Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Maximilian, Wranik"'
Autor:
Maximilian Wranik, Michal W. Kepa, Emma V. Beale, Daniel James, Quentin Bertrand, Tobias Weinert, Antonia Furrer, Hannah Glover, Dardan Gashi, Melissa Carrillo, Yasushi Kondo, Robin T. Stipp, Georgii Khusainov, Karol Nass, Dmitry Ozerov, Claudio Cirelli, Philip J. M. Johnson, Florian Dworkowski, John H. Beale, Scott Stubbs, Thierry Zamofing, Marco Schneider, Kristina Krauskopf, Li Gao, Oliver Thorn-Seshold, Christoph Bostedt, Camila Bacellar, Michel O. Steinmetz, Christopher Milne, Jörg Standfuss
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Serial crystallography at X-ray free-electron lasers (XFELs) permits the determination of radiation-damage free static as well as time-resolved protein structures at room temperature. Efficient sample delivery is a key factor for such experi
Externí odkaz:
https://doaj.org/article/f224092cc9184c46b2af0e3942817cf2
Autor:
Maximilian Wranik, Tobias Weinert, Chavdar Slavov, Tiziana Masini, Antonia Furrer, Natacha Gaillard, Dario Gioia, Marco Ferrarotti, Daniel James, Hannah Glover, Melissa Carrillo, Demet Kekilli, Robin Stipp, Petr Skopintsev, Steffen Brünle, Tobias Mühlethaler, John Beale, Dardan Gashi, Karol Nass, Dmitry Ozerov, Philip J. M. Johnson, Claudio Cirelli, Camila Bacellar, Markus Braun, Meitian Wang, Florian Dworkowski, Chris Milne, Andrea Cavalli, Josef Wachtveitl, Michel O. Steinmetz, Jörg Standfuss
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Photopharmacology manipulates the biological activity of small molecules by light. Using an X-ray laser, the authors follow the release of the drug azo-combretastatin A4 from tubulin and the concomitant structural changes over nine orders of magnitud
Externí odkaz:
https://doaj.org/article/31ccc9f5c1c7420b8b23b5fa45bdc9ee
Autor:
Maximilian Wranik, Tobias Weinert, Chavdar Slavov, Tiziana Masini, Antonia Furrer, Natacha Gaillard, Dario Gioia, Marco Ferrarotti, Daniel James, Hannah Glover, Melissa Carrillo, Demet Kekilli, Robin Stipp, Petr Skopintsev, Steffen Brünle, Tobias Mühlethaler, John Beale, Dardan Gashi, Karol Nass, Dmitry Ozerov, Philip Johnson, Claudio Cirelli, Camila Bacellar, Markus Braun, Meitian Wang, Florian Dworkowski, Christopher Milne, Andrea Cavalli, Josef Wachtveitl, Michel Steinmetz, Jörg Standfuss
The binding and release of ligands from their protein targets is central to fundamental biological processes as well as to drug discovery. Photopharmacology introduces chemical triggers that allow the changing of ligand affinities and thus biological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a72c6a2aafb8c867ef93395e8b9fb46
https://doi.org/10.21203/rs.3.rs-1964458/v1
https://doi.org/10.21203/rs.3.rs-1964458/v1
Autor:
Tobias, Mühlethaler, Natacha, Olieric, Valentin A, Ehrhard, Maximilian, Wranik, Jörg, Standfuss, Ashwani, Sharma, Andrea E, Prota, Michel O, Steinmetz
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2430
Since the first moderate resolution, structural description of Taxol bound to tubulin by electron crystallography in 1998, several tubulin crystal systems have been developed and optimized for the high-resolution analysis of tubulin-ligand complexes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4ca190ebc2b55e0f93a1e7e921339d7d
https://pubmed.ncbi.nlm.nih.gov/35476344
https://pubmed.ncbi.nlm.nih.gov/35476344
Autor:
Andrea Cellini, Madan Kumar Shankar, Weixiao Yuan Wahlgren, Amke Nimmrich, Antonia Furrer, Daniel James, Maximilian Wranik, Sylvain Aumonier, Emma V. Beale, Florian Dworkowski, Jörg Standfuss, Tobias Weinert, Sebastian Westenhoff
Publikováno v:
Chemical communications (Cambridge, England). 58(31)
We present the structure of a photoactivated animal (6-4) photolyase in its radical pair state, captured by serial crystallography. We observe how a conserved asparigine moves towards the semiquinone FAD chromophore and stabilizes it by hydrogen bond
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce68d785b39fd389843eed1778d168a7
https://pubmed.ncbi.nlm.nih.gov/35352724
https://pubmed.ncbi.nlm.nih.gov/35352724
Autor:
Maximilian Wranik, Tobias Weinert, Chavdar Slavov, Tiziana Masini, Antonia Furrer, Natacha Gaillard, Dario Gioia, Marco Ferrarotti, Daniel James, Hannah Glover, Melissa Carrillo, Demet Kekilli, Robin Stipp, Petr Skopintsev, Steffen Brünle, Tobias Mühlethaler, John Beale, Dardan Gashi, Karol Nass, Dmitry Ozerov, Philip J. M. Johnson, Claudio Cirelli, Camila Bacellar, Markus Braun, Meitian Wang, Florian Dworkowski, Chris Milne, Andrea Cavalli, Josef Wachtveitl, Michel O. Steinmetz, Jörg Standfuss
The binding and release of ligands from their protein targets is central to fundamental biological processes as well as to drug discovery. Photopharmacology introduces chemical triggers that allow the changing of ligand affinities and thus biological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a3b074b5607c81bb186b5535b59bd61
https://doi.org/10.1101/2022.02.17.480857
https://doi.org/10.1101/2022.02.17.480857
Autor:
Sandra Mous, Guillaume Gotthard, David Ehrenberg, Saumik Sen, Tobias Weinert, Philip J. M. Johnson, Daniel James, Karol Nass, Antonia Furrer, Demet Kekilli, Pikyee Ma, Steffen Brünle, Cecilia Maria Casadei, Isabelle Martiel, Florian Dworkowski, Dardan Gashi, Petr Skopintsev, Maximilian Wranik, Gregor Knopp, Ezequiel Panepucci, Valerie Panneels, Claudio Cirelli, Dmitry Ozerov, Gebhard F. X. Schertler, Meitian Wang, Chris Milne, Joerg Standfuss, Igor Schapiro, Joachim Heberle, Przemyslaw Nogly
Publikováno v:
Science, 375 (6583)
Chloride transport by microbial rhodopsins is an essential process for which molecular details such as the mechanisms that convert light energy to drive ion pumping and ensure the unidirectionality of the transport have remained elusive. We combined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f35f634ac8aece2e2b68abccfcc8e1e
https://pubmed.ncbi.nlm.nih.gov/35597714
https://pubmed.ncbi.nlm.nih.gov/35597714
Autor:
Tobias Mühlethaler, Natacha Olieric, Valentin A. Ehrhard, Maximilian Wranik, Jörg Standfuss, Ashwani Sharma, Andrea E. Prota, Michel O. Steinmetz
Publikováno v:
Methods in Molecular Biology ISBN: 9781071619827
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8db629967af5e0d5921879a7ffd88a44
https://doi.org/10.1007/978-1-0716-1983-4_23
https://doi.org/10.1007/978-1-0716-1983-4_23