Výsledky vyhledávání - "Maximilian A. Kelch"

Akademický článek

Machine learning on large scale perturbation screens for SARS-CoV-2 host factors identifies β-catenin/CBP inhibitor PRI-724 as a potent antiviral

Autor: Maximilian A. Kelch, Antonella Vera-Guapi, Thomas Beder, Marcus Oswald, Alicia Hiemisch, Nina Beil, Piotr Wajda, Sandra Ciesek, Holger Erfle, Tuna Toptan, Rainer Koenig

Publikováno v: Frontiers in Microbiology, Vol 14 (2023)

Expanding antiviral treatment options against SARS-CoV-2 remains crucial as the virus evolves under selection pressure which already led to the emergence of several drug resistant strains. Broad spectrum host-directed antivirals (HDA) are promising t

Externí odkaz: https://doaj.org/article/05c0f34c61634c5bbd7d2b6ac3cac832

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Akademický článek

Molecular Analyses of Clinical Isolates and Recombinant SARS-CoV-2 Carrying B.1 and B.1.617.2 Spike Mutations Suggest a Potential Role of Non-Spike Mutations in Infection Kinetics

Autor: Andrei Veleanu, Maximilian A. Kelch, Chengjin Ye, Melanie Flohr, Alexander Wilhelm, Marek Widera, Luis Martinez-Sobrido, Sandra Ciesek, Tuna Toptan

Publikováno v: Viruses, Vol 14, Iss 9, p 2017 (2022)

Some of the emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants are less susceptible to neutralization with post-vaccine sera and monoclonal antibodies targeting the viral spike glycoprotein. This raises concerns of disease

Externí odkaz: https://doaj.org/article/1106142ef8f94fb19fbe3061d8dab7c7

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Akademický článek

Equine Alphaherpesviruses Require Activation of the Small GTPases Rac1 and Cdc42 for Intracellular Transport

Autor: Oleksandr Kolyvushko, Maximilian A. Kelch, Nikolaus Osterrieder, Walid Azab

Publikováno v: Microorganisms, Vol 8, Iss 7, p 1013 (2020)

Viruses utilize host cell signaling to facilitate productive infection. Equine herpesvirus type 1 (EHV-1) has been shown to activate Ca2+ release and phospholipase C upon contact with α4β1 integrins on the cell surface. Signaling molecules, includi

Externí odkaz: https://doaj.org/article/feb894bb254a48729c1bce6c9929ca76

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