Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Max Russo"'
Autor:
Lishan Fang, Dane Ford-Roshon, Max Russo, Casey O’Brien, Xiaozhe Xiong, Carino Gurjao, Maximilien Grandclaudon, Srivatsan Raghavan, Steven M. Corsello, Steven A. Carr, Namrata D. Udeshi, James Berstler, Ewa Sicinska, Kimmie Ng, Marios Giannakis
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
The RNF43 G659fs mutation occurs frequently in colorectal cancer, but its function remains poorly understood. In this study, the authors show that RNF43 G659fs is an oncogenic colorectal cancer mutation and sensitizes tumor cells to PI3K/mTOR inhibit
Externí odkaz:
https://doaj.org/article/f27b6baf1c414b9d98b4607879f425b8
Autor:
Marco Grodzki, Andrew P. Bluhm, Moritz Schaefer, Abderrahmane Tagmount, Max Russo, Amin Sobh, Roya Rafiee, Chris D. Vulpe, Stephanie M. Karst, Michael H. Norris
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-18 (2022)
Abstract Background The COVID-19 pandemic has resulted in 275 million infections and 5.4 million deaths as of December 2021. While effective vaccines are being administered globally, there is still a great need for antiviral therapies as antigenicall
Externí odkaz:
https://doaj.org/article/0389603ba2a943b3a03f0bb2d378231d
Autor:
Bin Liu, Ariana M Figueroa, Abderrahmane Tagmount, Sara T. Humes, Alex Loguinov, Chris D. Vulpe, Ping Zhang, Tara Sabo-Attwood, Max Russo, John A. Lednicky
Publikováno v:
Toxicological Sciences. 182:260-274
Organochlorine pesticides (OCPs) are persistent pollutants linked to diverse adverse health outcomes. Environmental exposure to OCPs has been suggested to negatively impact the immune system but their effects on cellular antiviral responses remain un
Autor:
Marios Giannakis, Lishan Fang, Dane Ford-Roshon, Max Russo, Casey O'Brien, Xiaozhe Xiong, Carino Gurjao, Maximilien Grandclaudon, Srivatsan Raghavan, Steven M. Corsello, Steven A. Carr, Namrata Udeshi, James Berstler, Ewa Sicinska, Kimmie Ng
Publikováno v:
Cancer Research. 82:PR009-PR009
Introduction: The RNF43 p.G659fs mutation occurs with a frequency of approximately 8% in colorectal cancer (CRC) and is enriched among microsatellite-instability high tumors. However, despite RNF43 being implicated as a Wnt-signaling tumor suppressor
Autor:
Lishan Fang, Dane Ford-Roshon, Max Russo, Casey O’Brien, Xiaozhe Xiong, Carino Gurjao, Maximilien Grandclaudon, Srivatsan Raghavan, Steven M. Corsello, Steven A. Carr, Namrata D. Udeshi, James Berstler, Ewa Sicinska, Kimmie Ng, Marios Giannakis
Publikováno v:
Nature communications. 13(1)
The RNF43_p.G659fs mutation occurs frequently in colorectal cancer, but its function remains poorly understood and there are no specific therapies directed against this alteration. In this study, we find that RNF43_p.G659fs promotes cell growth indep
Autor:
Michael H. Norris, Roya Rafiee, Stephanie M. Karst, Chris D. Vulpe, Abderrahmane Tagmount, Amin Sobh, Schafer M, Andrew P. Bluhm, Max Russo, Grodzki M
The COVID-19 pandemic has resulted in 153 million infections and 3.2 million deaths as of May 2021. While effective vaccines are being administered globally, there is still a great need for antiviral therapies as potentially antigenically distinct SA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98d25c44c86f155e2587f567c59cb8d4
https://doi.org/10.1101/2021.06.04.447090
https://doi.org/10.1101/2021.06.04.447090
Publikováno v:
Current protocolsLITERATURE CITED. 1(5)
The use of genome editing tools is expanding our understanding of various human diseases by providing insight into gene-disease interactions. Despite the recognized role of toxicants in the development of human health issues and conditions, there is
Autor:
Ping Zhang, Abderrahmane Tagmount, Chris D. Vulpe, Amin Sobh, Bin Liu, Max Russo, Alex Loguinov
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 176(2)
Organochlorine pesticides, once widely used, are extremely persistent and bio-accumulative in the environment. Epidemiological studies have implicated that environmental exposure to organochlorine pesticides including dieldrin is a risk factor for th
Autor:
Max Russo, Namrata D. Udeshi, Kimmie Ng, Casey O’Brien, Marios Giannakis, Steven M. Corsello, Maximilien Grandclaudon, Carino Gurjao, Srivatsan Raghavan, Dane Ford-Roshon, Lishan Fang, Ewa Sicinska, James Berstler
Publikováno v:
Cancer Research. 81:960-960
Introduction: RNF43 is a transmembrane E3 ubiquitin ligase and WNT signaling suppressor that is commonly mutated in colorectal cancer (CRC). A C-terminal RNF43 hotspot mutation, RNF43_G659fs, occurs in approximately 36% (55/151) of microsatellite-ins
Publikováno v:
The FASEB Journal. 33