Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Maximilian Englert"'
Autor:
Xiaojuan Zhao, Dominic Alibhai, Tony G. Walsh, Nathalie Tarassova, Maximilian Englert, Semra Z. Birol, Yong Li, Christopher M. Williams, Chris R. Neal, Philipp Burkard, Stephen J. Cross, Elizabeth W. Aitken, Amie K. Waller, José Ballester Beltrán, Peter W. Gunning, Edna C. Hardeman, Ejaife O. Agbani, Bernhard Nieswandt, Ingeborg Hers, Cedric Ghevaert, Alastair W. Poole
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Platelets, small hemostatic blood cells, are derived from megakaryocytes. Both bone marrow and lung are principal sites of thrombopoiesis although underlying mechanisms remain unclear. Outside the body, however, our ability to generate large
Externí odkaz:
https://doaj.org/article/b34379c46b594e3991173e9d3c71b0ac
Autor:
Amro Elgheznawy, Patricia Öftering, Maximilian Englert, Kristina Mott, Friederike Kaiser, Charly Kusch, Uwe Gbureck, Michael R. Bösl, Harald Schulze, Bernhard Nieswandt, Timo Vögtle, Heike M. Hermanns
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Zinc (Zn2+) is considered as important mediator of immune cell function, thrombosis and haemostasis. However, our understanding of the transport mechanisms that regulate Zn2+ homeostasis in platelets is limited. Zn2+ transporters, ZIPs and ZnTs, are
Externí odkaz:
https://doaj.org/article/910106bae0214b969371100e54cf7a15
Autor:
Isabelle C. Becker, Zoltan Nagy, Georgi Manukjan, Melanie Haffner-Luntzer, Maximilian Englert, Tobias Heib, Timo Vögtle, Carina Gross, Richa Bharti, Sascha Dietrich, Kristina Mott, Johannes Heck, Sebastian Stegmaier, Anke Baranowsky, Thorsten Schinke, Nicolas Schlegel, Tobias Heckel, David Stegner, Irina Pleines, Anita Ignatius, Harald Schulze, Bernhard Nieswandt
Publikováno v:
Blood Advances. 6:3155-3161
G6b-B is a megakaryocyte lineage-specific immunoreceptor tyrosine-based inhibition motif–containing receptor, essential for platelet homeostasis. Mice with a genomic deletion of the entire Mpig6b locus develop severe macrothrombocytopenia and myelo
Autor:
Xiaojuan Zhao, Dominic Alibhai, Tony Walsh, Nathalie Tarassova, Maximilian Englert, Semra Birol, Yong Li, Christopher Williams, Chris Neal, Philipp Burkard, Elizabeth Aitken, Amie Waller, Jose Ballester-Beltran, Peter Gunning, Edna Hardeman, Ejaife Agbani, Bernhard Nieswandt, Ingeborg Hers, Cedric Ghevaert, Alastair Poole
Platelets, small hemostatic blood cells, are derived from megakaryocytes (MKs). It is accepted that both bone marrow (BM) and lung are principal sites of thrombogenesis although underlying mechanisms remain unclear. Outside the body, however, our abi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69a2c2e4cf3f2a9ac181c5917b07d49e
https://doi.org/10.21203/rs.3.rs-2306404/v1
https://doi.org/10.21203/rs.3.rs-2306404/v1
Autor:
Maximilian Englert, Katja Aurbach, Isabelle C. Becker, Annika Gerber, Tobias Heib, Lou M. Wackerbarth, Charly Kusch, Kristina Mott, Gabriel H. M. Araujo, Ayesha A. Baig, Sebastian Dütting, Ulla G. Knaus, Christian Stigloher, Harald Schulze, Bernhard Nieswandt, Irina Pleines, Zoltan Nagy
Publikováno v:
Blood advances. 6(17)
Megakaryocytes are large cells in the bone marrow that give rise to blood platelets. Platelet biogenesis involves megakaryocyte maturation, the localization of the mature cells in close proximity to bone marrow sinusoids, and the formation of protrus
Autor:
Maximilian Englert, Katja Aurbach, Annika Gerber, Tobias Heib, Isabelle C. Becker, Lou M. Wackerbarth, Charly Kusch, Ayesha A. Baig, Sebastian Dütting, Ulla G. Knaus, Christian Stigloher, Bernhard Nieswandt, Irina Pleines, Zoltan Nagy
Megakaryocytes are large cells in the bone marrow, which give rise to blood platelets. Platelet biogenesis involves megakaryocyte maturation, the localization of mature cells in close proximity to bone marrow sinusoids and the formation of protrusion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5accdc4725084be9b4a9b50f4f7c76d4
https://doi.org/10.1101/2021.11.04.467272
https://doi.org/10.1101/2021.11.04.467272
Autor:
Annika Gerber, Isabelle C. Becker, Heike M. Hermanns, Philipp Burkard, Mara Meub, Bernhard Nieswandt, Charly Kusch, Deya Cherpokova, Daniel Jahn, Harald Schulze, Cord Brakebusch, Tobias Heib, Georgi Manukjan, Zoltan Nagy, Maximilian Englert, Thomas Dandekar, Irina Pleines, Christian Stigloher, Johannes Balkenhol, Sarah Beck, Lou Martha Wackerbarth, Sebastian Dütting, Markus Sauer
Publikováno v:
Heib, T, Hermanns, H M, Manukjan, G, Englert, M, Kusch, C, Becker, I C, Gerber, A, Wackerbarth, L M, Burkard, P, Dandekar, T, Balkenhol, J, Jahn, D, Beck, S, Meub, M, Dütting, S, Stigloher, C, Sauer, M, Cherpokova, D, Schulze, H, Brakebusch, C, Nieswandt, B, Nagy, Z & Pleines, I 2021, ' RhoA/Cdc42 signaling drives cytoplasmic maturation but not endomitosis in megakaryocytes ', Cell Reports, vol. 35, no. 6, pp. 109102 . https://doi.org/10.1016/j.celrep.2021.109102
Summary Megakaryocytes (MKs), the precursors of blood platelets, are large, polyploid cells residing mainly in the bone marrow. We have previously shown that balanced signaling of the Rho GTPases RhoA and Cdc42 is critical for correct MK localization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24b4b43aea7a435a9277628b412b7b5e
https://curis.ku.dk/ws/files/271679450/1_s2.0_S2211124721004368_main.pdf
https://curis.ku.dk/ws/files/271679450/1_s2.0_S2211124721004368_main.pdf