Homodimerization as a molecular switch between low and high efficiency PrPCcell surface delivery and neuroprotective activity

Autor: Maxime Béland, Xavier Roucou

Publikováno v: Prion. 7:170-174

PrP (C) is associated with a variety of functions, and its ability to interact with a multitude of partners, including itself, may largely explain PrP multifunctionality and the lack of consensus on the genuine physiological function of the protein i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da8b463dd25144cd59c4c34b7effd49a
https://doi.org/10.4161/pri.23583

Escherichia coli O157:H7 Survives within Human Macrophages: Global Gene Expression Profile and Involvement of the Shiga Toxins

Autor: Sébastien P. Faucher, Victor P. J. Gannon, Maxime Béland, Josée Harel, Katherine Poirier, Christine Martin, Roland Brousseau

Publikováno v: Infection and Immunity. 76:4814-4822

Escherichia coli O157:H7 is an important food-borne pathogen that specifically binds to the follicle-associated epithelium in the intestine, which rapidly brings this bacterial pathogen in contact with underlying human macrophages. Very little inform

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f104f95e48c34d9d1e6c3cc13f64c99c
https://doi.org/10.1128/iai.00446-08

Aβ induces its own prion protein N-terminal fragment (PrPN1)-mediated neutralization in amorphous aggregates

Autor: Guillaume Tremblay, Mikaël Bédard, Pierre Lavigne, Xavier Roucou, Maxime Béland

Publikováno v: Neurobiology of aging. 35(7)

Plasma membrane cellular prion protein (PrP C ) is a high-affinity receptor for toxic soluble amyloid-β (Aβ) oligomers that mediates synaptic dysfunction. Secreted forms of PrP C resulting from PrP C α-cleavage (PrPN1) or shedding (shed PrP C ) di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39a4973ebd0637253b33c8884b09b17d
https://pubmed.ncbi.nlm.nih.gov/24602510

Proteomics-based confirmation of protein expression and correction of annotation errors in the Brucella abortus genome

Autor: Julie Lamontagne, Najib Nassif, Maxime Béland, Fadi Tomaki, Ignacio Moriyón, Anik Forest, Eustache Paramithiotis, Alexandra Côté-Martin, Edgardo Moreno

Publikováno v: BMC Genomics, Vol 11, Iss 1, p 300 (2010)
Dadun. Depósito Académico Digital de la Universidad de Navarra
instname
BMC Genomics

Background Brucellosis is a major bacterial zoonosis affecting domestic livestock and wild mammals, as well as humans around the globe. While conducting proteomics studies to better understand Brucella abortus virulence, we consolidated the proteomic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01c2c6631889dfca53e3fff6935e5a4c
http://www.biomedcentral.com/1471-2164/11/300

The presence of the tet gene from cloning vectors impairs Salmonella survival in macrophages

Autor: Roy Curtiss, Sébastien P. Faucher, Stephanie Abromaitis, Maxime Béland

Publikováno v: FEMS microbiology letters. 242(2)

Cloning, mutagenesis and complementation of virulence factors are key steps to understand the mechanisms of bacterial pathogenesis and cloning vectors are routinely utilized for these processes. We have investigated the effect of the presence of comm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30e422c0d6f37e2f3cbdd1a45a07eb19
https://pubmed.ncbi.nlm.nih.gov/15621452