Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Maxime Melikian"'
Publikováno v:
Journal of Chemical Information and Modeling. 57:223-233
NF-κB is a major transcription factor whose activation is triggered through two main activation pathways: the canonical pathway involving disruption of IκB-α/NF-κB complexes and the alternative pathway whose activation relies on the inducible pro
Autor:
Nils Sorgenfrei, Matej Žabka, Johannes Gramüller, Ruth M. Gschwind, Julian Greindl, Fabio Morana, Maxime Melikian, Johnny Hioe, Thomas Hausler, Kerstin Rothermel
Publikováno v:
Chemical Science
NMR H-bond analysis reveals an offset of internal and external acidities of catalysts and allows for a detailed reactivity analysis.
The concept of hydrogen bonding for enhancing substrate binding and controlling selectivity and reactivity is ce
The concept of hydrogen bonding for enhancing substrate binding and controlling selectivity and reactivity is ce
Publikováno v:
Chemical Science
Advanced NMR and theoretical studies reveal detailed insights into monomeric and dimeric structures plus deviating experimental and theoretical E/Z-populations.
BINOL derived chiral phosphoric acids (CPAs) are widely known for their high selecti
BINOL derived chiral phosphoric acids (CPAs) are widely known for their high selecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cd6899972d941628044f565faec3d8d
https://epub.uni-regensburg.de/48656/
https://epub.uni-regensburg.de/48656/
Autor:
Maxime Melikian, Claudio Luchinat, Gregg B. Fields, Ivano Bertini, Mirco Toccafondi, Marco Fragai, Janelle L. Lauer
Publikováno v:
Journal of the American Chemical Society; Vol 134
The proteolysis of collagen triple-helical structure (collagenolysis) is a poorly understood yet critical physiological process. Presently, matrix metalloproteinase 1 (MMP-1) and collagen triple-helical peptide models have been utilized to characteri
Publikováno v:
Chemistry - A European Journal. 15:7842-7845
Autor:
Dmitri I. Svergun, Efstratios Mylonas, Marco Fragai, Vito Calderone, Maxime Melikian, Claudio Luchinat, Rahul Jaiswal, Ivano Bertini
Publikováno v:
Journal of the American Chemical Society. 130:7011-7021
The proteolytic activity of matrix metalloproteinases toward extracellular matrix components (ECM), cytokines, chemokines, and membrane receptors is crucial for several homeostatic and pathological processes. Active MMPs are a family of single-chain
Autor:
Maxime Melikian, Chengsen Xue, J.W. Chiao, Luxi Wang, Liying Han, Karim Solangi, Allen Tsao, John T. Fallon, Gildas Bertho, Long G. Wang, Simon Mencher
Publikováno v:
Biochemical pharmacology. 99
A small molecule, Natura-α, a clinical stage investigational new drug for certain inflammatory diseases, has been evaluated for drug interaction with STAT3 and inhibiting systemic lupus erythematosus (SLE). Studies have revealed that it selectively
Autor:
Sonia Beltran, Nadia Walchshofer, Marc Le Borgne, Roland Barret, Agnès Emptoz-Bonneton, Charles Dumontet, Michel Pugeat, Catherine Grenot, Zahia Mahiout, Maxime Melikian, Eva-Laure Matera, Lucienne El Jawad, Ghina Alameh, Elisabeth Mappus, Luc Rocheblave, Marc Rolland de Ravel, Claude Yves Cuilleron, Thierry Lomberget
Publikováno v:
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2015, 58 (4), pp.1832-1845. ⟨10.1021/jm501676v⟩
Journal of Medicinal Chemistry, American Chemical Society, 2015, 58 (4), pp.1832-1845. ⟨10.1021/jm501676v⟩
A simple route for improving the potency of progesterone as a modulator of P-gp-mediated multidrug resistance was established by esterification or etherification of hydroxylated 5α/β-pregnane-3,20-dione or 5β-cholan-3-one precursors. X-ray crystal
Autor:
Marco Fragai, Maxime Melikian, Ivano Bertini, Dmitri I. Svergun, Efstratios Mylonas, Claudio Luchinat, Niko Sarti
The presence of extensive reciprocal conformational freedom between the catalytic and the hemopexin-like domains of full-length matrix metalloproteinase-1 (MMP-1) is demonstrated by NMR and small angle x-ray scattering experiments. This finding is di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b26495a9121ca9b0e03a0905c2c2377
https://europepmc.org/articles/PMC2676012/
https://europepmc.org/articles/PMC2676012/