Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Maximilian F Konig"'
Autor:
Evan J Lipson, Jarushka Naidoo, Julie Brahmer, Ludmila Danilova, Elizabeth M Jaffee, Won Jin Ho, Mark Yarchoan, Maximilian F Konig, Yasser Ged, Jean Hoffman-Censits, Jennifer Durham, Laura Cappelli, Sanjay Bansal, Aanika Balaji, Rajat Mohindra, Stephanie L Alden, Tanguy Y Seiwert, Chester J Kao, Soren Charmsaz, Madalena Brancati, Howard L Li, Kabeer Munjal, Hua-Ling Tsai, Alexei Hernandez, Nicole Gross, Erin M Coyne, Sarah M Shin, Brian Christmas, Christopher Thoburn, Marina Barretti, Rachel Garonce-Hediger, Laura Tang, G Scott Chandler
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/9ecf458f7da7428ea7c6e82123a0c044
Autor:
Allison Koenecke, Michael Powell, Ruoxuan Xiong, Zhu Shen, Nicole Fischer, Sakibul Huq, Adham M Khalafallah, Marco Trevisan, Pär Sparen, Juan J Carrero, Akihiko Nishimura, Brian Caffo, Elizabeth A Stuart, Renyuan Bai, Verena Staedtke, David L Thomas, Nickolas Papadopoulos, Ken W Kinzler, Bert Vogelstein, Shibin Zhou, Chetan Bettegowda, Maximilian F Konig, Brett D Mensh, Joshua T Vogelstein, Susan Athey
Publikováno v:
eLife, Vol 10 (2021)
In severe viral pneumonia, including Coronavirus disease 2019 (COVID-19), the viral replication phase is often followed by hyperinflammation, which can lead to acute respiratory distress syndrome, multi-organ failure, and death. We previously demonst
Externí odkaz:
https://doaj.org/article/27cc1efbc7b74373ace05076206c199b
Autor:
Michael S. Hwang, Michelle S. Miller, Puchong Thirawatananond, Jacqueline Douglass, Katharine M. Wright, Emily Han-Chung Hsiue, Brian J. Mog, Tihitina Y. Aytenfisu, Michael B. Murphy, P. Aitana Azurmendi, Andrew D. Skora, Alexander H. Pearlman, Suman Paul, Sarah R. DiNapoli, Maximilian F. Konig, Chetan Bettegowda, Drew M. Pardoll, Nickolas Papadopoulos, Kenneth W. Kinzler, Bert Vogelstein, Shibin Zhou, Sandra B. Gabelli
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Chimeric antigen receptor T cells in the clinic currently target cell-type-specific extracellular antigens on malignant cells. Here, authors engineer tumor-specific chimeric antigen receptor T cells that target human leukocyte antigen-presented neoan
Externí odkaz:
https://doaj.org/article/fff72ea490f640af8b0aeee032442ea5
Autor:
Shilong Li, Tomi Jun, Jonathan Tyler, Emilio Schadt, Yu-Han Kao, Zichen Wang, Maximilian F. Konig, Chetan Bettegowda, Joshua T. Vogelstein, Nickolas Papadopoulos, Ramon E. Parsons, Rong Chen, Eric E. Schadt, Li Li, William K. Oh
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
Apha-1-adrenergic receptor antagonists (α1-blockers) can suppress pro-inflammatory cytokines, thereby potentially improving outcomes among patients with COVID-19. Accordingly, we evaluated the association between α1-blocker exposure (before or duri
Externí odkaz:
https://doaj.org/article/1575e73295f84b33af980c1f36a8943b
Publikováno v:
ACR Open Rheumatology, Vol 2, Iss 8, Pp 491-495 (2020)
Objective The recent hydroxychloroquine (HCQ) shortage due to use in coronavirus disease 2019 (COVID‐19) has forced some rheumatic disease patients to choose between continuing their current dose of HCQ but exhaust their supply early or ration it i
Externí odkaz:
https://doaj.org/article/ccbf1f2db8424eb68be212582ebf0c74
Autor:
Gabriel D. Román-Meléndez, Daniel R. Monaco, Janelle M. Montagne, Rachel S. Quizon, Maximilian F. Konig, Mekbib Astatke, Erika Darrah, H. Benjamin Larman
Publikováno v:
EBioMedicine, Vol 71, Iss , Pp 103506- (2021)
Background: Post-translational modifications (PTMs) on proteins can be targeted by antibodies associated with autoimmunity. Despite a growing appreciation for their intrinsic role in disease, there is a lack of highly multiplexed serological assays t
Externí odkaz:
https://doaj.org/article/82af569aa0244ab8905c2ce7c8ac7508
Autor:
Michael Powell, Allison Koenecke, James Brian Byrd, Akihiko Nishimura, Maximilian F. Konig, Ruoxuan Xiong, Sadiqa Mahmood, Vera Mucaj, Chetan Bettegowda, Liam Rose, Suzanne Tamang, Adam Sacarny, Brian Caffo, Susan Athey, Elizabeth A. Stuart, Joshua T. Vogelstein
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Since the beginning of the COVID-19 pandemic, pharmaceutical treatment hypotheses have abounded, each requiring careful evaluation. A randomized controlled trial generally provides the most credible evaluation of a treatment, but the efficiency and e
Externí odkaz:
https://doaj.org/article/fae7cd43e08745a9a145a42d36922e6e
Autor:
Roger S. Zou, Yang Liu, Oscar E. Reyes Gaido, Maximilian F. Konig, Brian J. Mog, Leo L. Shen, Franklin Aviles-Vazquez, Alberto Marin-Gonzalez, Taekjip Ha
Publikováno v:
Nature Methods. 20:706-713
Discovery of off-target CRISPR–Cas activity in patient-derived cells and animal models is crucial for genome editing applications, but currently exhibits low sensitivity. We demonstrate that inhibition of DNA-dependent protein kinase catalytic subu
Autor:
Alvise Berti, Sophie Hillion, Maximilian F. Konig, Marta Casal Moura, Amber M. Hummel, Eva Carmona, Tobias Peikert, Fernando C. Fervenza, Cees G.M. Kallenberg, Carol A. Langford, Peter A. Merkel, Paul A. Monach, Philip Seo, Robert F. Spiera, Paul Brunetta, E. William St. Clair, Kristina M. Harris, John H. Stone, Guido Grandi, Jacques‐Olivier Pers, Ulrich Specks, Divi Cornec
Publikováno v:
Arthritis & Rheumatology. 75:736-747
Autor:
Liam Rose, Laura Graham, Allison Koenecke, Michael Powell, Ruoxuan Xiong, Zhu Shen, Brett Mench, Kenneth W. Kinzler, Chetan Bettegowda, Bert Vogelstein, Susan Athey, Joshua T. Vogelstein, Maximilian F. Konig, Todd H. Wagner
Publikováno v:
Frontiers in Medicine, Vol 8 (2021)
Effective therapies for coronavirus disease 2019 (COVID-19) are urgently needed, and pre-clinical data suggest alpha-1 adrenergic receptor antagonists (α1-AR antagonists) may be effective in reducing mortality related to hyperinflammation independen
Externí odkaz:
https://doaj.org/article/ab4b9d51ba514d2ba03c96c9867208a1