Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Maximilian, Klingler"'
Autor:
Anton Amadeus Hörmann, Maximilian Klingler, Christine Rangger, Christian Mair, Lieke Joosten, Gerben M. Franssen, Peter Laverman, Elisabeth von Guggenberg
Publikováno v:
Pharmaceutics, Vol 15, Iss 3, p 796 (2023)
The therapeutic potential of minigastrin (MG) analogs for the treatment of cholecystokinin-2 receptor (CCK2R)-expressing cancers is limited by poor in vivo stability or unfavorable accumulation in non-target tissues. Increased stability against metab
Externí odkaz:
https://doaj.org/article/cce9ff54695d4e17bf4864ac9c1fe04e
Autor:
Taraneh Sadat Zavvar, Anton Amadeus Hörmann, Maximilian Klingler, Dominik Summer, Christine Rangger, Laurence Desrues, Hélène Castel, Pierrick Gandolfo, Elisabeth von Guggenberg
Publikováno v:
Pharmaceuticals, Vol 16, Iss 2, p 278 (2023)
Different attempts have been made in the past two decades to develop radiolabeled peptide conjugates with enhanced pharmacokinetic properties in order to improve the application for tumor imaging and peptide receptor radionuclide therapy (PRRT), whic
Externí odkaz:
https://doaj.org/article/3a432039ee8f46c0a37d73acde50cea6
Autor:
Anton Amadeus Hörmann, Elisabeth Plhak, Maximilian Klingler, Christine Rangger, Joachim Pfister, Gert Schwach, Herbert Kvaternik, Elisabeth von Guggenberg
Publikováno v:
Molecules, Vol 27, Iss 6, p 2034 (2022)
The new minigastrin analog DOTA-MGS8 targeting the cholecystokinin-2 receptor (CCK2R) used in this study displays the combination of two site-specific modifications within the C-terminal receptor binding sequence together with an additional N-termina
Externí odkaz:
https://doaj.org/article/9a29287298c147499a41e800a70a5f70
Autor:
Anton A. Hörmann, Maximilian Klingler, Christine Rangger, Christian Mair, Clemens Decristoforo, Christian Uprimny, Irene J. Virgolini, Elisabeth von Guggenberg
Publikováno v:
Pharmaceuticals, Vol 14, Iss 6, p 575 (2021)
The new minigastrin analog DOTA-MGS5 is a promising new candidate for targeting cholecystokinin-2 receptor (CCK2R)-expressing tumors. To enable the clinical translation of PET/CT imaging using 68Ga-labeled DOTA-MGS5, different quality and safety aspe
Externí odkaz:
https://doaj.org/article/4c41814db8d44ae7ac2cda8bb2f878c5
Autor:
Anton Amadeus Hörmann, Maximilian Klingler, Maliheh Rezaeianpour, Nikolas Hörmann, Ronald Gust, Soraya Shahhosseini, Elisabeth von Guggenberg
Publikováno v:
Molecules, Vol 25, Iss 19, p 4585 (2020)
Targeting of cholecystokinin-2 receptor (CCK2R) expressing tumors using radiolabeled minigastrin (MG) analogs is hampered by rapid digestion of the linear peptide in vivo. In this study, a new MG analog stabilized against enzymatic degradation was in
Externí odkaz:
https://doaj.org/article/7d39313b415b4ef09526dd3001e887de
Autor:
Dominik Summer, Milos Petrik, Sonja Mayr, Martin Hermann, Piriya Kaeopookum, Joachim Pfister, Maximilian Klingler, Christine Rangger, Hubertus Haas, Clemens Decristoforo
Publikováno v:
Molecules, Vol 25, Iss 9, p 2123 (2020)
Hybrid imaging combining the beneficial properties of radioactivity and optical imaging within one imaging probe has gained increasing interest in radiopharmaceutical research. In this study, we modified the macrocyclic gallium-68 chelator fusarinine
Externí odkaz:
https://doaj.org/article/a1fe3680b67b440e9c9fac1e1c5bfea4
Autor:
Dominik Summer, Andrea Kroess, Rudolf Woerndle, Christine Rangger, Maximilian Klingler, Hubertus Haas, Leopold Kremser, Herbert H Lindner, Elisabeth von Guggenberg, Clemens Decristoforo
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0201224 (2018)
Positron emission tomography (PET) with radiolabelled peptide-based tracers has attracted great interest in oncology over the past decades. The success of imaging is closely related to sufficient uptake of the radiotracer in malignant tissue and for
Externí odkaz:
https://doaj.org/article/5ee1cb43faf9484e8f76b7154f482b32
Autor:
Anton Amadeus Hörmann, Maximilian Klingler, Christine Rangger, Christian Mair, Lieke Joosten, Gerben M. Franssen, Peter Laverman, Elisabeth von Guggenberg
Minigastrin (MG) analogs for therapy of CCK2R-expressing malignancies are limited by low stability in vivo or excessive accumulation in non-target organs. By modifying the C-terminal receptor-binding sequence, metabolization could be prevented and tu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9c61ef1bd30f5337400a6e6a3d9f3ec
https://doi.org/10.20944/preprints202209.0198.v1
https://doi.org/10.20944/preprints202209.0198.v1
Autor:
Maximilian Klingler, Christine Rangger, Dominik Summer, Piriya Kaeopookum, Clemens Decristoforo, Elisabeth von Guggenberg
Publikováno v:
Pharmaceuticals, Vol 12, Iss 2, p 88 (2019)
In our paper [...]
Externí odkaz:
https://doaj.org/article/9ee2e2a042a7436793a012b363dbc59f
Autor:
Maximilian Klingler, Christine Rangger, Dominik Summer, Piriya Kaeopookum, Clemens Decristoforo, Elisabeth von Guggenberg
Publikováno v:
Pharmaceuticals, Vol 12, Iss 1, p 13 (2019)
The high overexpression of cholecystokinin-2 receptors (CCK2R) in tumors, such as medullary thyroid carcinoma, allows for highly specific diagnostic and therapeutic targeting with radiolabeled peptide probes derived from natural ligands for the recep
Externí odkaz:
https://doaj.org/article/6853eb8a6e2d438b8272454ed1460fb7