Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Max Sarvestani"'
Autor:
Guisheng Li, Zhulin Tan, Yibo Xu, Kanwar P. S. Sidhu, Bo Qu, Melissa A. Herbage, Magnus C. Eriksson, Xingzhong Zeng, Carl A. Busacca, Jean-Nicolas Desrosiers, Thomas Hampel, Oliver Niemeier, Carsten Reichel, Mai Thi Quynh Dang, Marvin Schoerer, Dirk Kemmer, Melanie Eick, Holger Werle, Soojin Kim, Zhibin Li, Shankar Venkatraman, Lanqi Jia, David A. Claremon, Klaus Fuchs, Niklas Heine, Denis Byrne, Bikshandarkoil Narayanan, Max Sarvestani, Joe Johnson, Ajith Premasiri, Larry J. Nummy, Jon C. Lorenz, Nizar Haddad, Nina C. Gonnella, Scott Pennino, Mariusz Krawiec, Chris H. Senanayake, Frederic Buono, Heewon Lee, Azad Hossain, Jinhua J. Song, Jonathan T. Reeves
Publikováno v:
Organic Process Research & Development. 26:3345-3372
Autor:
Heewon Lee, Nelu Grinberg, Nitinchandra D. Patel, Andrew Ye, Azad Hossain, Carl A. Busacca, Jon C. Lorenz, Chris H. Senanayake, Anjan Saha, Denis Byrne, Nizar Haddad, Suresh R. Kapadia, Xudong Wei, Nathan K. Yee, Philomen DeCroos, Bikshandarkoil A. Narayanan, Max Sarvestani, Scott Pennino
Publikováno v:
The Journal of Organic Chemistry. 85:8339-8351
An efficient general methodology for the synthesis of 4-quinolinyl ethers is demonstrated via a highly reactive SNAr reaction of 4-quinolinyl sulfones with a range of structurally diversified 1°, 2°, and 3° alcohols with a wide substrate scope and
Autor:
Nitinchandra D, Patel, Xudong, Wei, Denis, Byrne, Bikshandarkoil A, Narayanan, Scott, Pennino, Max, Sarvestani, Anjan, Saha, Nizar, Haddad, Suresh, Kapadia, Jon C, Lorenz, Philomen, DeCroos, Andrew, Ye, Heewon, Lee, Nelu, Grinberg, Azad, Hossain, Carl A, Busacca, Nathan K, Yee, Chris H, Senanayake
Publikováno v:
The Journal of organic chemistry. 85(13)
An efficient general methodology for the synthesis of 4-quinolinyl ethers is demonstrated via a highly reactive S
Autor:
Carl A. Busacca, Jose M. Medina, Ivan Volchkov, Max Sarvestani, Andrew V. Kelleghan, Neil K. Garg
Publikováno v:
Org Lett
Silyl triflate precursors to benzyne and related intermediates have emerged as valuable synthetic building blocks. However, data addressing the safety of employing these silyl triflate precursors are lacking. We report the calorimetric analysis of a
Autor:
Jon C. Lorenz, Laurence J. Nummy, Xudong Wei, Jason Brazzillo, Irungu K. Luvaga, Chris H. Senanayake, Zhulin Tan, Jinhua J. Song, Bikshandarkoil A. Narayanan, Kanwar Sidhu, Nathan K. Yee, Maurice A. Marsini, Frederic G. Buono, Jonathan T. Reeves, Heewon Lee, Yongda Zhang, Max Sarvestani, Bing-Shiou Yang, Ning Li, Frank Roschangar, J. C. Chung
Publikováno v:
Green Chemistry. 19:1454-1461
A convergent, robust, and concise synthesis of a developmental CCR1 antagonist is described using continuous flow technology. In the first approach, following an expeditious SNAr sequence for cyclopropane introduction, a safe, continuous flow Curtius
Autor:
Chris H. Senanayake, Daniel R. Fandrick, Keith R. Fandrick, Christine A. Hart, James T. Masters, Max Sarvestani, Ifeanyi S. Okafor, Nelu Grinberg, Heewon Lee, Sanjit Sanyal, Jennifer L. Stockdill, Michael A. Mercadante, Nina C. Gonnella
Publikováno v:
Organic Letters. 18:6192-6195
The copper-catalyzed asymmetric propargylation of cyclic aldimines is reported. The influence of the imine trimer to inhibit the reaction was identified, and equilibrium constants between the monomer and trimer were determined for general classes of
Autor:
Joshua D. Sieber, Shengli Ma, Jolaine Savoie, Xudong Wei, Max Sarvestani, Dmitry Kurouski, Jean-Nicolas Desrosiers, Hari P. R. Mangunuru, Bo Qu, Heewon Lee, Nizar Haddad, Nelu Grinberg, Lalith P. Samankumara, Keith R. Fandrick, Jinhua J. Song, Nathan K. Yee, Chris H. Senanayake
Publikováno v:
Organic Letters. 18:4920-4923
An Ir-catalyzed enantioselective hydrogenation of 2-alkyl-pyridines has been developed using ligand MeO-BoQPhos. High levels of enantioselectivities up to 93:7 er were obtained. The resulting enantioenriched piperidines can be readily converted into
Autor:
Jon C. Lorenz, Carl A. Busacca, Dominique Hebrault, Nizar Haddad, Chris H. Senanayake, XuWu Feng, Rich Varsolona, Simon Rea, Leen Schellekens, Heewon Lee, Max Sarvestani, Suresh R. Kapadia, Bo Qu
Publikováno v:
Organic Process Research & Development. 19:132-138
A concise scalable synthesis of a chiral dipeptide acid, key substructure of the HCV protease inhibitor faldaprevir, has been developed. A green process with an E-factor of 9.2 was achieved utilizing process analytical technology (PAT) to allow effec
Autor:
Bo Qu, Daniel R. Fandrick, Jean-Nicolas Desrosiers, Xudong Wei, Nathan K. Yee, Joshua D. Sieber, Sonia Rodriguez, Xingzhong Zeng, Max Sarvestani, Chris H. Senanayake, Frank Roschangar, Jinhua J. Song
Publikováno v:
Asian Journal of Organic Chemistry. 4:1262-1264
A practical process was developed for the synthesis of 2-difluoromethylpyridines via a Cu-mediated Reductive Coupling-Hydrolysis-Decarboxylation sequence. The process employed 2-bromopyridines with a variety of functional groups on the pyridine as su
Autor:
Bo Qu, Jason A. Mulder, Max Sarvestani, Rogelio P. Frutos, Nizar Haddad, Jinhua J. Song, Tampone Thomas G, Magnus C. Eriksson, Nitinchandra D. Patel, Sherry Shen, Xiufeng Sun, Joe Gao, Chris H. Senanayake
Publikováno v:
Organic Process Research & Development. 17:940-945
Reported herein is a safe and economical synthesis of methyl 6-chloro-5-(trifluoromethyl)nicotinate, an intermediate in the synthesis of novel anti-infective agents. The key to this process is the trifluoromethylation of an aryl iodide using an inexp