Výsledky vyhledávání - "Maxim S. Kobzev"

Akademický článek

Unusual thermolysis of azacyclic allene under microwave conditions: crystal structure of (3RS,3aSR,8RS,8aRS)-methyl 5,6-dimethoxy-3a,10-dimethyl-1-phenyl-3,3a,8,8a-tetrahydro-3,8-(epiminomethano)cyclopenta[a]indene-2-carboxylate from synchrotron X-ray diffraction

Autor: Le Tuan Anh, Alexander A. Titov, Maxim S. Kobzev, Leonid G. Voskressensky, Alexey V. Varlamov, Pavel V. Dorovatovskii, Victor N. Khrustalev

Publikováno v: Acta Crystallographica Section E: Crystallographic Communications, Vol 73, Iss 11, Pp 1770-1773 (2017)

The title compound, C25H27NO4 (I), the product of the unusual thermolysis of azacyclic allene methyl 10,11-dimethoxy-3,8-dimethyl-6-phenyl-3-azabenzo[d]cyclodeca-4,6,7-triene-5-carboxylate, represents a bicyclic heterosystem and crystallizes in the m

Externí odkaz: https://doaj.org/article/ad10104466624936b98bede4136ade89

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Synthesis of 8-phenyl substituted 3-benzazecines with allene moiety, their thermal rearrangement and evaluation as acetylcholinesterase inhibitors

Autor: Marco Catto, Rosa Purgatorio, Maxim S. Kobzev, Alexander A. Titov, Elena A. Sorokina, Tatiana N. Borisova, Leonid G. Voskressensky, Elena V. Alexandrova, Alexey V. Varlamov, Cosimo Altomare

Publikováno v: Molecular Diversity. 26:1243-1247

Various 4′-R-substituted phenyl azacyclic allenes were synthesized in good yields, and their thermal transformations were studied. For the first time, the obtained rearrangement products—new N-bridged cyclopenta[a]indenes, and the corresponding p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::35648538934a8901057630462084de1e
https://doi.org/10.1007/s11030-021-10185-8

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Away from Flatness: Unprecedented Nitrogen-Bridged Cyclopenta[a]indene Derivatives as Novel Anti-Alzheimer Multitarget Agents

Autor: Cosimo Altomare, Alexander A. Titov, Tatiana N. Borisova, Nunzio Denora, Leonid G. Voskressensky, Nicola Gambacorta, Marco Catto, Leonardo Pisani, Modesto de Candia, Alexey V. Varlamov, Orazio Nicolotti, Maxim S. Kobzev

Publikováno v: ACS Chemical Neuroscience. 12:340-353

Nature-inspired, bridged polycyclic molecules share low similarity with currently available drugs, containing preferentially planar and/or achiral moieties. This "Escape from Flatland" scenario, aimed at exploring pharmacological properties of atypic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::83246f0780cd37d6babafad28460335f
https://doi.org/10.1021/acschemneuro.0c00706

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Unusual Transformations of Cyclic Allenes with an Enamine Moiety into Complex Frameworks

Autor: Leonid G. Voskressensky, Erik V. Van der Eycken, Elena A. Sorokina, Alexey V. Varlamov, Maxim S. Kobzev, Alexander A. Titov, Tatiana N. Borisova

Publikováno v: Synlett. 31:672-676

The thermolysis reactions of benzoazacyclodecatrienes under microwave irradiation conditions in toluene at 150 °C afforded complex azabenzo[a]cyclopropa[cd]azulene and (epiminomethano)cyclopenta[a]indene frameworks. Cyclopropanes were established as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::88afe0b77fe081eab7bbe4868af2e51d
https://doi.org/10.1055/s-0039-1691586

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Switchable light vs. acid-induced transformations of complex framework compounds at room temperature

Autor: Maxim S. Kobzev, Alexander A. Titov, Tatiana N. Borisova, Leonid G. Voskressensky, Alexey V. Varlamov, Massimo Christian D'Alterio, Alessio Petrone, Rafael Luque, Giovanni Talarico

A novel and original protocol for the preparation of complex framework compounds containing a vinylcyclopropane (VCP) fragment is presented by means of UV conversion of cyclopentene (CP) derivatives under standard conditions, providing high yields of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::040f9e5da9bc91bc5e9efd24288894d6
http://hdl.handle.net/11588/883943

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3-benzazecine-based cyclic allene derivatives as highly potent P-glycoprotein inhibitors overcoming doxorubicin multidrug resistance

Autor: Maxim S. Kobzev, Alexander A. Titov, Saverio Cellamare, Modesto de Candia, Alexey V. Varlamov, Mauro Niso, Tatiana N. Borisova, Leonid G. Voskressensky, Nicola Antonio Colabufo, Leonardo Pisani, Cosimo Altomare

Publikováno v: Future Medicinal Chemistry. 11:2095-2106

Aim: Enamino 3-benzazecine compounds, incorporating the C6-C8 allene system, were synthesized and evaluated in vitro as inhibitors of P-glycoprotein (P-gp) and/or multidrug resistance-associated protein 1 (MRP1), two efflux pumps mainly connected wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fb6da2de720f4de3840b4d151cc7946
https://doi.org/10.4155/fmc-2019-0037

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Away from Flatness: Unprecedented Nitrogen-Bridged Cyclopenta[

Autor: Alexander A, Titov, Maxim S, Kobzev, Marco, Catto, Modesto de, Candia, Nicola, Gambacorta, Nunzio, Denora, Leonardo, Pisani, Orazio, Nicolotti, Tatiana N, Borisova, Alexey V, Varlamov, Leonid G, Voskressensky, Cosimo D, Altomare

Publikováno v: ACS chemical neuroscience. 12(2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::110d249ba9ed39bf2b625e50514f78ad
https://pubmed.ncbi.nlm.nih.gov/33395258

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Synthesis of 8-phenyl substituted 3-benzazecines with allene moiety, their thermal rearrangement and evaluation as acetylcholinesterase inhibitors

Autor: Maxim S, Kobzev, Alexander A, Titov, Elena V, Alexandrova, Rosa, Purgatorio, Marco, Catto, Elena A, Sorokina, Tatiana N, Borisova, Alexey V, Varlamov, Cosimo D, Altomare, Leonid G, Voskressensky

Publikováno v: Molecular diversity. 26(2)

Various 4'-R-substituted phenyl azacyclic allenes were synthesized in good yields, and their thermal transformations were studied. For the first time, the obtained rearrangement products-new N-bridged cyclopenta[a]indenes, and the corresponding paren

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0d2d1e4dc7edc0a388148f3bfdde6e9b
https://pubmed.ncbi.nlm.nih.gov/33538985

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