Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Maxim N Shokhirev"'
Autor:
Isabella Farhy-Tselnicker, Matthew M Boisvert, Hanqing Liu, Cari Dowling, Galina A Erikson, Elena Blanco-Suarez, Chen Farhy, Maxim N Shokhirev, Joseph R Ecker, Nicola J Allen
Publikováno v:
eLife, Vol 10 (2021)
Astrocytes regulate the formation and function of neuronal synapses via multiple signals; however, what controls regional and temporal expression of these signals during development is unknown. We determined the expression profile of astrocyte synaps
Externí odkaz:
https://doaj.org/article/9cd09bb480914decb017a9521b470863
Autor:
Bettina J Lehman, Fernando J Lopez-Diaz, Thom P Santisakultarm, Linjing Fang, Maxim N Shokhirev, Kenneth E Diffenderfer, Uri Manor, Beverly M Emerson
Publikováno v:
PLoS Genetics, Vol 17, Iss 1, p e1009277 (2021)
The nuclear protein CCCTC-binding factor (CTCF) has diverse roles in chromatin architecture and gene regulation. Functionally, CTCF associates with thousands of genomic sites and interacts with proteins, such as cohesin, or non-coding RNAs to facilit
Externí odkaz:
https://doaj.org/article/885202f5c4b9446984f6463da2b4e510
Autor:
Antonio Currais, Ling Huang, Joshua Goldberg, Michael Petrascheck, Gamze Ates, António Pinto-Duarte, Maxim N Shokhirev, David Schubert, Pamela Maher
Publikováno v:
eLife, Vol 8 (2019)
Because old age is the greatest risk factor for dementia, a successful therapy will require an understanding of the physiological changes that occur in the brain with aging. Here, two structurally distinct Alzheimer's disease (AD) drug candidates, CM
Externí odkaz:
https://doaj.org/article/762cb486b87d4e0ca58ae16661257ea1
Autor:
Maxim N Shokhirev, Jonathan Almaden, Jeremy Davis‐Turak, Harry A Birnbaum, Theresa M Russell, Jesse A D Vargas, Alexander Hoffmann
Publikováno v:
Molecular Systems Biology, Vol 11, Iss 2, Pp 1-16 (2015)
Abstract Understanding the functions of multi‐cellular organs in terms of the molecular networks within each cell is an important step in the quest to predict phenotype from genotype. B‐lymphocyte population dynamics, which are predictive of immu
Externí odkaz:
https://doaj.org/article/cec928a1a4fe4d4abbe89e013f33ebc9
Autor:
Timothy W R Kelso, Devin K Porter, Maria Luisa Amaral, Maxim N Shokhirev, Christopher Benner, Diana C Hargreaves
Publikováno v:
eLife, Vol 6 (2017)
ARID1A, a subunit of the SWI/SNF chromatin remodeling complex, is frequently mutated in cancer. Deficiency in its homolog ARID1B is synthetically lethal with ARID1A mutation. However, the functional relationship between these homologs has not been ex
Externí odkaz:
https://doaj.org/article/a449aac1fa7744e5be6b531a3542b1b7
Autor:
Maya Saison-Ridinger, Kathleen E DelGiorno, Tejia Zhang, Annabelle Kraus, Randall French, Dawn Jaquish, Crystal Tsui, Galina Erikson, Benjamin T Spike, Maxim N Shokhirev, Christopher Liddle, Ruth T Yu, Michael Downes, Ronald M Evans, Alan Saghatelian, Andrew M Lowy, Geoffrey M Wahl
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0189051 (2017)
Pancreatic ductal adenocarcinoma (PDAC) is characterized by an extremely dense fibrotic stroma, which contributes to tumor growth, metastasis, and drug resistance. During tumorigenesis, quiescent pancreatic stellate cells (PSCs) are activated and bec
Externí odkaz:
https://doaj.org/article/23aab20296124703a94f74164e9e8040
Autor:
Joe Nassour, Lucia Gutierrez Aguiar, Adriana Correia, Tobias T. Schmidt, Laura Mainz, Sara Przetocka, Candy Haggblom, Nimesha Tadepalle, April Williams, Maxim N. Shokhirev, Semih C. Akincilar, Vinay Tergaonkar, Gerald S. Shadel, Jan Karlseder
Publikováno v:
Nature. 614:767-773
Cancers arise through the accumulation of genetic and epigenetic alterations that enable cells to evade telomere-based proliferative barriers and achieve immortality. One such barrier is replicative crisis—an autophagy-dependent program that elimin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53d9ac87333d86767633e8a5901f1b7d
https://doi.org/10.1038/s41586-023-05710-8
https://doi.org/10.1038/s41586-023-05710-8
Autor:
Alison L. M. Caldwell, Laura Sancho, James Deng, Alexandra Bosworth, Audrey Miglietta, Jolene K. Diedrich, Maxim N. Shokhirev, Nicola J. Allen
Publikováno v:
Nature Neuroscience. 25:1163-1178
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b548649228b1e9107512e378a0130b78
https://doi.org/10.1038/s41593-022-01150-1
https://doi.org/10.1038/s41593-022-01150-1
Autor:
Reuben J. Shaw, Rebecca Berdeaux, Robert A. Screaton, Maxim N. Shokhirev, April E. Williams, Hector M. Galvez, Amanda Hutchins, T.J. Rymoff, Debbie S. Ross, Liliana I. Vera, Robert U. Svensson, Anwesh Kamireddy, Sonja N. Brun, Lillian J. Eichner, Pablo E. Hollstein
Supplemental Data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::004e8302e03d44f61ec3ba546c257239
https://doi.org/10.1158/2159-8290.22532756
https://doi.org/10.1158/2159-8290.22532756
Autor:
Reuben J. Shaw, Rebecca Berdeaux, Robert A. Screaton, Maxim N. Shokhirev, April E. Williams, Hector M. Galvez, Amanda Hutchins, T.J. Rymoff, Debbie S. Ross, Liliana I. Vera, Robert U. Svensson, Anwesh Kamireddy, Sonja N. Brun, Lillian J. Eichner, Pablo E. Hollstein
Mutations in the LKB1 (also known as STK11) tumor suppressor are the third most frequent genetic alteration in non–small cell lung cancer (NSCLC). LKB1 encodes a serine/threonine kinase that directly phosphorylates and activates 14 AMPK family kina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a88f344e09faf5fe67fa60dbf2d0358c
https://doi.org/10.1158/2159-8290.c.6546818
https://doi.org/10.1158/2159-8290.c.6546818