Dynamic microfluidic single-cell screening identifies pheno-tuning compounds to potentiate tuberculosis therapy

Autor: Maxime Mistretta, Mena Cimino, Pascal Campagne, Stevenn Volant, Etienne Kornobis, Olivier Hebert, Christophe Rochais, Patrick Dallemagne, Cédric Lecoutey, Camille Tisnerat, Alban Lepailleur, Yann Ayotte, Steven R. LaPlante, Nicolas Gangneux, Monika Záhorszká, Jana Korduláková, Sophie Vichier-Guerre, Frédéric Bonhomme, Laura Pokorny, Marvin Albert, Jean-Yves Tinevez, Giulia Manina

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)

Abstract Drug-recalcitrant infections are a leading global-health concern. Bacterial cells benefit from phenotypic variation, which can suggest effective antimicrobial strategies. However, probing phenotypic variation entails spatiotemporal analysis

Externí odkaz: https://doaj.org/article/fa9c75f3b4af4a52a3bae94cff9e5192

Characterization and analytical validation of a new antigenic rapid diagnostic test for Ebola virus disease detection.

Autor: Céline Couturier, Atsuhiko Wada, Karen Louis, Maxime Mistretta, Benoit Beitz, Moriba Povogui, Maryline Ripaux, Charlotte Mignon, Bettina Werle, Adrien Lugari, Delphine Pannetier, Sabine Godard, Anne Bocquin, Stéphane Mely, Ismaël Béavogui, Jean Hébélamou, David Leuenberger, Philippe Leissner, Takeshi Yamamoto, Patrick Lécine, Christophe Védrine, Julie Chaix

Publikováno v: PLoS Neglected Tropical Diseases, Vol 14, Iss 1, p e0007965 (2020)

Hemorrhagic fever outbreaks are difficult to diagnose and control in part because of a lack of low-cost and easily accessible diagnostic structures in countries where etiologic agents are present. Furthermore, initial clinical symptoms are common and

Externí odkaz: https://doaj.org/article/a32d69d0fa0244148a115c6b8ed277fd

Dynamics of drug response in single mycobacterial cells by microfluidic dose-response assay

Autor: Maxime Mistretta, Nicolas Gangneux, Giulia Manina

Preclinical analysis of drug efficacy is critical for drug development. However, conventional bulk-cell assays statically assess the mean population behavior, lacking resolution on drugescaping cells. Inaccurate estimation of efficacy can lead to ove

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2dc1ba27c103bcae535956425cf0a7c
https://doi.org/10.1101/2022.04.03.486879

Characterization and analytical validation of a new antigenic rapid diagnostic test for Ebola virus disease detection

Autor: Julie Chaix, Stéphane Mély, Adrien Lugari, Atsuhiko Wada, Philippe Leissner, Karen Louis, Maxime Mistretta, Takeshi Yamamoto, Moriba Povogui, Céline Couturier, Maryline Ripaux, Sabine Godard, Jean Hébélamou, Delphine Pannetier, Charlotte Mignon, Anne Bocquin, Christophe Védrine, Patrick Lécine, Benoit Beitz, Bettina Werle, David Leuenberger, Ismaël Béavogui

Publikováno v: PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Public Library of Science, 2020, 14 (1), pp.e0007965. ⟨10.1371/journal.pntd.0007965⟩
PLoS Neglected Tropical Diseases, Vol 14, Iss 1, p e0007965 (2020)

Hemorrhagic fever outbreaks are difficult to diagnose and control in part because of a lack of low-cost and easily accessible diagnostic structures in countries where etiologic agents are present. Furthermore, initial clinical symptoms are common and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35b09801172071ae8a4d8b787e258cb7
http://europepmc.org/articles/PMC6992227

Thermal and hyperspectral imaging for Norway spruce (Picea abies) seeds screening

Autor: Markku Keinänen, Sarita Keski-Saari, Markku Nygren, Laure Fauch, Tapani Hirvonen, Lars Granlund, Ilkka Porali, Katri Himanen, Elina Oksanen, Markku Hauta-Kasari, Jennifer Dumont, Jouni Hiltunen, Maxime Mistretta, Ville Heikkinen

Publikováno v: Computers and Electronics in Agriculture. 116:118-124

Hyperspectral and thermal lifetime imaging were used to assess spruce seed quality.Viable, empty and infested seeds were resolved with high accuracy with both methods.400-1000nm data was not as informative as 1000-2500nm and thermal decay data.Classi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f5482ef04b67c51e4d9416f7968f912f
https://doi.org/10.1016/j.compag.2015.06.010