Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Maxim N. Shokhirev"'
Autor:
Maxim N. Shokhirev, Daniel J. Kramer, Janie Corley, Simon R. Cox, Trinna L. Cuellar, Adiv A. Johnson
Publikováno v:
Frontiers in Aging, Vol 5 (2024)
While earlier first-generation epigenetic aging clocks were trained to estimate chronological age as accurately as possible, more recent next-generation clocks incorporate DNA methylation information more pertinent to health, lifestyle, and/or outcom
Externí odkaz:
https://doaj.org/article/f4b4f1b4321c421aa2658ccd019d25a7
Autor:
Shani Stern, Shong Lau, Andreea Manole, Idan Rosh, Menachem Mendel Percia, Ran Ben Ezer, Maxim N. Shokhirev, Fan Qiu, Simon Schafer, Abed AlFatah Mansour, Kile P. Mangan, Tchelet Stern, Polina Ofer, Yam Stern, Ana Paula Diniz Mendes, Jose Djamus, Lynne Randolph Moore, Ritu Nayak, Sapir Havusha Laufer, Aidan Aicher, Amanda Rhee, Thomas L. Wong, Thao Nguyen, Sara B. Linker, Beate Winner, Beatriz C. Freitas, Eugenia Jones, Irit Sagi, Cedric Bardy, Alexis Brice, Juergen Winkler, Maria C. Marchetto, Fred H. Gage
Publikováno v:
npj Parkinson's Disease, Vol 8, Iss 1, Pp 1-16 (2022)
Abstract Several mutations that cause Parkinson’s disease (PD) have been identified over the past decade. These account for 15–25% of PD cases; the rest of the cases are considered sporadic. Currently, it is accepted that PD is not a single monol
Externí odkaz:
https://doaj.org/article/2fa050a5687248eaa0da9d23e96a5eb4
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/704e97e1fe394dbbaa6a0638ca33fd51
Autor:
Kelly J. Heard, Maxim N. Shokhirev, Caroline Becronis, Callie Fredlender, Nadia Zahid, Amy T. Le, Yuan Ji, Michelle Skime, Timothy Nelson, Daniel Hall-Flavin, Richard Weinshilboum, Fred H. Gage, Krishna C. Vadodaria
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Major depressive disorder (MDD) is a prevalent psychiatric disorder, and exposure to stress is a robust risk factor for MDD. Clinical data and rodent models have indicated the negative impact of chronic exposure to stress-induced hormones li
Externí odkaz:
https://doaj.org/article/753b9b999f8c450c8e0472172f86f547
A set of common buccal CpGs that predict epigenetic age and associate with lifespan-regulating genes
Publikováno v:
iScience, Vol 25, Iss 11, Pp 105304- (2022)
Summary: Epigenetic aging clocks are computational models that use DNA methylation sites to predict age. Since cheek swabs are non-invasive and painless, collecting DNA from buccal tissue is highly desirable. Here, we review 11 existing clocks that h
Externí odkaz:
https://doaj.org/article/07aa71e761ed4c6d861a3ed97068d85e
The TAM receptor tyrosine kinases Axl and Mer drive the maintenance of highly phagocytic macrophages
Autor:
Lidia Jiménez-García, Christopher Mayer, Patrick G. Burrola, Youtong Huang, Maxim N. Shokhirev, Greg Lemke
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Many apoptotic thymocytes are generated during the course of T cell selection in the thymus, yet the machinery through which these dead cells are recognized and phagocytically cleared is incompletely understood. We found that the TAM receptor tyrosin
Externí odkaz:
https://doaj.org/article/8260602afa754d16a92b4621e051de6a
Autor:
Devin Kepchia, Ling Huang, Richard Dargusch, Robert A. Rissman, Maxim N. Shokhirev, Wolfgang Fischer, David Schubert
Publikováno v:
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-20 (2020)
Abstract Background All cells accumulate insoluble protein aggregates throughout their lifespan. While many studies have characterized the canonical disease-associated protein aggregates, such as those associated with amyloid plaques, additional, und
Externí odkaz:
https://doaj.org/article/2d2aa71f62ab406e8c0f10373ce85c5c
Autor:
Debha N. Amatya, Sara B. Linker, Ana P.D. Mendes, Renata Santos, Galina Erikson, Maxim N. Shokhirev, Yuansheng Zhou, Tatyana Sharpee, Fred H. Gage, Maria C. Marchetto, Yeni Kim
Publikováno v:
Stem Cell Reports, Vol 13, Iss 3, Pp 474-484 (2019)
Summary: Neuronal activity can be modeled as a nonlinear dynamical system to yield measures of neuronal state and dysfunction. The electrical recordings of stem cell-derived neurons from individuals with autism spectrum disorder (ASD) and controls we
Externí odkaz:
https://doaj.org/article/2412d90c6fa84086966d567bd6dc98e6
Autor:
Jovylyn Gatchalian, Shivani Malik, Josephine Ho, Dong-Sung Lee, Timothy W. R. Kelso, Maxim N. Shokhirev, Jesse R. Dixon, Diana C. Hargreaves
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
The BAF complex is a multi-subunit chromatin remodeling complex that plays important roles in transcription regulation. Here the authors provide evidence that BRD9 and GLTSCR1/BICRA or its paralog GLTSCR1-like/BICRAL define a non-canonical BAF comple
Externí odkaz:
https://doaj.org/article/68252e2a987241adafd12cb3fa6d9025
Autor:
Jason G. Fleischer, Roberta Schulte, Hsiao H. Tsai, Swati Tyagi, Arkaitz Ibarra, Maxim N. Shokhirev, Ling Huang, Martin W. Hetzer, Saket Navlakha
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-8 (2018)
Abstract Biomarkers of aging can be used to assess the health of individuals and to study aging and age-related diseases. We generate a large dataset of genome-wide RNA-seq profiles of human dermal fibroblasts from 133 people aged 1 to 94 years old t
Externí odkaz:
https://doaj.org/article/12dd11bf4565406cae4c9853a19596fb