Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Maxime W.C. Rousseaux"'
Publikováno v:
EBioMedicine, Vol 52, Iss , Pp - (2020)
Externí odkaz:
https://doaj.org/article/101d66f89c6d41d78739afe0e6d6e6e1
Progress toward an integrated understanding of Parkinson's disease [version 1; referees: 2 approved]
Publikováno v:
F1000Research, Vol 6 (2017)
Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease, affecting over 10 million individuals worldwide. While numerous effective symptomatic treatments are currently available, no curative or disease-
Externí odkaz:
https://doaj.org/article/8c2bc43a5c1a4f3aa92ad06a97cb8a6e
Autor:
Terry R. Suk, Trina T. Nguyen, Zoe A. Fisk, Miso Mitkovski, Haley M. Geertsma, Jean-Louis A. Parmasad, Meghan M. Heer, Steve M. Callaghan, Nils Brose, Marilyn Tirard, Maxime W.C. Rousseaux
Publikováno v:
bioRxiv
SUMOylation is an evolutionarily conserved and essential mechanism whereby Small Ubiquitin Like Modifiers, or SUMO proteins (Sumo in mice), are covalently bound to protein substrates in a highly dynamic and reversible manner. SUMOylation is involved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da0d0b3b17bab0dd3d7e8ba5f4db053d
https://doi.org/10.1101/2022.09.09.507035
https://doi.org/10.1101/2022.09.09.507035
Autor:
Liqiang Chen, Chetan Nagaraja, Samuel Daniels, Zoe A. Fisk, Rachel Dvorak, Lindsay Meyerdirk, Jennifer A Steiner, Martha L. Escobar Galvis, Michael X. Henderson, Maxime W.C. Rousseaux, Patrik Brundin, Hong-Yuan Chu
Publikováno v:
eLife. 11
The presynaptic protein α-synuclein (αSyn) has been suggested to be involved in the pathogenesis of Parkinson’s disease (PD). In PD, the amygdala is prone to develop insoluble αSyn aggregates, and it has been suggested that circuit dysfunction i
Autor:
Kyra Horsthuis, Konrad M. Ricke, Haley M. Geertsma, Zoe Fisk, Terry R. Suk, Maxime W.C. Rousseaux, Jean-Louis A. Parmasad, Steve M. Callaghan
BackgroundA growing body of evidence suggests that nuclear alpha-synuclein (αSyn) plays a role in the pathogenesis of Parkinson’s disease (PD). However, this question has been difficult to address as controlling the localization of αSyn in experi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c7abd24cf1ec676d82ee6b8a8fd599f
https://doi.org/10.1101/2021.10.13.464123
https://doi.org/10.1101/2021.10.13.464123
Autor:
Huda Y. Zoghbi, Juan Botas, Ismael Al-Ramahi, Sih Rong Wu, Samantha Mota, Carolyn J. Adamski, Hari Krishna Yalamanchili, Laura A. Lavery, Smruti Rath, Harry T. Orr, Youjin Jang, Shirin Soleimani, Zhandong Liu, Vitaliy V. Bondar, Maxime W.C. Rousseaux, Won Seok Lee, Wonho Kim, Ying Wooi Wan, Ambika Tewari, Eric B. Rutledge
Publikováno v:
EMBO J
A critical question in neurodegeneration is why the accumulation of disease-driving proteins causes selective neuronal loss despite their brain-wide expression. In Spinocerebellar ataxia type 1 (SCA1), accumulation of polyglutamine-expanded Ataxin-1
Autor:
Maxime W.C. Rousseaux, Terry R. Suk
Publikováno v:
Molecular Neurodegeneration
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-16 (2020)
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-16 (2020)
Since its discovery as a primary component in cytoplasmic aggregates in post-mortem tissue of patients with Amyotrophic Lateral Sclerosis (ALS), TAR DNA Binding Protein 43 kDa (TDP-43) has remained a central focus to understand the disease. TDP-43 li
Autor:
Aleksandar Bajić, Kristyn Gonzales, Gabriel E. Vázquez-Vélez, Jean-Pierre Revelli, Sabrina M. Heman-Ackah, Carolyn J. Adamski, Ronald Richman, Maxime W.C. Rousseaux, Evelyn Craigen, Fatemeh Alavi Naini, Matthew J.A. Wood, Huda Y. Zoghbi
Publikováno v:
J Neurosci
α-Synuclein (α-Syn) accumulation is a pathological hallmark of Parkinson's disease. Duplications and triplications ofSNCA, the gene coding for α-Syn, cause genetic forms of the disease, which suggests that increased α-Syn dosage can drive PD. To
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baa8e67680e871a6bb332ee727c4eff6
https://doi.org/10.1523/jneurosci.1076-19.2019
https://doi.org/10.1523/jneurosci.1076-19.2019
Autor:
Sung Yun Jung, Maxime W.C. Rousseaux, Yin Huang, Suman Maity, Yi Wang, Joachim Kutzera, Jean J. Kim, Huda Y. Zoghbi, Jong Min Choi, Jun Qin, Anna Malovannaya, Weimin Zhu
Publikováno v:
Molecular & Cellular Proteomics. 16:581-593
Here, we present a mouse brain protein atlas that covers 17 surgically distinct neuroanatomical regions of the adult mouse brain, each less than 1 mm3 in size. The protein expression levels are determined for 6,500 to 7,500 gene protein products from
Autor:
Shuang Hao, Antonia De Maio, Cristian A. Lasagna-Reeves, Jianrong Tang, Luis Vilanova-Velez, Huda Y. Zoghbi, Maxime W.C. Rousseaux, Lauren See, Jeehye Park, Zhenyu Wu, Juan C. Troncoso, Paymaan Jafar-Nejad, Thomas F. Westbrook, Maria de Haro, Larissa Nitschke, Juan Botas, Ismael Al-Ramahi
Publikováno v:
Neuron. 92:407-418
Many neurodegenerative proteinopathies share a common pathogenic mechanism: the abnormal accumulation of disease-related proteins. As growing evidence indicates that reducing the steady-state levels of disease-causing proteins mitigates neurodegenera