Zobrazeno 1 - 10
of 554
pro vyhledávání: '"Max S Wicha"'
Autor:
Michail Yekelchyk, Esha Madan, Jochen Wilhelm, Kirsty R Short, António M Palma, Linbu Liao, Denise Camacho, Everlyne Nkadori, Michael T Winters, Emily S Rice, Inês Rolim, Raquel Cruz‐Duarte, Christopher J Pelham, Masaki Nagane, Kartik Gupta, Sahil Chaudhary, Thomas Braun, Raghavendra Pillappa, Mark S Parker, Thomas Menter, Matthias Matter, Jasmin Dionne Haslbauer, Markus Tolnay, Kornelia D Galior, Kristina A Matkwoskyj, Stephanie M McGregor, Laura K Muller, Emad A Rakha, Antonio Lopez‐Beltran, Ronny Drapkin, Maximilian Ackermann, Paul B Fisher, Steven R Grossman, Andrew K Godwin, Arutha Kulasinghe, Ivan Martinez, Clay B Marsh, Benjamin Tang, Max S Wicha, Kyoung Jae Won, Alexandar Tzankov, Eduardo Moreno, Rajan Gogna
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 11, Pp n/a-n/a (2021)
Abstract Risk stratification of COVID‐19 patients is essential for pandemic management. Changes in the cell fitness marker, hFwe‐Lose, can precede the host immune response to infection, potentially making such a biomarker an earlier triage tool.
Externí odkaz:
https://doaj.org/article/f8eb078fb27a469bb4350f69d131fd6a
Autor:
Hui Yao, Mou Gao, Jianhua Ma, Maoying Zhang, Shaowu Li, Bingshan Wu, Xiaohu Nie, Jiao Jiao, Hao Zhao, Shanshan Wang, Yuanyuan Yang, Yesen Zhang, Yilin Sun, Max S Wicha, Alfred E Chang, Shaorong Gao, Qiao Li, Ruxiang Xu
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0137211 (2015)
Induced neural stem cells (iNSCs) can be directly transdifferentiated from somatic cells. One potential clinical application of the iNSCs is for nerve regeneration. However, it is unknown whether iNSCs function in disease models. We produced transdif
Externí odkaz:
https://doaj.org/article/ba740262df264627be6746d0c0a74bfd
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0135797 (2015)
Cancer stem cells (CSCs) possess capacity to both self-renew and generate all cells within a tumor, and are thought to drive tumor recurrence. Targeting the stem cell niche to eradicate CSCs represents an important area of therapeutic development. Th
Externí odkaz:
https://doaj.org/article/5f96ede182a647c3a52111466b666cc6
Publikováno v:
Clinical and Translational Medicine, Vol 3, Iss 1, Pp n/a-n/a (2014)
Abstract In the past decade, the traditional view of cancers as a homogeneous collection of malignant cells is being replaced by a model of ever increasing complexity suggesting that cancers are complex tissues composed of multiple cell types. This c
Externí odkaz:
https://doaj.org/article/ae95c30a15874529956aab5e0143333c
Autor:
Li Lin, Brian Hutzen, Hsiu-Fang Lee, Zhengang Peng, Wenlong Wang, Chongqiang Zhao, Huey-Jen Lin, Duxin Sun, Pui-Kai Li, Chenglong Li, Hasan Korkaya, Max S Wicha, Jiayuh Lin
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e82821 (2013)
STAT3 activation is frequently detected in breast cancer and this pathway has emerged as an attractive molecular target for cancer treatment. Recent experimental evidence suggests ALDH-positive (ALDH(+)), or cell surface molecule CD44-positive (CD44(
Externí odkaz:
https://doaj.org/article/284652a4bed94c1faa0710b55d99ed0c
Autor:
Deeksha Sharma, Cody G. Hager, Li Shang, Lam Tran, Yongyou Zhu, Aihui Ma, Brian Magnuson, Matthew W. Lesko, Max S. Wicha, Monika L. Burness
Publikováno v:
Breast Cancer Research, Vol 25, Iss 1, Pp 1-17 (2023)
Abstract Background Breast cancer stem cells (BCSCs) are resistant to standard therapies, facilitate tumor dissemination, and contribute to relapse and progression. Super-enhancers are regulators of stemness, and BET proteins, which are critical for
Externí odkaz:
https://doaj.org/article/6f7b31ca863f456889a102d656ed7db6
Autor:
Suling Liu, Shivani H Patel, Christophe Ginestier, Ingrid Ibarra, Rachel Martin-Trevino, Shoumin Bai, Sean P McDermott, Li Shang, Jia Ke, Sing J Ou, Amber Heath, Kevin J Zhang, Hasan Korkaya, Shawn G Clouthier, Emmanuelle Charafe-Jauffret, Daniel Birnbaum, Gregory J Hannon, Max S Wicha
Publikováno v:
PLoS Genetics, Vol 8, Iss 6, p e1002751 (2012)
MicroRNAs (miRNAs) play important roles in normal cellular differentiation and oncogenesis. microRNA93 (mir-93), a member of the mir106b-25 cluster, located in intron 13 of the MCM7 gene, although frequently overexpressed in human malignancies may al
Externí odkaz:
https://doaj.org/article/e2e13e3a52c445e382b014943bf1ac2e
Autor:
Hasan Korkaya, Amanda Paulson, Emmanuelle Charafe-Jauffret, Christophe Ginestier, Marty Brown, Julie Dutcher, Shawn G Clouthier, Max S Wicha
Publikováno v:
PLoS Biology, Vol 7, Iss 6, p e1000121 (2009)
Recent evidence suggests that many malignancies, including breast cancer, are driven by a cellular subcomponent that displays stem cell-like properties. The protein phosphatase and tensin homolog (PTEN) is inactivated in a wide range of human cancers
Externí odkaz:
https://doaj.org/article/96528813e9484ad485e4ade316537d43
Autor:
Vincent L. Chen, Qianhui Huang, Ramdane Harouaka, Yuheng Du, Anna S. Lok, Neehar D. Parikh, Lana X. Garmire, Max S. Wicha
Publikováno v:
Hepatology Communications, Vol 6, Iss 6, Pp 1482-1491 (2022)
Hepatocellular carcinoma (HCC) is a leading cause of cancer death worldwide. Identification and sequencing of circulating tumor (CT) cells and clusters may allow for noninvasive molecular characterization of HCC, which is an unmet need, as many patie
Externí odkaz:
https://doaj.org/article/ec1169c729cb4aed9defa3d7cc42afb6
Autor:
Sm N. Udden, Qian Wang, Sunil Kumar, Venkat S. Malladi, Shwu-Yuan Wu, Shuguang Wei, Bruce A. Posner, Sophie Geboers, Noelle S. Williams, Yulun Liu, Jayesh K. Sharma, Ram S. Mani, Srinivas Malladi, Karla Parra, Mia Hofstad, Ganesh V. Raj, Jose M. Larios, Reshma Jagsi, Max S. Wicha, Ben Ho Park, Gaorav P. Gupta, Arul M. Chinnaiyan, Cheng-Ming Chiang, Prasanna G. Alluri
Publikováno v:
JCI Insight, Vol 7, Iss 17 (2022)
Acquired mutations in the ligand-binding domain (LBD) of the gene encoding estrogen receptor α (ESR1) are common mechanisms of endocrine therapy resistance in patients with metastatic ER+ breast cancer. The ESR1 Y537S mutation, in particular, is ass
Externí odkaz:
https://doaj.org/article/d418606d92724bfe9c78d27a68b05327