Synthesis and Promising in Vitro Antiproliferative Activity of Sulfones of a 5-Nitrothiazole Series

Autor: Nadine Azas, Patrice Vanelle, Pascal Rathelot, Maxime D. Crozet, Anita Cohen

Publikováno v: Molecules, Vol 18, Iss 1, Pp 97-113 (2012)

The synthesis in water of new sulfone derivatives under microwave irradiation is described. This eco-friendly process leads to the expected products in good yields by reaction of various substituted sulfinates (commercially available or obtained by r

Externí odkaz: https://doaj.org/article/70612332165143dfaa5d96856639872c

Synthesis of New Potentially Bioactive Bicyclic 2-Pyridones

Autor: Patrice Vanelle, Michel P. Crozet, Pascal George, Maxime D. Crozet

Publikováno v: Molecules, Vol 10, Iss 10, Pp 1318-1324 (2005)

Three convenient methods of reduction of the nitro group of 5-nitroimidazoles and 5-nitrothiazole that bear a diethylmethylene malonate group in an ortho-like position with respect to the nitro group and cyclization of the resulting amino derivatives

Externí odkaz: https://doaj.org/article/633127a3accf411c9fd903fe3683b334

An Efficient One-Pot Catalyzed Synthesis of 2,4-Disubstituted 5-Nitroimidazoles Displaying Antiparasitic and Antibacterial Activities

Autor: Fanny Mathias, Youssef Kabri, Liliane Okdah, Carole Di Giorgio, Jean-Marc Rolain, Cédric Spitz, Maxime D. Crozet, Patrice Vanelle

Publikováno v: Molecules, Vol 22, Iss 8, p 1278 (2017)

A one-pot regioselective bis-Suzuki-Miyaura or Suzuki-Miyaura/Sonogashira reaction on 2,4-dibromo-1-methyl-5-nitro-1H-imidazole under microwave heating was developed. This method is applicable to a wide range of (hetero)arylboronic acids and terminal

Externí odkaz: https://doaj.org/article/1bcd6bd329f644ee95a9910850e9da80

Efficient Access to Original 6-Substituted 5-Nitro-2,3-dihydro­imidazo[2,1-b]oxazoles

Autor: Fanny Mathias, Patrice Vanelle, Maxime D. Crozet, Youssef Kabri

Publikováno v: Synthesis. 49:2775-2785

A one-pot sequential intramolecular cyclization and Suzuki–Miyaura or Sonogashira reaction under microwave irradiation are reported in the 5-nitro-2,3-dihydroimidazo[2,1-b]oxazole series. The intramolecular cyclization of 1-(2,4-dibromo-5-nitro-1H-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::84a0f374860ff985818089d2068a35a0
https://doi.org/10.1055/s-0036-1588984

Synthesis of new substituted imidazo[1,2-a]pyridinylpropenenitriles through sequential one-pot Suzuki–Miyaura/Knoevenagel reactions in aqueous medium

Autor: Bellara Nedjar-Kolli, Saléha Bakhta, Patrice Vanelle, Maxime D. Crozet, Youssef Kabri

Publikováno v: Synthetic Communications
Synthetic Communications, Taylor & Francis: STM, Behavioural Science and Public Health Titles, 2019, 49 (19), pp.2561--2571. ⟨10.1080/00397911.2019.1634213⟩
Synthetic Communications, 2019, 49 (19), pp.2561--2571. ⟨10.1080/00397911.2019.1634213⟩

WOS:000475040300001; A series of imidazo[1,2-a]pyridinylpropenenitriles were synthesized via consecutive one-pot Suzuki-Miyaura and Knoevenagel reactions in water/ethanol mixture between imidazo[1,2-a]pyridine-2-carbaldehydes, arylboronic acids and m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73e84fd94194b09592937231e72d4e2c