Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Maximilian G, Plach"'
Publikováno v:
BMC Bioinformatics, Vol 18, Iss 1, Pp 1-13 (2017)
Abstract Background Large enzyme families may contain functionally diverse members that give rise to clusters in a sequence similarity network (SSN). In prokaryotes, the genome neighborhood of a gene-product is indicative of its function and thus, a
Externí odkaz:
https://doaj.org/article/4333c0531144484db589b8ca8c9fc58a
The sequence specific association of RNA with DNA via formation of RNA/DNA triple helices is relevant for regulation of gene expression, repair mechanisms, and chromatin organization. Formation of such RNA/DNA triplexes requires poly-purine sequences
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::897b28c9167490e26059c72218940d67
https://doi.org/10.1101/2022.11.21.517309
https://doi.org/10.1101/2022.11.21.517309
Publikováno v:
PLoS Genetics, Vol 12, Iss 1, p e1005836 (2016)
Modern enzymes are highly optimized biocatalysts that process their substrates with extreme efficiency. Many enzymes catalyze more than one reaction; however, the persistence of such ambiguities, their consequences and evolutionary causes are largely
Externí odkaz:
https://doaj.org/article/cb8be713e80e4c698076db6b927a6e73
Autor:
Jonathan Stauber, Maximilian G. Plach, Ahmed Hamaï, Jean-Pierre Baudoin, Philippe Halfon, Marie Novello, Madani Rachid, Eloïne Bestion, Zuzana Macek Jilkova, Soraya Mezouar, Lise Vanderlynden, Gilles Lalmanach, Gaël S. Roth, Raphael Legouffe, Jennifer Tracz, Thomas Schubert, Firas Bassissi, Thomas Decaens, Sonia Brun, Christelle Ansaldi, Cindy Serdjebi, Eric Raymond, Cyrille Drouot, Jérôme Courcambeck, Guillaume Jacquemot
Publikováno v:
Autophagy
Autophagy, 2022, 18 (3), pp.678-694. ⟨10.1080/15548627.2021.1988357⟩
Autophagy, Taylor & Francis, 2022, 18 (3), pp.678-694. ⟨10.1080/15548627.2021.1988357⟩
Autophagy, 2022, 18 (3), pp.678-694. ⟨10.1080/15548627.2021.1988357⟩
Autophagy, Taylor & Francis, 2022, 18 (3), pp.678-694. ⟨10.1080/15548627.2021.1988357⟩
International audience; Hepatocellular carcinoma is the most frequent primary liver cancer. Macroautophagy/autophagy inhibitors have been extensively studied in cancer but, to date, none has reached efficacy in clinical trials. In this study, we demo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::963947ad8357c65d781ce7a48a965de8
https://hal.science/hal-03677289
https://hal.science/hal-03677289
Autor:
Sonia, Brun, Eloïne, Bestion, Eric, Raymond, Firas, Bassissi, Zuzana Macek, Jilkova, Soraya, Mezouar, Madani, Rachid, Marie, Novello, Jennifer, Tracz, Ahmed, Hamaï, Gilles, Lalmanach, Lise, Vanderlynden, Raphael, Legouffe, Jonathan, Stauber, Thomas, Schubert, Maximilian G, Plach, Jérôme, Courcambeck, Cyrille, Drouot, Guillaume, Jacquemot, Cindy, Serdjebi, Gael, Roth, Jean-Pierre, Baudoin, Christelle, Ansaldi, Thomas, Decaens, Philippe, Halfon
Publikováno v:
Autophagy. 18(3)
Hepatocellular carcinoma is the most frequent primary liver cancer. Macroautophagy/autophagy inhibitors have been extensively studied in cancer but, to date, none has reached efficacy in clinical trials. In this study, we demonstrated that GNS561, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::23b1f81ed175fe2864bc202b9178e928
https://pubmed.ncbi.nlm.nih.gov/34740311
https://pubmed.ncbi.nlm.nih.gov/34740311
Autor:
Corinna Popp, Ralf Wagner, Maximilian G. Plach, David Peterhoff, Christian Kleusch, Philipp Schramm, Christopher Battle
Vaccines are on the front line-of-defense against infectious diseases, ranging from threats we are familiar with, including polio, tuberculosis, or HIV, to novel and emerging threats such as SARS-CoV-2. Successful development of new protein-based vac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb46ad387a1bbfc2df779c03bdd3c204
https://doi.org/10.1101/2020.11.30.403873
https://doi.org/10.1101/2020.11.30.403873
During the discovery and development of new drugs, candidates with undesired and potentially harmful side-effects can arise at all stages, which poses significant scientific and economic risks. Most of such phenotypic side-effects can be attributed t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb9e663d18d85a0238f35ba3160606ef
https://doi.org/10.1101/2020.07.24.219071
https://doi.org/10.1101/2020.07.24.219071
Accelerated development of lead structures is of high interest to the pharmaceutical industry in order to decrease development times and costs. We showcase how an intelligent combination of AI-based drug screening with state-of-the-art biophysics dri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e41fa82be739260eda0f405d47a5ec43
Publikováno v:
Angewandte Chemie. 127:11423-11427
Chorismat-umsetzende Enzyme spielen in Pflanzen sowie frei lebenden und infektiosen Mikroorganismen eine entscheidende Rolle bei der Biosynthese zahlreicher Metabolite. Zu diesen Enzymen zahlen die primarmetabolische Anthranilatsynthase (AS) und die
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::800ddc47988bd2efe9f64038ecca60ca
https://doi.org/10.1002/ange.201505063
https://doi.org/10.1002/ange.201505063
Publikováno v:
Bio Protoc
Protein-peptide interactions are part of many physiological processes, for example, epigenetics where peptide regions of histone complexes are crucial for regulation of chromatin structure. Short peptides are often also used as alternatives to small
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec7d4bf66e2296f2a052741b1c92c46f
https://europepmc.org/articles/PMC8438368/
https://europepmc.org/articles/PMC8438368/