Zobrazeno 1 - 10
of 205
pro vyhledávání: '"Maxim N Artyomov"'
Autor:
Rahul Tyagi, Bruce A Rosa, Amanda Swain, Maxim N Artyomov, Douglas P Jasmer, Makedonka Mitreva
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-21 (2024)
Abstract Background Parasitic nematodes, significant pathogens for humans, animals, and plants, depend on diverse organ systems for intra-host survival. Understanding the cellular diversity and molecular variations underlying these functions holds pr
Externí odkaz:
https://doaj.org/article/8cb3356f6aa64b94a6f48ba20a3e9835
Autor:
Maksim Kleverov, Daria Zenkova, Vladislav Kamenev, Margarita Sablina, Maxim N Artyomov, Alexey A Sergushichev
Publikováno v:
eLife, Vol 13 (2024)
Transcriptomic profiling became a standard approach to quantify a cell state, which led to the accumulation of huge amount of public gene expression datasets. However, both reuse of these datasets or analysis of newly generated ones requires signific
Externí odkaz:
https://doaj.org/article/404f53119a7f4c628614a6757ed3f5cd
Autor:
Jacob A Van Winkle, Stefan T Peterson, Elizabeth A Kennedy, Michael J Wheadon, Harshad Ingle, Chandni Desai, Rachel Rodgers, David A Constant, Austin P Wright, Lena Li, Maxim N Artyomov, Sanghyun Lee, Megan T Baldridge, Timothy J Nice
Publikováno v:
eLife, Vol 11 (2022)
Interferon-lambda (IFN-λ) protects intestinal epithelial cells (IECs) from enteric viruses by inducing expression of antiviral IFN-stimulated genes (ISGs). Here, we find that bacterial microbiota stimulate a homeostatic ISG signature in the intestin
Externí odkaz:
https://doaj.org/article/49f905267f26475caccf534d5cf8c0dd
Autor:
Andrea Santeford, Aaron Y Lee, Abdoulaye Sene, Lynn M Hassman, Alexey A Sergushichev, Ekaterina Loginicheva, Maxim N Artyomov, Philip A Ruzycki, Rajendra S Apte
Publikováno v:
eLife, Vol 10 (2021)
Macrophages undergo programmatic changes with age, leading to altered cytokine polarization and immune dysfunction, shifting these critical immune cells from protective sentinels to disease promoters. The molecular mechanisms underlying macrophage in
Externí odkaz:
https://doaj.org/article/6fb8d853a91b4d1da48547761a3b3cc2
Autor:
Dorothy K Sojka, Beatrice Plougastel-Douglas, Liping Yang, Melissa A Pak-Wittel, Maxim N Artyomov, Yulia Ivanova, Chao Zhong, Julie M Chase, Paul B Rothman, Jenny Yu, Joan K Riley, Jinfang Zhu, Zhigang Tian, Wayne M Yokoyama
Publikováno v:
eLife, Vol 3 (2014)
Natural killer (NK) cells belong to the innate immune system; they can control virus infections and developing tumors by cytotoxicity and producing inflammatory cytokines. Most studies of mouse NK cells, however, have focused on conventional NK (cNK)
Externí odkaz:
https://doaj.org/article/37db9d0ecffd4e0495ccda2885594afa
Autor:
Fadi Towfic, Jason M Funt, Kevin D Fowler, Shlomo Bakshi, Eran Blaugrund, Maxim N Artyomov, Michael R Hayden, David Ladkani, Rivka Schwartz, Benjamin Zeskind
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e83757 (2014)
For decades, policies regarding generic medicines have sought to provide patients with economical access to safe and effective drugs, while encouraging the development of new therapies. This balance is becoming more challenging for physicians and reg
Externí odkaz:
https://doaj.org/article/d9ac4720e37d456aa3e0668f876f8ecc
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e59701 (2013)
Our ability to successfully intervene in disease processes is dependent on definitive diagnosis. In the case of autoimmune disease, this is particularly challenging because progression of disease is lengthy and multifactorial. Here we show the first
Externí odkaz:
https://doaj.org/article/58be6590cb4549daadc8d19eb1753cb6
Publikováno v:
PLoS Computational Biology, Vol 6, Iss 5, p e1000785 (2010)
With relatively low efficiency, differentiated cells can be reprogrammed to a pluripotent state by ectopic expression of a few transcription factors. An understanding of the mechanisms that underlie data emerging from such experiments can help design
Externí odkaz:
https://doaj.org/article/1684f565167e4f849973b93c4f588465
Publikováno v:
Naučno-tehničeskij Vestnik Informacionnyh Tehnologij, Mehaniki i Optiki, Vol 23, Iss 5, Pp 989-1000 (2023)
Solving the problem of predicting the immune response against foreign protein sequence fragments processed by cells is one of the major milestones on the road to the personalized cancer vaccine development. The selection of peptides participating i
Externí odkaz:
https://doaj.org/article/d7f4674fa6e541f6807ff0e82ac8a0bc
Autor:
Mandy M. Chan, Sabine Daemen, Joseph W. Beals, Marina Terekhova, Bin Q. Yang, Christina F. Fu, Li He, Arick C. Park, Gordon I. Smith, Babak Razani, Kathleen Byrnes, Wandy L. Beatty, Shaina R. Eckhouse, J. Christopher Eagon, Daniel Ferguson, Brian N. Finck, Samuel Klein, Maxim N. Artyomov, Joel D. Schilling
Publikováno v:
JHEP Reports, Vol 5, Iss 11, Pp 100877- (2023)
Background & Aims: Metabolic dysfunction-associated fatty liver disease (MAFLD) is a common complication of obesity with a hallmark feature of hepatic steatosis. Recent data from animal models of MAFLD have demonstrated substantial changes in macroph
Externí odkaz:
https://doaj.org/article/899e9858356b4c83b39c77d67e35c9a8