Acetylcholinesterase of the sand fly, Phlebotomus papatasi (Scopoli): construction, expression and biochemical properties of the G119S orthologous mutant

Autor: Kevin B Temeyer, Fan Tong, Maxim M Totrov, Alexander P Tuckow, Qiao-hong Chen, Paul R Carlier, Adalberto A Pérez de León, Jeffrey R Bloomquist

Publikováno v: Parasites & Vectors, Vol 7, Iss 1, Pp 1-10 (2014)

Abstract Background Phlebotomus papatasi vectors zoonotic cutaneous leishmaniasis. Previous expression of recombinant P. papatasi acetylcholinesterase (PpAChE1) revealed 85% amino acid sequence identity to mosquito AChE and identified synthetic carba

Externí odkaz: https://doaj.org/article/ac75ae070070468a9f50a55885c01f9b

Voltage-Sensitive Potassium Kv2 Channels as New Targets for Insecticides

Autor: Ming Ma, Jeffrey R. Bloomquist, Astha Verma, Maxim M. Totrov, James M. Mutunga, Paul R. Carlier, Rafique Islam

Publikováno v: Biopesticides: State of the Art and Future Opportunities ISBN: 9780841229990
Biopesticides: State of the Art and Future Opportunities

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::05bcff03cc9e75ff4767cad734055852
https://doi.org/10.1021/bk-2014-1172.ch006

The use of the magnetic field effect for studying a chemiluminescent chemical reaction in aqueous solution. Reaction rate constants and lifetimes of intermediate molecules

Autor: Maxim M. Totrov, Eugene Frankevich, M. M. Triebel, George E. Zorinyants

Publikováno v: Chemical Physics Letters. 214:315-320

The phase shift magnetic field effect technique is applied for investigation of the chemiluminescent (ChL) reaction of luminol oxidation by potassium ferricyanide in aqueous alkali solution. The external modulated magnetic field changed the rate cons

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3fc6722ea528f738707fafc25d39fa61
https://doi.org/10.1016/0009-2614(93)85642-2

β-Carboline-3-carboxamide Antimalarials: Structure-Activity Relationship, ADME-Tox Studies, and Resistance Profiling.

Autor: Mathew J; Department of Chemistry and Virginia Tech Center for Drug Discovery, Virginia Tech, 1040 Drillfield Drive, Blacksburg, Virginia 24061, United States., Zhou B; Department of Chemistry and Virginia Tech Center for Drug Discovery, Virginia Tech, 1040 Drillfield Drive, Blacksburg, Virginia 24061, United States.; Department of Pharmaceutical Sciences, University of Illinois Chicago, 833 S Wood Street, Chicago, Illinois 60612, United States., Haney RS; Department of Biochemistry and Molecular Biology and Center for Tropical and Emerging Global Diseases, University of Georgia, 120 E. Green Street, Athens, Georgia 30602, United States., Kunz KA; Department of Pharmaceutical Sciences, University of Illinois Chicago, 833 S Wood Street, Chicago, Illinois 60612, United States., Do Amaral LS; Department of Biochemistry and Molecular Biology and Center for Tropical and Emerging Global Diseases, University of Georgia, 120 E. Green Street, Athens, Georgia 30602, United States., Roy Chowdhury R; Department of Chemistry and Virginia Tech Center for Drug Discovery, Virginia Tech, 1040 Drillfield Drive, Blacksburg, Virginia 24061, United States.; Department of Pharmaceutical Sciences, University of Illinois Chicago, 833 S Wood Street, Chicago, Illinois 60612, United States., Butler JH; Department of Biochemistry and Molecular Biology and Center for Tropical and Emerging Global Diseases, University of Georgia, 120 E. Green Street, Athens, Georgia 30602, United States., Li H; Department of Chemistry and Virginia Tech Center for Drug Discovery, Virginia Tech, 1040 Drillfield Drive, Blacksburg, Virginia 24061, United States., Chakraborty AJ; Department of Chemistry and Virginia Tech Center for Drug Discovery, Virginia Tech, 1040 Drillfield Drive, Blacksburg, Virginia 24061, United States., Tabassum A; Department of Chemistry and Virginia Tech Center for Drug Discovery, Virginia Tech, 1040 Drillfield Drive, Blacksburg, Virginia 24061, United States., Bremers EK; Department of Biochemistry and Molecular Biology and Center for Tropical and Emerging Global Diseases, University of Georgia, 120 E. Green Street, Athens, Georgia 30602, United States., Merino EF; Department of Biochemistry and Molecular Biology and Center for Tropical and Emerging Global Diseases, University of Georgia, 120 E. Green Street, Athens, Georgia 30602, United States., Coyle R; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, U.K.; Biological Chemistry and Drug Discovery, Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee DD1 4HN, U.K., Lee MCS; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, U.K.; Biological Chemistry and Drug Discovery, Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee DD1 4HN, U.K., Baud D; Medicines for Malaria Venture, Geneva 1215, Switzerland., Brand S; Medicines for Malaria Venture, Geneva 1215, Switzerland., Totrov M; Molsoft LLC, 11999 Sorrento Valley Road, San Diego, California 92121, United States., Cassera MB; Department of Biochemistry and Molecular Biology and Center for Tropical and Emerging Global Diseases, University of Georgia, 120 E. Green Street, Athens, Georgia 30602, United States., Carlier PR; Department of Chemistry and Virginia Tech Center for Drug Discovery, Virginia Tech, 1040 Drillfield Drive, Blacksburg, Virginia 24061, United States.; Department of Pharmaceutical Sciences, University of Illinois Chicago, 833 S Wood Street, Chicago, Illinois 60612, United States.; Department of Chemistry, University of Illinois Chicago, 845 W Taylor Street, Chicago, Illinois 60607, United States.

Publikováno v: ACS infectious diseases [ACS Infect Dis] 2024 Nov 08; Vol. 10 (11), pp. 3951-3962. Date of Electronic Publication: 2024 Oct 28.

Software and Databases for Protein-Protein Docking.

Autor: Jarończyk M; National Medicines Institute, Warsaw, Poland., Abagyan R; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA., Totrov M; Molsoft, LLC, La Jolla, CA, USA.

Publikováno v: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2024; Vol. 2780, pp. 129-138.