Zobrazeno 1 - 10
of 187
pro vyhledávání: '"Max S. Cynader"'
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0142296 (2015)
TDP-43 (TAR DNA binding protein 43) is a heterogeneous nuclear ribonucleoprotein (hnRNP) that has been found to play an important role in neurodegenerative diseases. TDP-43's involvement in nuclear factor-kappaB pathways has been reported in both neu
Externí odkaz:
https://doaj.org/article/218c8a7d3cb44cd7bf1bb203a4de808d
Autor:
Noo Li Jeon, Max S. Cynader, Austen J. Milnerwood, Yu Tian Wang, Ainsley Coquinco, Wendy Wen, Luba Kojic
Publikováno v:
Molecular and Cellular Neuroscience. 60:43-52
Synaptic competition is widely believed to be central to the formation and function of neuronal networks, yet the underlying mechanisms are poorly described. To investigate synaptic competition in vitro, we have developed a novel two input pathway co
Progranulin promotes activation of microglia/macrophage after pilocarpine-induced status epilepticus
Autor:
Max S. Cynader, Zhifang Dong, Qing Chang, Shanshan Zhu, Si Zhang, Chengyong Liao, William Jia, Yu Tian Wang, Terri L. Petkau, Blair R. Leavitt, Brian A. MacVicar, Wendy Wen, Chao Tai
Publikováno v:
Brain Research. 1530:54-65
Progranulin (PGRN) haploinsufficiency accounts for up to 10% of frontotemporal lobe dementia. PGRN has also been implicated in neuroinflammation in acute and chronic neurological disorders. Here we report that both protein and mRNA levels of cortical
Autor:
Elodie Portales-Casamar, Louis-Philippe Lemieux-Perreault, Paul Pavlidis, Albert E. Chudley, Amina Barhdadi, Sarah M Mah, Julia L. MacIsaac, Meaghan J. Jones, Marie-Pierre Dubé, James N. Reynolds, Max S. Cynader, Sylvie Provost, Rachel D. Edgar, Alexandre A. Lussier, Michael S. Kobor
Publikováno v:
Epigenetics & Chromatin
Background: Prenatal alcohol exposure is the leading preventable cause of behavioral and cognitive deficits, which may affect between 2 and 5 % of children in North America. While the underlying mechanisms of alcohol’s effects on development remain
Autor:
Ainsley Coquinco, Max S. Cynader, Marja D. Sepers, Lynn A. Raymond, Liang Wang, Clare M. Gladding, Lily Y. J. Zhang, Jing Fan, Alexandra M. Kaufman, Austen J. Milnerwood, Hwan Lee, Joy Yi Qiao, Yu Tian Wang
Publikováno v:
Neurobiology of Disease, Vol 48, Iss 1, Pp 40-51 (2012)
We recently reported evidence for disturbed synaptic versus extrasynaptic NMDAR transmission in the early pathogenesis of Huntington's disease (HD), a late-onset neurodegenerative disorder caused by CAG repeat expansion in the gene encoding huntingti
Autor:
Ainsley Coquinco, Marja D. Sepers, Lynn A. Raymond, Alexandra M. Kaufman, Austen J. Milnerwood, Kevin She, Liang Wang, Hwan Lee, Max S. Cynader, Ann Marie Craig
Publikováno v:
The Journal of Neuroscience. 32:3992-4003
The NMDAR plays a unique and vital role in subcellular signaling. Calcium influx initiates signaling cascades important for both synaptic plasticity and survival; however, overactivation of the receptor leads to toxicity and cell death. This dichotom
Publikováno v:
European Journal of Neuroscience. 30:35-46
The AMPA receptor (AMPAR) subunits GluR1 and GluR2 show different properties in central neurons and affect AMPAR trafficking via distinct mechanisms. This subunit-specificity is partly achieved by recruiting unique protein modifications on different
Publikováno v:
Brain Research. 1250:49-62
We report the first demonstration that Krupple-like factor 4 (KLF4) mRNA is dramatically and rapidly upregulated by NMDA application in primary cortical neuron cultures. We also report that NMDA induced significant and transient upregulation of KLF4
Autor:
Max S. Cynader, Ainsley Coquinco
Publikováno v:
Neuromethods ISBN: 9781493925094
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8eb373767ec035845ac2f9bdb45c470
https://doi.org/10.1007/978-1-4939-2510-0_8
https://doi.org/10.1007/978-1-4939-2510-0_8
Publikováno v:
Free Radical Biology and Medicine. 40:960-967
Oxidative stress plays an important role in the pathogenesis of multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE). Bilirubin is regarded today as a potent antioxidant. Recent studies show that the potent antioxi