Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Max-Hinderk Schuler"'
Autor:
Max-Hinderk Schuler, Adam L. Hughes
Publikováno v:
Molecular cell. 82(6)
Li et al. (2022) discover that Toxoplasma infection triggers remodeling of the mitochondrial outer membrane through generation of a mitochondrial subdomain termed "structure positive for outer mitochondrial membrane" (SPOT).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b8978191539ffb3c4682c20c39d508e
https://pubmed.ncbi.nlm.nih.gov/35025629
https://pubmed.ncbi.nlm.nih.gov/35025629
SUMMARYWe recently identified a new cellular structure in yeast, called the Mitochondrial-Derived Compartment (MDC), that forms on mitochondria in response to amino acid excess. While emerging evidence supports an important function for MDCs in prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1fdfd131b08118ea02ff292f5545ac03
https://doi.org/10.1101/2020.12.23.424218
https://doi.org/10.1101/2020.12.23.424218
Autor:
Tianyao Xiao, Benoît Kornmann, Adam Hughes, Janet M. Shaw, Max-Hinderk Schuler, Alyssa M. English
Publikováno v:
The Journal of Cell Biology
Mitochondrial-derived compartments (MDCs) regulate the mitochondrial proteome in response to nutrient stress. English et al. now show that the ERMES complex and the conserved GTPase Gem1 promote MDC biogenesis at sites of contact between the endoplas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d7b4bcafa0f28f7760bf0a50053bfda
http://europepmc.org/articles/PMC7588143
http://europepmc.org/articles/PMC7588143
SUMMARYAmino acids are essential building blocks of life. However, increasing evidence suggests that elevated amino acids cause cellular toxicity associated with numerous metabolic disorders. How cells cope with elevated amino acids remains poorly un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acb9c096875b40c07d8805dca5e36adf
https://doi.org/10.1101/2020.03.13.991091
https://doi.org/10.1101/2020.03.13.991091
Autor:
Alyssa M. English, Janet M. Shaw, Thane J. Campbell, Max-Hinderk Schuler, Adam Hughes, Tianyao Xiao
Publikováno v:
Mol Cell
Amino acids are essential building blocks of life. However, increasing evidence suggests that elevated amino acids cause cellular toxicity associated with numerous metabolic disorders. How cells cope with elevated amino acids remains poorly understoo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb8856e6a69339fa5756727fe304b448
https://doi.org/10.1016/j.molcel.2021.08.021
https://doi.org/10.1016/j.molcel.2021.08.021
Autor:
Max-Hinderk Schuler, Wesley Skillern, Srigokul Upadhyayula, Tom Kirchhausen, Brian Cunniff, Agnieszka Lewandowska, Janet M. Shaw, Giuseppe Di Caprio
Publikováno v:
Molecular Biology of the Cell
The ratio of ATP:ADP is highest at perinuclear sites, where mitochondria are dense, and dissipates toward the periphery. Miro1 positions mitochondria toward the cortical cytoskeleton. Deletion of Miro1 results in perinuclear clustering of mitochondri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adb3626d41af50294f05870c0f409264
https://doi.org/10.1091/mbc.e16-10-0741
https://doi.org/10.1091/mbc.e16-10-0741
Autor:
Max-Hinderk Schuler, Adam Hughes
Publikováno v:
Cell Metabolism. 31:886-887
In this issue of Cell Metabolism, Herkenne et al. (2020) show that the mitochondrial fusion protein OPA1 promotes angiogenesis independent of its function in mitochondrial dynamics, identifying a key new therapeutic target to prevent vascular growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b27f6738f5d3116e4447eeb8b2c18a9
https://doi.org/10.1016/j.cmet.2020.04.014
https://doi.org/10.1016/j.cmet.2020.04.014
Autor:
Max-Hinderk Schuler, Francesca Di Bartolomeo, Guenther Daum, Christoph U. Mårtensson, Thomas Becker
Publikováno v:
Journal of Biological Chemistry. 291:18718-18729
Two protein translocases transport precursor proteins into or across the inner mitochondrial membrane. The presequence translocase (TIM23 complex) sorts precursor proteins with a cleavable presequence either into the matrix or into the inner membrane
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22dcd98a2ad8f90dfafc45657de0e8aa
https://doi.org/10.1074/jbc.m116.722694
https://doi.org/10.1074/jbc.m116.722694
Autor:
Max-Hinderk Schuler, Susanne E. Horvath, Lena Böttinger, Lena-Sophie Wenz, Francesca Di Bartolomeo, Günther Daum, Thomas Becker
Publikováno v:
Journal of Biological Chemistry. 290:26523-26532
Two protein translocases drive the import of β-barrel precursor proteins into the mitochondrial outer membrane: The translocase of the outer membrane (TOM complex) promotes transport of the precursor to the intermembrane space, whereas the sorting a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a759b2b7b865b11972720f496d9b179c
https://doi.org/10.1074/jbc.m115.687921
https://doi.org/10.1074/jbc.m115.687921
Autor:
György Hajnóczky, Eva L. Feldman, David Weaver, Cheryl A. Palmer, Valentina Debattisti, Agnieszka Lewandowska, Takumi Koshiba, Dane Maxfield, Stefan M. Pulst, Janet M. Shaw, Sang S. Oh, Max-Hinderk Schuler, Jane L. Macfarlane, Gerald W. Saunders, Nathan K. Smith, Tammy T. Nguyen
Defective mitochondrial distribution in neurons is proposed to cause ATP depletion and calcium-buffering deficiencies that compromise cell function. However, it is unclear whether aberrant mitochondrial motility and distribution alone are sufficient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bacc475e118a1d00dd78f5d8cdf5879d
https://europepmc.org/articles/PMC4156725/
https://europepmc.org/articles/PMC4156725/