Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Maxime, Tarabichi"'
Autor:
Evit John, Tom Lesluyes, Toby M. Baker, Maxime Tarabichi, Ann Gillenwater, Jennifer R. Wang, Peter Van Loo, Xiao Zhao
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Oral potentially malignant disorders (OPMDs) with genomic alterations have a heightened risk of evolving into oral squamous cell carcinoma (OSCC). Currently, genomic data are typically obtained through invasive tissue biopsy. However, brush
Externí odkaz:
https://doaj.org/article/3d87769b4f7742228caa5e2658ad40fa
Autor:
Sabine Paternot, Eric Raspé, Clément Meiller, Maxime Tarabichi, Jean‐Baptiste Assié, Frederick Libert, Myriam Remmelink, Xavier Bisteau, Patrick Pauwels, Yuna Blum, Nolwenn Le Stang, Séverine Tabone‐Eglinger, Françoise Galateau‐Sallé, Christophe Blanquart, Jan P. Van Meerbeeck, Thierry Berghmans, Didier Jean, Pierre P. Roger
Publikováno v:
Molecular Oncology, Vol 18, Iss 4, Pp 866-894 (2024)
Malignant pleural mesothelioma (MPM) is an aggressive cancer with limited therapeutic options. We evaluated the impact of CDK4/6 inhibition by palbociclib in 28 MPM cell lines including 19 patient‐derived ones, using various approaches including RN
Externí odkaz:
https://doaj.org/article/72b5f65e65c1467eb0155ad0c9eabfb4
Autor:
Jaime M. Pita, Eric Raspé, Katia Coulonval, Myriam Decaussin-Petrucci, Maxime Tarabichi, Geneviève Dom, Frederick Libert, Ligia Craciun, Guy Andry, Laurence Wicquart, Emmanuelle Leteurtre, Christophe Trésallet, Laura A. Marlow, John A. Copland, Cosimo Durante, Carine Maenhaut, Branca M. Cavaco, Jacques E. Dumont, Giuseppe Costante, Pierre P. Roger
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
BackgroundCDK4/6 inhibitors (CDK4/6i) have been established as standard treatment against advanced Estrogen Receptor-positive breast cancers. These drugs are being tested against several cancers, including in combinations with other therapies. We ide
Externí odkaz:
https://doaj.org/article/6abad13998f7473bad18f0d24f04952e
Autor:
Tom L. Kaufmann, Marina Petkovic, Thomas B. K. Watkins, Emma C. Colliver, Sofya Laskina, Nisha Thapa, Darlan C. Minussi, Nicholas Navin, Charles Swanton, Peter Van Loo, Kerstin Haase, Maxime Tarabichi, Roland F. Schwarz
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-27 (2022)
Abstract Aneuploidy, chromosomal instability, somatic copy-number alterations, and whole-genome doubling (WGD) play key roles in cancer evolution and provide information for the complex task of phylogenetic inference. We present MEDICC2, a method for
Externí odkaz:
https://doaj.org/article/e4b330fa56874857bbfdc7ede9300d31
Autor:
Georgia Zoumpoulidou, Carlos Alvarez-Mendoza, Caterina Mancusi, Ritika-Mahmuda Ahmed, Milly Denman, Christopher D. Steele, Maxime Tarabichi, Errin Roy, Lauren R. Davies, Jiten Manji, Camilla Cristalli, Katia Scotlandi, Nischalan Pillay, Sandra J. Strauss, Sibylle Mittnacht
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
RB1 mutations are seen in 40-60% of sporadic osteosarcoma. Here, the authors demonstrate a selective sensitivity to PARP inhibitors in RB1-mutated osteosarcoma-derived cell lines that is not associated with canonical signatures indicative of a homolo
Externí odkaz:
https://doaj.org/article/29d2b65339524853a5548dbf68b35ca4
Autor:
Maria Xydia, Raheleh Rahbari, Eliana Ruggiero, Iain Macaulay, Maxime Tarabichi, Robert Lohmayer, Stefan Wilkening, Tillmann Michels, Daniel Brown, Sebastiaan Vanuytven, Svetlana Mastitskaya, Sean Laidlaw, Niels Grabe, Maria Pritsch, Raffaele Fronza, Klaus Hexel, Steffen Schmitt, Michael Müller-Steinhardt, Niels Halama, Christoph Domschke, Manfred Schmidt, Christof von Kalle, Florian Schütz, Thierry Voet, Philipp Beckhove
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
The mechanisms that shape the regulatory T cell repertoire in patients with cancer are not completely understood. Here, the authors observe that, in breast cancer patients, tumor-resident regulatory T cells do not show clonal relationship with their
Externí odkaz:
https://doaj.org/article/564548dac492461fa165fbbe611c1237
Autor:
Diego Perez-Rodriguez, Maria Kalyva, Melissa Leija-Salazar, Tammaryn Lashley, Maxime Tarabichi, Viorica Chelban, Steve Gentleman, Lucia Schottlaender, Hannah Franklin, George Vasmatzis, Henry Houlden, Anthony H. V. Schapira, Thomas T. Warner, Janice L. Holton, Zane Jaunmuktane, Christos Proukakis
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-22 (2019)
Abstract Synucleinopathies are mostly sporadic neurodegenerative disorders of partly unexplained aetiology, and include Parkinson’s disease (PD) and multiple system atrophy (MSA). We have further investigated our recent finding of somatic SNCA (α-
Externí odkaz:
https://doaj.org/article/7ef14b0631654f92929d5d083479b9c2
Autor:
Matthew W. Fittall, William Mifsud, Nischalan Pillay, Hongtao Ye, Anna-Christina Strobl, Annelien Verfaillie, Jonas Demeulemeester, Lei Zhang, Fitim Berisha, Maxime Tarabichi, Matthew D. Young, Elena Miranda, Patrick S. Tarpey, Roberto Tirabosco, Fernanda Amary, Agamemnon E. Grigoriadis, Michael R. Stratton, Peter Van Loo, Cristina R. Antonescu, Peter J. Campbell, Adrienne M. Flanagan, Sam Behjati
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-6 (2018)
FOS has been linked to bone tumour pathogenesis, and viral homologue v-fos causes osteosarcoma in mice. Here, the authors report rearrangement of FOS and its paralogue FOSB in osteoblastoma and osteoid osteoma, revealing human bone tumours that are d
Externí odkaz:
https://doaj.org/article/e874f5cac91c4dfcb8f739743873d777
Autor:
Ruben M. Drews, Barbara Hernando, Maxime Tarabichi, Kerstin Haase, Tom Lesluyes, Philip S. Smith, Lena Morrill Gavarró, Dominique-Laurent Couturier, Lydia Liu, Michael Schneider, James D. Brenton, Peter Van Loo, Geoff Macintyre, Florian Markowetz
Publikováno v:
Nature
Chromosomal instability (CIN) results in the accumulation of large-scale losses, gains, and rearrangements of DNA(1). The broad genomic complexity caused by CIN is a hallmark of cancer(2), however, there is no systematic framework to measure differen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b195b1ee3534ba28f939f59096c916b6
https://doi.org/10.1038/s41586-022-04789-9
https://doi.org/10.1038/s41586-022-04789-9
Autor:
Christopher D. Steele, Ammal Abbasi, S. M. Ashiqul Islam, Amy L. Bowes, Azhar Khandekar, Kerstin Haase, Shadi Hames-Fathi, Dolapo Ajayi, Annelien Verfaillie, Pawan Dhami, Alex McLatchie, Matt Lechner, Nicholas Light, Adam Shlien, David Malkin, Andrew Feber, Paula Proszek, Tom Lesluyes, Fredrik Mertens, Adrienne M. Flanagan, Maxime Tarabichi, Peter Van Loo, Ludmil B. Alexandrov, Nischalan Pillay
Publikováno v:
Nature. 606:984-991
Gains and losses of DNA are prevalent in cancer and emerge as a consequence of inter-related processes of replication stress, mitotic errors, spindle multipolarity and breakage–fusion–bridge cycles, among others, which may lead to chromosomal ins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a02d9521457a90bfa20c8587aaa1a93
https://doi.org/10.1038/s41586-022-04738-6
https://doi.org/10.1038/s41586-022-04738-6