Stem cells propagate their DNA by random segregation in the flatworm Macrostomum lignano.

Autor: Freija Verdoodt, Maxime Willems, Stijn Mouton, Katrien De Mulder, Wim Bert, Wouter Houthoofd, Julian Smith, Peter Ladurner

Publikováno v: PLoS ONE, Vol 7, Iss 1, p e30227 (2012)

Adult stem cells are proposed to have acquired special features to prevent an accumulation of DNA-replication errors. Two such mechanisms, frequently suggested to serve this goal are cellular quiescence, and non-random segregation of DNA strands duri

Externí odkaz: https://doaj.org/article/2e16d0539192401eb745f59f79f97b1c

Stem cell proliferation patterns as an alternative for in vivo prediction and discrimination of carcinogenic compounds

Autor: Jan-Pieter Ploem, Maxime Willems, Ellen Winckelmans, Michelle Plusquin, Tom Artois, Karen Smeets, An-Sofie Stevens

Publikováno v: Scientific Reports

One of the major challenges in the development of alternative carcinogenicity assays is the prediction of non-genotoxic carcinogens. The variety of non-genotoxic cancer pathways complicates the search for reliable parameters expressing their carcinog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f1b59242967c4d9a48216382e38241a
https://pubmed.ncbi.nlm.nih.gov/28466856

Toxicity profiles and solvent-toxicant interference in the planarianSchmidtea mediterraneaafter dimethylsulfoxide (DMSO) exposure

Autor: Nicky Pirotte, Maxime Willems, Karen Smeets, An-Sofie Stevens, Thomas Neyens, Michelle Plusquin, Tom Artois

Publikováno v: Journal of Applied Toxicology. 35:319-326

To investigate hydrophobic test compounds in toxicological studies, solvents like dimethylsulfoxide (DMSO) are inevitable. However, using these solvents, the interpretation of test compound-induced responses can be biased. DMSO concentration guidelin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a786da851e7179ec436edd3dc4d002e6
https://doi.org/10.1002/jat.3011

Redox-Related Mechanisms to Rebalance Cancer-Deregulated Cell Growth

Autor: Nicky Pirotte, Frank Van Belleghem, Andromeda Van Roten, Maxime Willems, Tom Artois, An-Sofie Stevens, Annelies Wouters, Ann Cuypers, Karen Smeets

Publikováno v: Stevens, A-S, Pirotte, N, Wouters, A, Van Roten, A, Van Belleghem, F, Willems, M, Cuypers, A, Artois, T & Smeets, K 2016, ' Redox-Related Mechanisms to Rebalance Cancer-Deregulated Cell Growth ', Current Drug Targets, vol. 17, no. 12, pp. 1414-1437 . https://doi.org/10.2174/1389450116666150506112817

A delicate balance exists between the process of carcinogenesis and tissue regeneration. A number of malignant tumours are considered the outcome of an impaired or incomplete regeneration process, resulting in persistently dividing cells. Regeneratio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c38ad526e2946766f70ee7a2f807d3b
https://hdl.handle.net/1820/1249b87b-0d55-4a53-823e-c1b9106ed971

Dual BrdU-PCNA immunodetection of proliferative cells in dental and orofacial tissues of teleosts

Autor: Ann Huysseune, Sam Vandenplas, Maxime Willems

Publikováno v: Journal of Applied Ichthyology. 28:336-340

Summary We have developed a protocol for simultaneous detection of BrdU and PCNA on paraffin sections of teleost tissues and have tested it successfully on dental and orofacial tissues of Atlantic salmon (Salmo salar) and zebrafish (Danio rerio). By

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3ed8ecb9decfb37e2fc7c3c318aa448a
https://doi.org/10.1111/j.1439-0426.2012.02003.x