Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Max W Richardson"'
Autor:
Rachel S Leibman, Max W Richardson, Christoph T Ellebrecht, Colby R Maldini, Joshua A Glover, Anthony J Secreto, Irina Kulikovskaya, Simon F Lacey, Sarah R Akkina, Yanjie Yi, Farida Shaheen, Jianbin Wang, Keith A Dufendach, Michael C Holmes, Ronald G Collman, Aimee S Payne, James L Riley
Publikováno v:
PLoS Pathogens, Vol 13, Iss 10, p e1006613 (2017)
HIV is adept at avoiding naturally generated T cell responses; therefore, there is a need to develop HIV-specific T cells with greater potency for use in HIV cure strategies. Starting with a CD4-based chimeric antigen receptor (CAR) that was previous
Externí odkaz:
https://doaj.org/article/942f579e40144a97893d9fb154526278
Autor:
M. Angela Aznar, Charly R. Good, Shunichiro Kuramitsu, Parisa Samareh, Sangya Agarwal, Greg Donahue, Kenichi Ishiyama, Nils Wellhausen, Austin K. Rennels, Yujie Ma, Lifeng Tian, Sonia Guedan, Katherine A. Alexander, Zhen Zhang, Philipp C. Rommel, Nathan Singh, Karl M. Glastad, Max W. Richardson, Keisuke Watanabe, Janos L. Tanyi, Mark H. O’Hara, Marco Ruella, Simon F. Lacey, Edmund K. Moon, Stephen J. Schuster, Steven M. Albelda, Lewis L. Lanier, Regina M. Young, Shelley L. Berger, Carl H. June
Publikováno v:
Cancer Research. 82:3602-3602
Chimeric antigen receptor (CAR) T cell immunotherapy is FDA approved for the treatment of a subset of B cell malignancies but has shown limited clinical success in solid tumor therapy. T cell exhaustion is an important factor involved in treatment fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1139f5b8839d87d9d1b304b86a68bc2c
https://doi.org/10.1158/1538-7445.am2022-3602
https://doi.org/10.1158/1538-7445.am2022-3602
Autor:
George J Leslie, Jianbin Wang, Max W Richardson, Beth S Haggarty, Kevin L Hua, Jennifer Duong, Anthony J Secreto, Andrea P O Jordon, Josephine Romano, Kritika E Kumar, Joshua J DeClercq, Philip D Gregory, Carl H June, Michael J Root, James L Riley, Michael C Holmes, James A Hoxie
Publikováno v:
PLoS Pathogens, Vol 12, Iss 11, p e1005983 (2016)
HIV-1 entry can be inhibited by soluble peptides from the gp41 heptad repeat-2 (HR2) domain that interfere with formation of the 6-helix bundle during fusion. Inhibition has also been seen when these peptides are conjugated to anchoring molecules and
Externí odkaz:
https://doaj.org/article/b2848b8f422e4d1cb691aa0474392450
Autor:
Yujie Ma, Charly R. Good, Janos L. Tanyi, Carl H. June, Nathan Singh, Keisuke Watanabe, Lifeng Tian, Mark H. O'Hara, Shelley L. Berger, Shunichiro Kuramitsu, Lewis L. Lanier, Greg Donahue, Sangya Agarwal, Edmund K. Moon, Kenichi Ishiyama, M. Angela Aznar, Nils Wellhausen, Sonia Guedan, Marco Ruella, Stephen J. Schuster, Max W. Richardson, Steven M. Albelda, Parisa Samareh, Zhen Zhang, Regina M. Young, Katherine A. Alexander, Simon F. Lacey
Publikováno v:
Cancer Research. 81:60-60
Chimeric antigen receptor (CAR) T cell therapy has achieved remarkable success in hematological malignancies but remains largely ineffective in solid tumors. A major factor leading to the reduced efficacy of CAR T cell therapy is T cell dysfunction,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85b92a6cdc059a21e2a88a9c099a2b78
https://doi.org/10.1158/1538-7445.am2021-60
https://doi.org/10.1158/1538-7445.am2021-60
Autor:
Keisuke Watanabe, Charly R. Good, Kenichi Ishiyama, Greg Donahue, Marco Ruella, Lewis L. Lanier, Simon F. Lacey, Nathan Singh, Janos L. Tanyi, Austin K. Rennels, Shunichiro Kuramitsu, Yujie Ma, Lifeng Tian, Shelley L. Berger, Karl M. Glastad, Mark H. O'Hara, Regina M. Young, Parisa Samareh, Zhen Zhang, Edmund K. Moon, Carl H. June, M. Angela Aznar, Philipp C. Rommel, Steven M. Albelda, Katherine A. Alexander, Sangya Agarwal, Stephen J. Schuster, Max W. Richardson, Nils Wellhausen, Sonia Guedan
Publikováno v:
Cell
Summary Chimeric antigen receptor (CAR) T cell therapy has achieved remarkable success in hematological malignancies but remains ineffective in solid tumors, due in part to CAR T cell exhaustion in the solid tumor microenvironment. To study dysfuncti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db4dca3ac6b77cf3d1f795ac3d3904cd
https://pubmed.ncbi.nlm.nih.gov/34890549
https://pubmed.ncbi.nlm.nih.gov/34890549
Autor:
James L. Riley, Megan Estorninho, Lauren E. Nickolay, Timothy Tree, Caroline M. Hull, Max W. Richardson, John Maher, Mark Peakman
Publikováno v:
Hull, C M, Nickolay, L E, Estorninho, M, Richardson, M W, Riley, J L, Peakman, M, Maher, J & Tree, T I M 2017, ' Generation of human islet-specific regulatory T cells by TCR gene transfer ', Journal of Autoimmunity, vol. 79, pp. 63-73 . https://doi.org/10.1016/j.jaut.2017.01.001
Based on the success in animal models of type 1 diabetes (T1D), clinical trials of adoptive regulatory T cell (Treg) therapy are underway using ex vivo expanded polyclonal Tregs. However, pre-clinical data also demonstrate that islet-specific Tregs a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccddd16dbf295ae60e738df810dacf9a
https://doi.org/10.1016/j.jaut.2017.01.001
https://doi.org/10.1016/j.jaut.2017.01.001
Autor:
James L. Riley, Ronald G. Collman, Joshua Glover, Simon F. Lacey, Christoph T. Ellebrecht, Keith A. Dufendach, Colby R. Maldini, Yanjie Yi, Irina Kulikovskaya, Farida Shaheen, Michael C. Holmes, Anthony Secreto, Jianbin Wang, Aimee S. Payne, Rachel S. Leibman, Sarah R. Akkina, Max W. Richardson
Publikováno v:
PLoS Pathogens, Vol 13, Iss 10, p e1006613 (2017)
PLoS Pathogens
PLoS Pathogens
HIV is adept at avoiding naturally generated T cell responses; therefore, there is a need to develop HIV-specific T cells with greater potency for use in HIV cure strategies. Starting with a CD4-based chimeric antigen receptor (CAR) that was previous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c38ff7742cb4d715179ba71d3d3f0233
https://doaj.org/article/942f579e40144a97893d9fb154526278
https://doaj.org/article/942f579e40144a97893d9fb154526278
Autor:
Jianbin Wang, Josephine Romano, Beth S. Haggarty, Michael C. Holmes, James A. Hoxie, James L. Riley, Kevin Hua, Kritika E. Kumar, Andrea P. O. Jordon, George J. Leslie, Max W. Richardson, Philip D. Gregory, Anthony Secreto, Carl H. June, Jennifer Duong, Joshua J. DeClercq, Michael J. Root
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 12, Iss 11, p e1005983 (2016)
PLoS Pathogens, Vol 12, Iss 11, p e1005983 (2016)
HIV-1 entry can be inhibited by soluble peptides from the gp41 heptad repeat-2 (HR2) domain that interfere with formation of the 6-helix bundle during fusion. Inhibition has also been seen when these peptides are conjugated to anchoring molecules and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::347b289557740991009159ff95cf3e72
http://europepmc.org/articles/PMC5113989
http://europepmc.org/articles/PMC5113989
Autor:
David L. Bajor, Katelyn T. Byrne, Max W. Richardson, Timothy Chao, Jeffrey H. Lin, James L. Riley, Robert H. Vonderheide, Rebecca A. Evans, Ben Z. Stanger, Andrew J. Rech, Rafael Winograd, Mark S. Diamond, Nune Markosyan
Publikováno v:
JCI Insight. 1
In carcinogen-driven cancers, a high mutational burden results in neoepitopes that can be recognized immunologically. Such carcinogen-induced tumors may evade this immune response through “immunoediting,” whereby tumors adapt to immune pressure a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5afb6dc30e4a90bd16c7c1ced080717
https://doi.org/10.1172/jci.insight.88328
https://doi.org/10.1172/jci.insight.88328
Publikováno v:
The Journal of Immunology. 189:3815-3821
CCR5, a cell surface molecule critical for the transmission and spread of HIV-1, is dynamically regulated during T cell activation and differentiation. The molecular mechanism linking T cell activation to modulation of CCR5 expression remains undefin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2b1ad98332a05888ca0b8d601a107d0
https://doi.org/10.4049/jimmunol.1201431
https://doi.org/10.4049/jimmunol.1201431