S-Nitrosylation of Divalent Metal Transporter 1 Enhances Iron Uptake to Mediate Loss of Dopaminergic Neurons and Motoric Deficit

Autor: Katherine C. M. Chew, Seok Ting Ang, Sanjay Khanna, Bryce W.Q. Tan, Fai Tsang, Chao Liu, Chengwu Zhang, Bobby Tan, Mui Cheng Liang, Dejie Yu, Hwee Tong Tan, Tuck Wah Soong, John Jia En Chua, Yee Kit Tai, Bing Han Chai, Shun Qiang Lo, Jia Ying Tang, Kah-Leong Lim, Mitchell K.P. Lai, Maxey C. M. Chung

Publikováno v: J Neurosci

Elevated iron deposition has been reported in Parkinson's disease (PD). However, the route of iron uptake leading to high deposition in the substantia nigra is unresolved. Here, we show a mechanism in enhanced Fe2+uptake via S-nitrosylation of divale

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d0194f86804c726c92d036a95f3017b
https://doi.org/10.1523/jneurosci.3262-17.2018

Next Generation Proteomics for Clinical Biomarker Detection Using SWATH-MS

Autor: Hwee Tong Tan, Maxey C. M. Chung, Qifeng Lin

Publikováno v: Methods in Molecular Biology ISBN: 9781493992317

The technology of "sequential windowed acquisition of all theoretical fragment ion spectra," known as SWATH-MS, is rapidly gaining popularity as a next generation proteomics technology for comprehensive proteome quantitation. In this chapter, we desc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::672d20b16c44dc77ea55ebf8b0bb445b
https://doi.org/10.1007/978-1-4939-9232-4_1

Subcellular Proteome Landscape of Human Embryonic Stem Cells Revealed Missing Membrane Proteins

Autor: Chia-Li Han, Ching-Yu Chuang, Mehari Muuz Weldemariam, Hung-Chih Kuo, Ghasem Hosseini Salekdeh, Faezeh Shekari, Yu-Ju Chen, Wai-Kok Choong, Reta Birhanu Kitata, Maxey C. M. Chung, Ting-Yi Sung, Wei-Ting Hsu, Fuchu He

Publikováno v: Journal of proteome research. 17(12)

Human embryonic stem cells (hESCs) have the capacity for self-renewal and multilineage differentiation, which are of clinical importance for regeneration medicine. Despite the significant progress of hESC study, the complete hESC proteome atlas, espe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::343e114f614db14371c8c288a3b65231
https://pubmed.ncbi.nlm.nih.gov/30203655

Biomarkers for Recurrence of Hepatocellular Carcinoma

Autor: Seow Chong Lee, Hwee Tong Tan, Maxey C. M. Chung

Publikováno v: Biomarkers in Disease: Methods, Discoveries and Applications ISBN: 9789400776746
Biomarkers in Disease: Methods, Discoveries and Applications
Biomarkers in Disease: Methods, Discoveries and Applications ISBN: 9789400777422

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7cf4c0d0601089bf6777ccda60216ba
https://doi.org/10.1007/978-94-007-7675-3_9

Sieving through the cancer secretome

Autor: Hwee Tong Tan, Qifeng Lin, Hannah Soo Rei Lim, Maxey C. M. Chung

Publikováno v: Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1834:2360-2371

Cancer is among the most prevalent and serious health problems worldwide. Therefore, there is an urgent need for novel cancer biomarkers with high sensitivity and specificity for early detection and management of the disease. The cancer secretome, en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5640fb52fdb290b558e2507391ee2650
https://doi.org/10.1016/j.bbapap.2013.01.030