubmed.ncbi.nlm.nih.gov/29676816
Publikováno v:
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry. 22(8)
Oxaliplatin is the backbone of chemotherapy for advanced colorectal cancer and undergoes clinical trials for treatment of other tumour entities. However, acquired resistance is a major hurdle. Confocal microscopy is a useful tool to get an insight in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1e3b75537f6c79e30e6d4f67c054323
https://pubmed.ncbi.nlm.nih.gov/29043454
https://pubmed.ncbi.nlm.nih.gov/29043454
Autor:
Sandra, Kotz, Maximilian, Kullmann, Barbara, Crone, Ganna V, Kalayda, Ulrich, Jaehde, Sabine, Metzger
Publikováno v:
Electrophoresis. 36(21-22)
Cisplatin is one of the most widely used anticancer agents, but a major problem for successful chemotherapy is the development of drug resistance of tumor cells against cisplatin. Resistance to cisplatin is a multifactorial problem. A method to detec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8e31ed7cb23f4d69fdef63b880e6ecab
https://pubmed.ncbi.nlm.nih.gov/26250553
https://pubmed.ncbi.nlm.nih.gov/26250553