Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Maximilian F, Schmidt"'
Autor:
Geng Chen, Jun Xu, Asuka Inoue, Maximilian F. Schmidt, Chen Bai, Qiuyuan Lu, Peter Gmeiner, Zheng Liu, Yang Du
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
GPR88 is an orphan GPCR and regulates diverse brain functions. Here, the authors report two structures of the human GPR88-Gi complex, showing an allosteric ligand directly involved in the interaction interface between the receptor and G-protein, and
Externí odkaz:
https://doaj.org/article/eee1acc6cff34c06b53a0cef0eeb9892
Autor:
Anni Allikalt, Nirupam Purkayastha, Khajidmaa Flad, Maximilian F. Schmidt, Alina Tabor, Peter Gmeiner, Harald Hübner, Dorothee Weikert
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Abstract Fluorescent ligands are versatile tools for the study of G protein-coupled receptors. Depending on the fluorophore, they can be used for a range of different applications, including fluorescence microscopy and bioluminescence or fluorescence
Externí odkaz:
https://doaj.org/article/917ec5091e204abdb7245329c218d9c8
Autor:
Fabian J Ertl, Adam Konieczny, Peter Gmeiner, Eduard Neu, Marcus Conrad, Max Keller, Jakob Gleixner, Timothy Clark, Lukas Grätz, Albert O Gattor, Anselm H. C. Horn, Maximilian F. Schmidt, David Wifling, Heinrich Sticht
Publikováno v:
Journal of Medicinal Chemistry. 64:16746-16769
The family of neuropeptide Y (NPY) receptors comprises four subtypes (Y1R, Y2R, Y4R, Y5R), which are addressed by at least three endogenous peptides, i.e., NPY, peptide YY, and pancreatic polypeptide (PP), the latter showing a preference for Y4R. A s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3cb4b9a316170dbb55865a63f314e719
https://doi.org/10.1021/acs.jmedchem.1c01574
https://doi.org/10.1021/acs.jmedchem.1c01574
Autor:
Elissa A. Fink, Jun Xu, Harald Hübner, Joao M. Braz, Philipp Seemann, Charlotte Avet, Veronica Craik, Dorothee Weikert, Maximilian F. Schmidt, Chase M. Webb, Nataliya A. Tolmachova, Yurii S. Moroz, Xi-Ping Huang, Chakrapani Kalyanaraman, Stefan Gahbauer, Geng Chen, Zheng Liu, Matthew P. Jacobson, John J. Irwin, Michel Bouvier, Yang Du, Brian K. Shoichet, Allan I. Basbaum, Peter Gmeiner
Publikováno v:
Science. 377
Because nonopioid analgesics are much sought after, we computationally docked more than 301 million virtual molecules against a validated pain target, the α 2A -adrenergic receptor (α 2A AR), seeking new α 2A AR agonists chemotypes that lack the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8d0d773df6654433617ced8c92103ff
https://doi.org/10.1126/science.abn7065
https://doi.org/10.1126/science.abn7065
Autor:
Ranit Lahmy, Harald Hübner, Maximilian F. Schmidt, Daniel Lachmann, Peter Gmeiner, Burkhard König
Photoswitchable ligands as biological tools provide an opportunity to explore the kinetics and dynamics of the clinically relevant µ-opioid receptor. These ligands can potentially activate and deactivate the receptor when desired, using light. Spati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc52209bb7d0e341922ccd34b27f4f62
https://epub.uni-regensburg.de/53254/
https://epub.uni-regensburg.de/53254/
Autor:
Leonhard Schill, Peter Wasserscheid, Jakob Albert, Patrick Schühle, Anders Riisager, Maximilian F. Schmidt
Publikováno v:
Catalysis Science & Technology. 10:7309-7322
In this study, the performance of an In2O3/ZrO2 catalyst for hydrogenation of CO2 to methanol is reported in the presence of typical impurities of industrial CO2 feed gas streams. Experiments were performed with defined amounts of SO2, H2S, NO2, NH3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb4e06d66fe98cd6604f39f3d235f196
https://doi.org/10.1039/d0cy00946f
https://doi.org/10.1039/d0cy00946f
Autor:
Max E. Huber, Lara Toy, Maximilian F. Schmidt, Hannah Vogt, Julian Budzinski, Martin F. J. Wiefhoff, Nicole Merten, Evi Kostenis, Dorothee Weikert, Matthias Schiedel
Publikováno v:
Angewandte Chemie International Edition. 61
A conserved intracellular allosteric binding site (IABS) has recently been identified at several G protein-coupled receptors (GPCRs). Starting from vercirnon, an intracellular C-C chemokine receptor type 9 (CCR9) antagonist and previous phase III cli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3fef5fb7fb05c5e95175d7b5144c09e
https://doi.org/10.1002/anie.202116782
https://doi.org/10.1002/anie.202116782
Autor:
Max E. Huber, Lara Toy, Maximilian F. Schmidt, Hannah Vogt, Julian Budzinski, Martin F. J. Wiefhoff, Nicole Merten, Evi Kostenis, Dorothee Weikert, Matthias Schiedel
Publikováno v:
Angewandte Chemie. 134
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27b38a71aadee7241e3c14f8d46eb5d0
https://doi.org/10.1002/ange.202116782
https://doi.org/10.1002/ange.202116782
Autor:
Adam, Konieczny, Marcus, Conrad, Fabian J, Ertl, Jakob, Gleixner, Albert O, Gattor, Lukas, Grätz, Maximilian F, Schmidt, Eduard, Neu, Anselm H C, Horn, David, Wifling, Peter, Gmeiner, Timothy, Clark, Heinrich, Sticht, Max, Keller
Publikováno v:
Journal of medicinal chemistry. 64(22)
The family of neuropeptide Y (NPY) receptors comprises four subtypes (Y
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::06ae17ee13f57172c60c7cf1e7513fdb
https://pubmed.ncbi.nlm.nih.gov/34748345
https://pubmed.ncbi.nlm.nih.gov/34748345
Publikováno v:
Bioorganic & Medicinal Chemistry. 61:116720
A broadly applicable synthesis of peptides incorporating mixed disulfides between cysteine and homocysteine and cysteamine was developed. The method was established using pharmacologically relevant G protein-coupled receptor (GPCR) ligands including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12eedde6af376046313c74dcb66f0235
https://doi.org/10.1016/j.bmc.2022.116720
https://doi.org/10.1016/j.bmc.2022.116720