Výsledky vyhledávání - "Maxim Verstraeten"

Impact of material properties and process variables on the residence time distribution in twin screw feeding equipment

Autor: T. De Beer, Valérie Vanhoorne, Jens Dhondt, Chris Vervaet, Maxim Verstraeten, Ashish Kumar, B. Van Snick, G. Di Pretoro, Kenny Pandelaere

Publikováno v: International Journal of Pharmaceutics. 556:200-216

Screw feeders are integrated as dispensing units in most continuous manufacturing platforms. Hence, characterizing and modelling the residence time distribution (RTD) of materials in feeders is indispensable to understand the traceability of raw mate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b165edc1f24061875aacf49ca493702
https://doi.org/10.1016/j.ijpharm.2018.11.076

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On the modelling of granule size distributions in twin-screw wet granulation: Calibration of a novel compartmental population balance model

Autor: Daan Van Hauwermeiren, Thomas De Beer, Ingmar Nopens, Kai Lee, Maxim Verstraeten, Mary T. am Ende, Pankaj Doshi, Neil Turnbull

Publikováno v: Powder Technology. 341:116-125

In recent years, novel developments in the continuous manufacturing of solid dosage forms using twin-screw wet granulation have grasped the attention of the pharmaceutical industry. In spite of this progress, there still exists a lack of fundamental

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7fd2b439fe65dc6e53d1ddd677191c05
https://doi.org/10.1016/j.powtec.2018.05.025

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Model development and prediction of particle size distribution, density and friability of a comilling operation in a continuous pharmaceutical manufacturing process

Autor: Ivo Van Assche, Ravendra Singh, Nirupaplava Metta, Elisabeth Schäfer, Rohit Ramachandran, Maxim Verstraeten, Michael Ghijs, Thomas De Beer, Marianthi G. Ierapetritou, Philippe Cappuyns, Ingmar Nopens, Ashish Kumar

Publikováno v: International journal of pharmaceutics. 549(1-2)

The comilling process plays an important role in solid oral dosage manufacturing. In this process, the granulated products are comminuted to the required size distribution through collisions created from a rotating impeller. In addition to predicting

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::707516100feeaeec559d6fe83acd6a83
https://pubmed.ncbi.nlm.nih.gov/30076889

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Model-based NIR spectroscopy implementation for in-line assay monitoring during a pharmaceutical suspension manufacturing process

Autor: Eline Hermans, Jeroen Geens, Mario Hellings, Maxim Verstraeten, Daan Van Hauwermeiren, Chris Vervaet, Ingmar Nopens, Thomas De Beer

Publikováno v: International journal of pharmaceutics. 546(1-2)

The implementation of Process Analytical Technology (PAT) instruments is generally achieved stochastically. Sub-optimal PAT locations could introduce variation in the measurements which is not related to the analyte of interest. For this reason, rati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b71ed8f53b90c65f9fe1e5c98a4f1ee
https://pubmed.ncbi.nlm.nih.gov/29792986

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In-depth experimental analysis of pharmaceutical twin-screw wet granulation in view of detailed process understanding

Autor: Chris Vervaet, Daan Van Hauwermeiren, Thomas De Beer, Mary T. am Ende, Neil Turnbull, Davinia Brouckaert, Kai Lee, Maxim Verstraeten, Pankaj Doshi, David Wilsdon, Séverine Thérèse F.C. Mortier, Ingmar Nopens

Publikováno v: International journal of pharmaceutics. 529(1-2)

Twin-screw wet granulation is gaining increasing interest within the pharmaceutical industry for the continuous manufacturing of solid oral dosage forms. However, limited prior fundamental physical understanding has been generated relating to the gra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9929e0464932cfaa2084e7ab019b2e4
https://pubmed.ncbi.nlm.nih.gov/28720539

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Multivariate statistical process control of a continuous pharmaceutical twin-screw granulation and fluid bed drying process

Autor: J.P. Remon, Jurgen Vercruysse, Mafalda C. Sarraguça, João A. Lopes, Ana Filipa Silva, N. Bostijn, F. De Leersnyder, Chris Vervaet, T. De Beer, Maxim Verstraeten, Margot Fonteyne, Valérie Vanhoorne

Publikováno v: International journal of pharmaceutics. 528(1-2)

A multivariate statistical process control (MSPC) strategy was developed for the monitoring of the ConsiGma™-25 continuous tablet manufacturing line. Thirty-five logged variables encompassing three major units, being a twin screw high shear granula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26f4d9e90cc41d1464eec265902e0830
https://pubmed.ncbi.nlm.nih.gov/28583334

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Methodology and Pitfalls when Calibrating a PBM: the Case of Twin-Screw Wet Granulation

Autor: Thomas De Beer, Daan Van Hauwermeiren, Ingmar Nopens, Maxim Verstraeten

Publikováno v: Granulation, 8th International workshop, Papers

Traditional pharmaceutical processes comprise of a series of batch-wise operations. Nowadays, a shift is being made from these batch processes to continuous manufacturing, to cope with the inefficiencies and high cost involved in process development

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2994051f00cd1ecb43a45867d080631e
https://doi.org/10.1016/b978-0-444-63965-3.50009-x

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