Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Max Warncke"'
Autor:
Ole Kristian Greiner-Tollersrud, Máté Krausz, Vincent Boehler, Aikaterini Polyzou, Maximilian Seidl, Ambra Spahiu, Zeinab Abdullah, Katarzyna Andryka-Cegielski, Felix Immunuel Dominick, Katrin Huebscher, Andreas Goschin, Cristian R. Smulski, Eirini Trompouki, Regina Link, Hilmar Ebersbach, Honnappa Srinivas, Martine Marchant, Georgios Sogkas, Dieter Staab, Cathrine Vågbø, Danilo Guerini, Sebastian Baasch, Eicke Latz, Gunther Hartmann, Philippe Henneke, Roger Geiger, Xiao P. Peng, Bodo Grimbacher, Eva Bartok, Ingrun Alseth, Max Warncke, Michele Proietti
Publikováno v:
Cell Reports, Vol 43, Iss 11, Pp 114899- (2024)
Summary: Although adenosine deaminase 2 (ADA2) is considered an extracellular ADA, evidence questions the physiological relevance of this activity. Our study reveals that ADA2 localizes within the lysosomes, where it is targeted through modifications
Externí odkaz:
https://doaj.org/article/f6e14d70f0b648c3aca83261512b83d8
Autor:
Katrin Hübscher, Eirini Trompouki, Danilo Guerini, Roger Geiger, Ole K. Greiner-Tollersrud, Honnappa Srinivas, Sebastian Baasch, Eva Bartok, Hilmar Ebersbach, Salvatore Raieli, Jan Ole Olsen, Martine Marchant, Bodo Grimbacher, Vincent Boehler, Georg Kochs, Aikaterini Polyzou, Regina Link, Cristian R. Smulski, Gunther Hartmann, Máté Krausz, Michele Proietti, Dieter Staab, Maximilian Seidl, Johanna Schepp, Philipp Henneke, Max Warncke
Deficiency of adenosine deaminase 2 (DADA2) is a severe, congenital syndrome, which manifests with hematologic, immunologic and inflammatory pathologies. DADA2 is caused by biallelic mutations in ADA2, but the function of ADA2, and the mechanistic li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26a38fc6bbd8be9ab969f0fdbf4f90d2
https://doi.org/10.1101/2020.06.21.162990
https://doi.org/10.1101/2020.06.21.162990
Autor:
Kirsten D. Mertz, Fernanda do Valle Duraes, Rachel Cuttat, Katy Darribat, Ulrike Naumann, Guglielmo Roma, Armelle Lafont, Swann Gaulis, Sabina Pfister, Martin Beibel, Jianping Li, Max Warncke, Kea Martin, Grazyna Wieczorek, Annick Waldt
Publikováno v:
JCI Insight. 5
Acute kidney injury (AKI) and chronic kidney diseases are associated with high mortality and morbidity. Although the underlying mechanisms determining the transition from acute to chronic injury are not completely understood, immune-mediated processe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8d0328a29ccc3ffec499ede36579cd5
https://doi.org/10.1172/jci.insight.130651
https://doi.org/10.1172/jci.insight.130651
Autor:
James S. Rush, Christoph Heusser, Dorothee Müller-Ristig, Peter Ulrich, Christian Bruns, Pascal Espie, Gautier Robert, Doris Weider, Patrick Schmutz, Serge Côté, Max Warncke, Jacinda Ristov, Frank Kolbinger, Francisco Cordoba-Castro, Thierry Flandre, Denise Sickert, Barbara Greutmann, Martin A. Schneider, Mirela Dimitrova
Publikováno v:
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 18(12)
The CD40-CD154 costimulatory pathway is essential for T cell-dependent immune responses, development of humoral memory, and antigen presenting cell function. These immune functions have been implicated in the pathology of multiple autoimmune diseases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f1861052e45b102f4cb5f6a1f9fa141
https://pubmed.ncbi.nlm.nih.gov/29665205
https://pubmed.ncbi.nlm.nih.gov/29665205
Autor:
Andrea Kiessling, Frank R. Brennan, Adriana Milicov, Jennifer Krieg, Babette Wolf, Zaahira Gani, Hannah Morgan, Stewart Jones, Jennifer Sims, Max Warncke
Publikováno v:
Cytokine. 60:828-837
The administration of several monoclonal antibodies (mAbs) to humans has been associated with acute adverse events characterized by clinically significant release of cytokines in the blood. The limited predictive value of toxicology species in this f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c920f2a3e8ce6794dc8ce1aa0a00c005
https://doi.org/10.1016/j.cyto.2012.08.018
https://doi.org/10.1016/j.cyto.2012.08.018
Autor:
Christoph Heusser, Thomas Calzascia, Frank Kolbinger, Michele Coulot, Max Warncke, Nicole Balke, Ratiba Touil
Publikováno v:
The Journal of Immunology. 188:4405-4411
Safety of human therapeutic Abs is generally assessed in nonhuman primates. Whereas IgG1 shows identical FcγR interaction and effector function profile in both species, fundamental differences in the IgG2 and IgG4 Ab subclasses were found between th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd0e20eba883d2634e12a3c229044649
https://doi.org/10.4049/jimmunol.1200090
https://doi.org/10.4049/jimmunol.1200090
Autor:
Brent H. Koehn, Tobias Wertheimer, James L.M. Ferrara, Vincent Schwarze, Patricia A. Taylor, Lukas Schwab, Yvonne Beck, Robert Zeiser, Natalie Stickel, Annette Schmitt-Graeff, Max Warncke, Susumu Nakae, Benjamin M. Matta, Dawn K. Reichenbach, Jason Devlin, Victor Tkachev, Marie Follo, Heth R. Turnquist, Bruce R. Blazar, Justus Duyster, Dietmar Pfeifer, Tobias Junt, Elisabeth Lieberknecht, Heide Dierbach, Quan Liu, Gabriele Prinz, Simon C. Watkins
Publikováno v:
Blood. 125(20)
Interleukin (IL)-33 binding to the receptor suppression of tumorigenicity 2 (ST2) produces pro-inflammatory and anti-inflammatory effects. Increased levels of soluble ST2 (sST2) are a biomarker for steroid-refractory graft-versus-host disease (GVHD)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa77173378bbc603fee44e6afa76b403
https://pubmed.ncbi.nlm.nih.gov/31265507
https://pubmed.ncbi.nlm.nih.gov/31265507
Autor:
Benjamin Matta, Dawn Reichenbach, Vincent Schwarze, Victor Tkachev, Lisa Mathews, Quan Liu, Max Warncke, James Ferrara, Robert Zeiser, Bruce Blazar, Heth Turnquist
Publikováno v:
The Journal of Immunology. 194:140.13-140.13
Graft-versus-host disease (GVHD) is a severe and often fatal complication of allogeneic (allo) hematopoietic cell transplantation (HCT). Total body irradiation (TBI) conditioning of the recipient and subsequent GVHD-associated alloimmune responses ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e0597d4c7b8c0cd4d2e3be202a46807
https://doi.org/10.4049/jimmunol.194.supp.140.13
https://doi.org/10.4049/jimmunol.194.supp.140.13
Autor:
Victor Tkachev, Elizabeth Lieberknecht, Jason Devlin, Tobias Junt, Marie Follo, Tobias Wertheimer, Heide Dierbach, Quan Liu, Gabriele Prinz, Annette Schmitt-Graeff, Simon C. Watkins, Brent H. Koehn, Bruce R. Blazar, Heth R. Turnquist, Natalie Stickel, Patricia A. Taylor, Susumu Nakae, Benjamin M. Matta, Dietmar Pfeifer, Max Warncke, Dawn K. Reichenbach, Justus Duyster, Vincent Schwarze, Robert Zeiser, James L.M. Ferrara, Lukas Schwab, Yvonne Beck
Publikováno v:
Blood. 124:844-844
The IL-1 superfamily member IL-33 is produced in barrier tissues. IL-33 binds to the receptor suppression of tumorigenicity 2 (ST2), expressed on stromal cells, regulatory T cells (Tregs), myeloid derived suppressor cells (MDSCs), and macrophages. IL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53609362cead0e7ee3ee90bfb4aa387f
https://doi.org/10.1182/blood.v124.21.844.844
https://doi.org/10.1182/blood.v124.21.844.844
Publikováno v:
Journal of immunological methods. 310(1-2)
Vaccination with in vitro-generated dendritic cells (DC) that present tumor-associated antigens is a promising approach for immunotherapy of malignant tumors. For optimization of DC-based vaccination protocols, preclinical tumor models that mimic the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43c5ae12ac787e4a4713c3c8817070cf
https://pubmed.ncbi.nlm.nih.gov/16337648
https://pubmed.ncbi.nlm.nih.gov/16337648