Zobrazeno 1 - 10
of 242
pro vyhledávání: '"Maxim Sorokin"'
Autor:
Maxim Sorokin, Marianna Zolotovskaia, Daniil Nikitin, Maria Suntsova, Elena Poddubskaya, Alexander Glusker, Andrew Garazha, Alexey Moisseev, Xinmin Li, Marina Sekacheva, David Naskhletashvili, Alexander Seryakov, Ye Wang, Anton Buzdin
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-19 (2022)
Abstract Background: Overall survival of advanced colorectal cancer (CRC) patients remains poor, and gene expression analysis could potentially complement detection of clinically relevant mutations to personalize CRC treatments. Methods: We performed
Externí odkaz:
https://doaj.org/article/f0e65dd2612144beba125d5e02bdbed1
Autor:
Nicolas Borisov, Victor Tkachev, Alexander Simonov, Maxim Sorokin, Ella Kim, Denis Kuzmin, Betul Karademir-Yilmaz, Anton Buzdin
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Introduction: Co-normalization of RNA profiles obtained using different experimental platforms and protocols opens avenue for comprehensive comparison of relevant features like differentially expressed genes associated with disease. Currently, most o
Externí odkaz:
https://doaj.org/article/bc9b1b45fed6475d95b7a77ee28fe063
Autor:
Olga Kovaleva, Maxim Sorokin, Anastasija Egorova, Anatoly Petrenko, Ksenya Shelekhova, Alexei Gratchev
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Tumor cells communication with tumor associated macrophages is a highly important factor of tumor malignant potential development. For a long time, studies of this interaction were focused on a cytokine- and other soluble factors -mediated processes.
Externí odkaz:
https://doaj.org/article/2c8279c7e5a0447c9a2b55ca1bd43825
Autor:
Marianna Zolotovskaia, Maks Kovalenko, Polina Pugacheva, Victor Tkachev, Alexander Simonov, Maxim Sorokin, Alexander Seryakov, Andrew Garazha, Nurshat Gaifullin, Marina Sekacheva, Galina Zakharova, Anton A. Buzdin
Publikováno v:
Proteomes, Vol 11, Iss 3, p 26 (2023)
Individual gene expression and molecular pathway activation profiles were shown to be effective biomarkers in many cancers. Here, we used the human interactome model to algorithmically build 7470 molecular pathways centered around individual gene pro
Externí odkaz:
https://doaj.org/article/ad117488a3bc4345bdbae550b0a3ed52
Publikováno v:
BMC Medical Genomics, Vol 13, Iss S8, Pp 1-9 (2020)
Abstract Background Machine learning (ML) methods still have limited applicability in personalized oncology due to low numbers of available clinically annotated molecular profiles. This doesn’t allow sufficient training of ML classifiers that could
Externí odkaz:
https://doaj.org/article/1823df67775841159d7cb328193e7cd0
Autor:
Nikolay Konovalov, Stanislav Timonin, Dmitry Asyutin, Mikhail Raevskiy, Maxim Sorokin, Anton Buzdin, Stanislav Kaprovoy
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
In this study, we report 31 spinal intramedullary astrocytoma (SIA) RNA sequencing (RNA-seq) profiles for 25 adult patients with documented clinical annotations. To our knowledge, this is the first clinically annotated RNA-seq dataset of spinal astro
Externí odkaz:
https://doaj.org/article/273105fe728a47068d78edf2511d482d
Autor:
Maxim Sorokin, Alexander Gorelyshev, Victor Efimov, Evgenia Zotova, Marianna Zolotovskaia, Elizaveta Rabushko, Denis Kuzmin, Alexander Seryakov, Dmitry Kamashev, Xinmin Li, Elena Poddubskaya, Maria Suntsova, Anton Buzdin
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Tumor mutation burden (TMB) is a well-known efficacy predictor for checkpoint inhibitor immunotherapies. Currently, TMB assessment relies on DNA sequencing data. Gene expression profiling by RNA sequencing (RNAseq) is another type of analysis that ca
Externí odkaz:
https://doaj.org/article/3accc6fa25814229934dc84dbeba498f
Autor:
Alexander Seryakov, Zaynab Magomedova, Maria Suntsova, Anastasia Prokofieva, Elizaveta Rabushko, Alexander Glusker, Lyudmila Makovskaia, Marianna Zolotovskaia, Anton Buzdin, Maxim Sorokin
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Uterine leiomyosarcoma (UL) is a rare malignant tumor that develops from the uterine smooth muscle tissue. Due to the low frequency and lack of sufficient data from clinical trials there is currently no effective treatment that is routinely accepted
Externí odkaz:
https://doaj.org/article/45b634a9f6574fda8cb58a10d2a45069
Autor:
Nicolas Borisov, Irina Shabalina, Victor Tkachev, Maxim Sorokin, Andrew Garazha, Andrey Pulin, Ilya I. Eremin, Anton Buzdin
Publikováno v:
BMC Bioinformatics, Vol 20, Iss 1, Pp 1-10 (2019)
Abstract Background Harmonization techniques make different gene expression profiles and their sets compatible and ready for comparisons. Here we present a new bioinformatic tool termed Shambhala for harmonization of multiple human gene expression da
Externí odkaz:
https://doaj.org/article/5eecde675783479d9739b2c4756b0a22
Autor:
Elizaveta Rabushko, Maxim Sorokin, Maria Suntsova, Alexander P. Seryakov, Denis V. Kuzmin, Elena Poddubskaya, Anton A. Buzdin
Publikováno v:
Biomedicines, Vol 10, Iss 8, p 1866 (2022)
Drugs targeting receptor tyrosine kinase (RTK) oncogenic fusion proteins demonstrate impressive anti-cancer activities. The fusion presence in the cancer is the respective drug prescription biomarker, but their identification is challenging as both t
Externí odkaz:
https://doaj.org/article/b0c9fe5046ff4fc99785f002536ab0b9