Zobrazeno 1 - 10
of 552
pro vyhledávání: '"Max S. Wicha"'
Autor:
Deeksha Sharma, Cody G. Hager, Li Shang, Lam Tran, Yongyou Zhu, Aihui Ma, Brian Magnuson, Matthew W. Lesko, Max S. Wicha, Monika L. Burness
Publikováno v:
Breast Cancer Research, Vol 25, Iss 1, Pp 1-17 (2023)
Abstract Background Breast cancer stem cells (BCSCs) are resistant to standard therapies, facilitate tumor dissemination, and contribute to relapse and progression. Super-enhancers are regulators of stemness, and BET proteins, which are critical for
Externí odkaz:
https://doaj.org/article/6f7b31ca863f456889a102d656ed7db6
Autor:
Vincent L. Chen, Qianhui Huang, Ramdane Harouaka, Yuheng Du, Anna S. Lok, Neehar D. Parikh, Lana X. Garmire, Max S. Wicha
Publikováno v:
Hepatology Communications, Vol 6, Iss 6, Pp 1482-1491 (2022)
Hepatocellular carcinoma (HCC) is a leading cause of cancer death worldwide. Identification and sequencing of circulating tumor (CT) cells and clusters may allow for noninvasive molecular characterization of HCC, which is an unmet need, as many patie
Externí odkaz:
https://doaj.org/article/ec1169c729cb4aed9defa3d7cc42afb6
Autor:
Sm N. Udden, Qian Wang, Sunil Kumar, Venkat S. Malladi, Shwu-Yuan Wu, Shuguang Wei, Bruce A. Posner, Sophie Geboers, Noelle S. Williams, Yulun Liu, Jayesh K. Sharma, Ram S. Mani, Srinivas Malladi, Karla Parra, Mia Hofstad, Ganesh V. Raj, Jose M. Larios, Reshma Jagsi, Max S. Wicha, Ben Ho Park, Gaorav P. Gupta, Arul M. Chinnaiyan, Cheng-Ming Chiang, Prasanna G. Alluri
Publikováno v:
JCI Insight, Vol 7, Iss 17 (2022)
Acquired mutations in the ligand-binding domain (LBD) of the gene encoding estrogen receptor α (ESR1) are common mechanisms of endocrine therapy resistance in patients with metastatic ER+ breast cancer. The ESR1 Y537S mutation, in particular, is ass
Externí odkaz:
https://doaj.org/article/d418606d92724bfe9c78d27a68b05327
Autor:
Grace G. Bushnell, Abhijeet P. Deshmukh, Petra den Hollander, Ming Luo, Rama Soundararajan, Dongya Jia, Herbert Levine, Sendurai A. Mani, Max S. Wicha
Publikováno v:
npj Breast Cancer, Vol 7, Iss 1, Pp 1-12 (2021)
Abstract Breast cancer is the most commonly diagnosed cancer in the USA. Although advances in treatment over the past several decades have significantly improved the outlook for this disease, most women who are diagnosed with estrogen receptor positi
Externí odkaz:
https://doaj.org/article/69f901f9c94041478c1dbc00eb262202
Autor:
Shaocheng Wu, Hongjiu Zhang, Shamileh Fouladdel, Hongyang Li, Evan Keller, Max S. Wicha, Gilbert S. Omenn, Ebrahim Azizi, Yuanfang Guan
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 676-685 (2020)
Tumor heterogeneity is generated through a combination of genetic and epigenetic mechanisms, the latter of which plays an important role in the generation of stem like cells responsible for tumor formation and metastasis. Although the development of
Externí odkaz:
https://doaj.org/article/fed0a4f05add42129136ccae1c5de612
Autor:
Yu-Heng Cheng, Yu-Chih Chen, Eric Lin, Riley Brien, Seungwon Jung, Yu-Ting Chen, Woncheol Lee, Zhijian Hao, Saswat Sahoo, Hyun Min Kang, Jason Cong, Monika Burness, Sunitha Nagrath, Max S. Wicha, Euisik Yoon
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Transcriptome analysis of circulating tumor cells (CTCs) provides insights into monitoring target therapeutics and underlying tumor metastasis. Here the authors present Hydro-Seq, a contamination-free high-throughput hydrodynamic scRNA-seq barcoding
Externí odkaz:
https://doaj.org/article/8f568b6e3e6b49b99506d87fda212237
Autor:
Raziye Piranlioglu, EunMi Lee, Maria Ouzounova, Roni J. Bollag, Alicia H. Vinyard, Ali S. Arbab, Daniela Marasco, Mustafa Guzel, John K. Cowell, Muthushamy Thangaraju, Ahmed Chadli, Khaled A. Hassan, Max S. Wicha, Esteban Celis, Hasan Korkaya
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Dissemination of tumor cells from the primary site is an early event. Here, the authors show that the early disseminated tumor cells are actively cleared by the host cytotoxic T lymphocytes induced by the primary tumor and that infiltration of granul
Externí odkaz:
https://doaj.org/article/ab8309125be1466c9f20adaacc94d582
Autor:
Tasha Thong, Yutong Wang, Michael D. Brooks, Christopher T. Lee, Clayton Scott, Laura Balzano, Max S. Wicha, Justin A. Colacino
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Similarities between stem cells and cancer cells have implicated mammary stem cells in breast carcinogenesis. Recent evidence suggests that normal breast stem cells exist in multiple phenotypic states: epithelial, mesenchymal, and hybrid epithelial/m
Externí odkaz:
https://doaj.org/article/3d368196c177406e9f920e93f3e5ca04
Autor:
Justin A. Colacino, Ebrahim Azizi, Michael D. Brooks, Ramdane Harouaka, Shamileh Fouladdel, Sean P. McDermott, Michael Lee, David Hill, Julie Madden, Julie Boerner, Michele L. Cote, Maureen A. Sartor, Laura S. Rozek, Max S. Wicha
Publikováno v:
Stem Cell Reports, Vol 10, Iss 5, Pp 1596-1609 (2018)
Summary: During development, the mammary gland undergoes extensive remodeling driven by stem cells. Breast cancers are also hierarchically organized and driven by cancer stem cells characterized by CD44+CD24low/− or aldehyde dehydrogenase (ALDH) ex
Externí odkaz:
https://doaj.org/article/b9efa7a99ce34971b517c5e10fc53566
Publikováno v:
Cells, Vol 10, Iss 9, p 2415 (2021)
Cancer has long been viewed as a disease of normal development gone awry. Cancer stem-like cells (CSCs), also termed as tumor-initiating cells (TICs), are increasingly recognized as a critical tumor cell population that drives not only tumorigenesis
Externí odkaz:
https://doaj.org/article/732aeb60d3254847abdb1ccdbad126ba